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By John E. Udd

I N Part I of this paper, Professor Morrison suggested that our technique of causing cracks to develop around openings in a sheet of photoe1ashc plastic is, in effect, a laboratory-scale rockburst. Our investigations have indicated that the location and direction of these cracks are predictable, and that their growth can be controlled. On several occasions, we have been able to cause these cracks to propagate sufficiently slowly to be followed, with the naked eye. In practice, the rate of growth, gradual or sudden, would depend upon rock properties. This part of the paper presents an analysis of the stresses surrounding the openings before and after failure and also this author's views on the causes and after-effects of cracking. An attempt is made to correlate the stress patterns with those deter-mined from pure mathematics. Considering that the openings, except for the central enlargement, are long apertures with somewhat rounded corners, they might be compared with elongated ellipses having axes ratios of about 20:1 or with

Jan 1, 1963

By W. H. Zieman

NORMAN WEISS, Milling Engineer, American Smelting• and Refining Company: The subject of the Forum on Rod and Ball Mill Liners is very fascinating, and there is no end of discussion when operators get together on grinding. However, the hypotheses and suppositions easily outrun the facts, especially when we •consider the inaccuracy of many reported observations. Still surprisingly small is the number of concentrators even reasonably well equipped to measure power consumption of each grinding mill, together with running time, so that data on this tangible factor, at least, can be obtained with precision. While the more elaborate devices of this nature, producing for each 24-hour period the total power consumption, average kilowatt hours per hour, short-term demand chart, instantaneous demand, and print-out, may cost in the neighbourhood of $2,500 per mill and may be difficult to justify, the combination of an ammeter, watthour meter, and running-time meter will cost only a few hundred dollars, so there appears to be little reason not to in-stall them in view of their numerous advantages.

Jan 1, 1959

By Arthur D. FitzGerald

EDC established an Environmental Review Framework in 1999. Throughout the early fall of 2001, the Corporation held public consultations across Canada to strengthen that framework, leading to a public release on November 15, 2001 of a report summarising the results of these consultations. Following this, the Corporation implemented strengthened environmental review requirements in the form of its Environmental Review Directive, in compliance with legislated amendments to Canada?s Export Development Act that went into effect on December 21, 2001. Over the past few years, there has been a global trend towards an increase in the social and environmental requirements of multilateral/bilateral financial institutions and export credit agencies. More recently, this activity has focussed on capturing institutions that have not yet adopted similar requirements and, more specifically, on developing a convergence of the requirements from institution to institution. This paper describes EDC?s new ERD and some of the initiatives that have taken place or are in process that are moving international financial institutions toward converging their environmental and social requirements for projects in the private sector.

May 1, 2002

By S. Avalos, J. M. Ortiz, W. Kracht

Semi-autogenous grinding mills are intensive energy consumers. Current models base their energy consumption inference on operational variables and feeding ore characterization. While they provide adequate design guidelines, they are not suitable for real-time energy forecasting dealing with gaps in operational dataset and up/downstream process bottlenecks. This work explores the capability of Gated Recurrent Units to learn the semi-autogenous grinding mill consumption behaviour. Gated Recurrent Units are trained to forecast different time-support consumptions under a time-series operational dataset. The results show high performance on small supports (30 minutes) to capture local variability and long-trends while larger time supports (8 hours) can only capture time-trends but not local variability. The proposed technique seems promising for further research and implementation on real mine cases since the input variables are low-cost and easy to obtain. INTRODUCTION Current changes in the Chilean energy matrix (Román-Collado, Ordoñez, & Mundaca, 2018), from fossil fuels to renewable energies, have impacted different industries and particularly the mining sector. Solar energy incorporation into greenfield/brownfield projects will help reducing costs and will lead to rethink foundational paradigms (production and processing strategies) (Pamparana et al., 2017). Also, integration of new space-time predicting tools together with automated real-time updating models are some of the main challenges in the geometallurgical framework (Ortiz et al., 2015; van den Boogaart & Tolosana-Delgado, 2018). Those contexts encourage and demand the development of tools capable of predicting the energy consumed by mining systems, being comminution the greatest energy consumer with an average close to 50% of the entire mine consumption (Cochilco, 2013). In comminution, the semi-autogenous grinding mill (SAG) represents the largest energy consumer (~10 nominal each SAG). Theoretical and empirical energy consumption models (Jnr & Morrell, 1995; Morrell, 2004; Silva & Casali, 2015) base their inferences mainly on feed/product size distributions, SAG sizing, bearing pressure, feed hardness, water addition and grinding charge level, and commonly assume steady-state and work isolated from up and downstream processes. While those techniques provide adequate design guidelines, they are not suitable to predict hourly, daily or even weekly energy consumptions on interconnected comminution circuits where upstream/downstream bottlenecks lead SAGs to operate below designed regimes. Forecasting energy consumption is required by short-term energy management, medium and long-term planning energy consumption, designing the nominal capacity of renewable energy sources, among other. Also, when models are input-sensitive and some of those input measurements are expensive and/or time consuming, model robustness suffers when real-time predictions are required.

Jan 1, 2019

By D. K. Storer, W. Lee, S. Tkach

"A microcomputer-controlled multi-probe K-40 monitoring system was developed internally for the Phase II mill at the Lanigan potash mine. The K-40 probes were mounted in a variety of positions in several process streams, ranging from dry ore on a conveyor belt to brines and slurries. A description will be presented of the objectives, the equipment and the difficulties encountered in correlating results.IntroductionThe successful control and optimization of most metallurgical processes involves monitoring not only physical parameters such as flow rate and temperature, but also the chemical compositions of critical streams. Composition has proven difficult to measure on -line in industrial scale processes. However, in potash processing there is a convenient chemical parameter that has long been utilized to measure in situ the concentration of potassium chloride (KCl). Potassium has a long-lived isotope which is slightly radioactive. K40 decays by beta elimination to Ca40, ultimately radiating a characteristic gamma-ray photon. This gamma emission when detected by scintillation counter can be used to estimate the concentration of potassium in a process stream."

Jan 1, 1990

By G. J. Hutchins

Precision surface mining is gaining traction in the iron ore, copper, iodine, limestone, bauxite, coal and gypsum markets. In this paper, we first address the possible improvements of a surface miner control using GPS techniques. An application in an iron ore mine in Western Australia is presented. The second item addressed is improvements of a new drum driving technique for a 100 ton surface miner. This technique involves installing a slow speed hydrostatic motor directly on the cutting drum rather than driving the drum through chain and sprockets. Details of the performance of this direct-drive versus the chain-drive are detailed. In addition to the 100 ton machine, we also present a 200 ton surface miner. This larger machine has 1600 hp (894.8 kg), and has been successfully introduced into a large iron ore mine in Western Australia. Performance of the 200 ton surface mining machine in various rock hardnesses is detailed. Some comments on the cost effectiveness of using a built-in loader versus loading with wheel loaders are included.

Aug 1, 2013

By N. W. Martison, J. E. Hawley

"The Moulton Hill deposit is in the Eastern Townships of Quebec, 3 miles northeast of Sherbrooke. It is complex, both structurally and mineralogically, consisting of a narrow, irregular, mineralized zone that has been traced for a length of 600 feet, and in places to a depth of 1,000 feet, containing copper, lead, and zinc sulphides with a low content of gold and silver. It lies in a series of highly schistose micaceous rocks, believed to be of Ordovician age, but the mineralization is probably post-Lower Devonian. New details of the structure of the ore have become available since it was first described (1) , and as these show some striking peculiarities a further discussion is here merited .As detailed elsewhere, the deposit was discovered in 1942 as a result of regional geological studies followed by the application of electrical geophysical methods.Actual production began in July, 1944, and ceased in June, 1945. During the period July, 1944 to June, 1945, 75,643 tons were milled§, yielding the following:"

Jan 1, 1954

By Li Qihou, Liu Zhihong, Liu Zhiyong, Yao Wei

Black copper sludge, which mainly contains copper, arsenic and a little antimony, bismuth, selenium, tellurium, is an important recyclable secondary resource. In this paper, selective removal of arsenic from black copper sludge by alkaline oxidative pressure leaching was studied. The influences of alkali concentration, leaching time, leaching temperature, oxygen pressure, liquid-solid ratio and other variables on the leaching rate of arsenic, copper and tellurium were investigated. The results were as follows: when the leaching process was conducted at initial alkali concentration of 1mol/L, liquid-solid ratio of 10, stirring rate of 500r/min, leaching temperature of 140°C for 5 h and oxygen pressure of 2.5MPa, the leaching rates of arsenic and tellurium were 85.43% and 59.7% respectively, and copper, antimony, bismuth were not leached. Hence, arsenic has been removed effectively from black copper sludge, while the valuable metals such as copper, antimony and bismuth remained in the residue that can be further recovered easily. INTRODUCTION Black copper sludge is a byproduct in the purification process of copper electrolyte. Arsenic, antimony and bismuth are major harmful impurities in copper electrolytic refining system. The accumulation of these impurities will cause adverse effects, such as the increase of electrolyte resistance and power consumption and deterioration of cathode copper quality (Wang, Liu, & Zhang, 2001). Hence, electrolyte purification is an essential part of the electrolysis process (Liang, Chen, & Guo, 2009). Electrolyte purification methods include electrowinning (Davenport, King, Schlesinger, & Biswas, 2002), solvent extraction (Navarro, Simpson, & Alguacil, 1999), ion exchange (Arroyo et al., 2017), coprecipitation (Wang et al., 2003, 2018; Xiao et al., 2007; Xiao, Cao, Mao, Shen, & Ren, 2014), activated carbon adsorption (Navarro & Alguacil, 2002), electrodialysis (Cifuentes et al., 2015), redox process (Zhou, Peng, Zheng, Ma, & Cui, 2011; Peng, Zheng, Zhou, & Chen, 2012; Zheng, Peng, Ke, & Chen, 2013), among which the electrowinning method is simple in operation and effective in impurities removal, making it the main process for current electrolyte purification. Some copper ions can react with harmful impurities to form complex black copper sludge by controlling the operation conditions of electrowinning process. Based on the estimated data provide by Davenport et al. (2002), an annual output of 400,000 tons cathode copper could produce 432-2168 tons of black copper sludge by electrowinning method. Black copper sludge contains 30~50% copper, 15~30% arsenic and a small amount of rare elements such as selenium and tellurium. Thus, recovery of valuable metals can bring huge economic interests. Moreover, arsenic in these sludges could cause significant environmental pollution. Therefore, effective removal of arsenic from these sludges is urgent and significant.

Jan 1, 2019

By Steve Hubbard, Brad Marchant, Rolando Cuadra

"Triton Mining Corporation acquired the rights to Mina El Limon in Nicaragua in 1993 by international bid. The bid included the gold operations at Limon and an exploration concession of approximately 4000 km2. Triton assumed control of operations and exploration in May 1994.The Limon mine is located in west-central Nicaragua, approximately 100 kilometers northwest of Managua. The climate is tropical, characterized by a wet season from May through October, and a dry season November through April. Gold at Limon is associated with both banded quartz and silicified breccia veins in Tertiary volcanic rocks, belonging to the lower Coyol Group. Mining is from two open pits and one mechanized underground operation. A second underground mine is currently under development for production during 1997.This paper describes the expansion of the milling facility at El Limon from a nominal capacity of 400 tonnes/day, producing approximately 20,000 ounces of gold annually, to the existing 900 tonne per day mill operation. Engineering of the new mill facility was initiated in September 1994 and construction was completed a year later."

Jan 1, 1997

By Farzad Mohammadi, Patrick Littlejohn, David Sanguinetti

Arsenic levels in metal concentrates are increasing as mining companies turn to developing low grade and complex ores. When arsenic bearing minerals are smelted, arsenic deports as gases which must be neutralized by a scrubber system. The resulting scrubber effluent is high in dissolved arsenic and requires treatment before the wastewater can be discharged or re-used. Conventional arsenic removal relies on lime addition followed by calcium arsenate formation and precipitation as hydroxides. As an alternative, arsenic removal with sulphide precipitation is receiving more attention due to potential advantages of the technology. Process streams high in arsenic often contain concentrations of dissolved metals that may be selectively recovered during sulphidization, producing a product that can be reprocessed and reducing waste generation. This paper will review laboratory testing completed for arsenic removal through sulphide addition and precipitation of arsenic (III) sulphide in combination with metals recovery to offset arsenic removal costs.

Jan 1, 2014

By Rodney S. Read

This paper outlines a reasoned argument why no large-scale fracturing or faulting will be induced in the host rock by a deep geological repository (DGR) for nuclear fuel waste. Four DGR designs in three possible host rocks, including crystalline and sedimentary rock types, are considered. The reasoned argument draws from results of previously conducted thermal- mechanical analyses and new scoping calculations, along with evidence from experiments conducted in Canada and elsewhere. It is concluded that large-scale fracturing in the far-field is implausible given the expected in situ stress conditions in relation to rock strength. Near-field damage development and fracturing are expected in DGR scenarios in the different rock types, but these near-field effects are not expected to lead to large-scale fracturing that could compromise the integrity of the DGR and surrounding rock mass. Additional analysis and characterization activities are recommended to further validate the reasoned argument. Thermo-poroelastic loading of the rock mass is identified as one possible driving mechanism that should be studied further.

May 1, 2009

By Emilie Williams

The Mouska Mine uses primarily shrinkage mining to extract the narrow veins that contain its mineralization. Mining is currently occurring on levels 12 to 14, reaching depths of 800 m below surface. Although the mine is not considered ?deep?, no backfill is available to fill empty stopes and certain areas remain open for over 500 m in height. As only narrow sill pillars remain to separate the levels, a highstress environment is created. Seismic activity was first observed when mining reached Level 11 (600 m deep) and has steadily increased since then. Seismic activity is associated with the highly-stressed sill and rib pillars; no geological structures have demonstrated significant seismic potential to date. In response to this increase in activity, pillar dimensions have been increased with depth and dynamic ground support has been installed. Seismic and pressure monitoring have been implemented, among other types of instrumentation. The following paper further describes the challenges associated with using conventional methods in the high-stress environment typical of the Canadian Shield, as well as several solutions implemented to mitigate these risks.

Feb 1, 2008

By David M. R. Stone

Underground mining in the gold industry is gaining popularity in Nevada, and with it the use of cemented rockfill is becoming mainstream. Even with today?s high metal prices, however, mining companies are very sensitive to the margins they realize, and are constantly looking for ways to reduce costs or improve efficiencies. Given that the backfill is one of the largest cost centers in underground mining, mines are constantly under pressure to reduce backfill costs. This paper will present an overview of the factors that impact cemented rockfill quality in Nevada mines based on the authors many years of consulting experience. Cemented rockfill quality can be linked directly to binder consumption, hence programs aimed at improving quality generally result in lower binder costs, better performance in the fill (hence less dilution), and improved safety. The paper will conclude with the key elements of a comprehensive program of backfill quality assessments and backfill QA programs. Comparative laboratory and minesite data from a number of operating and proposed mines will be presented.

May 1, 2007

By Hajime Miki, Gde Pandhe Wisnu Suyantara, Shigeto Kuroiwa, Eri Takida, Tsuyoshi Hirajima, Masashi Yamane, Yuji Imaizumi, Mitsuru Sawada, Keiko Sasaki

Selective flotation of molybdenite and chalcopyrite using various oxidation treatments (i.e., ozone treatment, hydrogen peroxide, and Fenton-like reagent) was studied in this work. It was found that ozone treatment produced a depressing effect on both minerals, resulting in a lower separation of both minerals. On the other hand, oxidation treatment using hydrogen peroxide (H2O2) and Fenton-like reagent could deliver selective oxidation on chalcopyrite surface and depress its floatability. However, bench-scale copper- molybdenum (Cu-Mo) flotation tests show that oxidation treatment using H2O2 required a higher dosage of H2O2 and a longer treatment time in order to deliver comparable flotation results to that of conventional Cu- Mo flotation using NaHS treatment. On the contrary, Fenton-like reagent could deliver selective Cu-Mo flotation results comparable to that of NaHS treatment at a lower dosage of H2O2 and a shorter conditioning time. Contact angle measurements and X-ray photoelectron spectroscopy (XPS) analysis were employed to understand the depressing mechanism of these oxidation treatments. It was found that the chalcopyrite surface covered by various oxidation products that render the surface hydrophilic. Meanwhile, the surface of molybdenite was slightly oxidized, making the surface remained hydrophobic. INTRODUCTION Molybdenite (MoS2), the main source of molybdenum, is associated with copper sulfide minerals, mainly chalcopyrite (CuFeS2), as a trace mineral. Molybdenite is a valuable mineral and plays an important role in making the copper-molybdenum (Cu-Mo) processing plant economically viable (Laskowski, Castro, & Ramos, 2013). Therefore, it is important to recover molybdenite efficiently and effectively and separate it from copper minerals. Conventional separation of copper and molybdenum minerals is usually carried out in selective Cu- Mo flotation process using a copper depressant (i.e., sodium hydrosulfide (NaHS), Noke’s reagent, or cyanides) (Ansari & Pawlik, 2007; Bulatovic, 2007). However, this process still suffers due to imperfect molybdenum recovery. Moreover, the copper depressants use in this process are toxic and harmful to the environment. As alternative, various methods have been developed to replace these toxic and hazardous depressants, for example, by synthesizing new non-toxic or low-toxic depressants or by using various oxidation methods such as sodium hypochlorite in an alkaline medium, manganese dioxide, oxygen, and plasma pre-treatment (United States Patent Office Patent No. US 2559104 A, 1951; Patent No. US2238250 A, 1941; Barzyk, Malysa, & Pomianowski, 1981; Hirajima et al., 2014). However, the oxidation phenomenon and mechanisms are still not clear since detailed surface analyses have not done and the plasma pre-treatment method is facing technical issues for industrial scale application.

Jan 1, 2019

By Christopher W. N. Anderson

Induced hyperaccumulation of gold by plants was first reported in 1998 by researchers from Massey University in New Zealand who proposed the idea of mining gold using plants (phytomining). Since that time research has been conducted to understand the conditions under which plants can be made to take up economic amounts of the metal. One key focus has been on the geochemistry of gold-rich soils, leading to a diagnostic test that can predict how suitable a particular soil might be to gold phytomining. Field trials have been conducted at several locations around the world in collaboration with industry partners. A Decision Support System has been developed to assist in the design and management of phytomining operations, and economic modeling has been carried out to set targets levels for phytomining technology. Novel studies are now examining the form of gold in plants. Research suggests that plants may store gold as discrete metallic nanoparticles in leaf and stem tissues, an observation that may lead to new ways to recover the metal from harvested biomass.

Oct 1, 2003

By P. R. A. Andrews, R. K. Collings

"There are more than thirty-five deposits or occurrences of celestite in Canada, chiefly in Newfoundland, Nova Scotia, New Brunswick, Ontario and British Columbia. Deposits of economic interest are the Lake Enon and MacRae deposits in the Loch Lomond district of Cape Breton Island, Nova Scotia. Two Cape Breton deposits were operated from 1969 to 1976 by Kaiser Celestite Mining Limited, which supplied an upgraded celestite concentrate to an associated strontium carbonate plant at Point Edward, near Sydney.The MacRae deposit is of current interest because of its possible development for strontium carbonate production using the ""black ash"" process. This process involves chemical leaching, rotary kiln calcining with petroleum coke, washing and treatment with carbon dioxide.Celestite is the basic material used in the manufacture of strontium chemicals, principally strontium oxide, carbonate, nitrate, chromate, chlorate, chloride, sulphide and phosphate. Strontium chemicals, in turn, are used in the manufacture of glass and ceramics, in pyrotechnic devices, in the production of strontium metal and in other metallurgical applications. Recently, strontium ferrites have been introduced into permanent ceramic magnets."

Jan 1, 1991

By William Petruk

Mineralogical investigations in connection with gold metallurgy are usually performed to find the reason for poor recoveries by cyanidation or by other leaching techniques. Poor recoveries most commonly are obtained when (I) native gold is encapsulated in an insoluble mineral as "invisible gold"; (2) native gold is coated with a precipitate; (3) gold-bearing products are insoluble in cyanide solutions; (4) carbonaceous material in the ore adsorbs gold; and (5) associated minerals decompose and consume cyanide. Samples of refractory material quite often have low gold tenors. It is difficult to find the gold-bearing minerals in such samples with an optical microscope because the probability of finding trace minerals in samples is small. The probability decreases with decreasing grain size of the gold-bearing mineral and with decreas¬ing gold tenor of the sample. Techniques have been developed to increase the success rate of finding gold grains; some are (1) concentrating heavy minerals; (2) preparing special polished sections; (3) searching with an image analyzer; and (4) dissolving associate silicate and sulphide minerals.

Jan 1, 1989

By K. Hashiba, Y. Z. Liang, K. Fukui, M. Koizumi

"Efficiency and penetration rate during percussive rock drilling significantly affect the speed of tunneling and excavation. Many researchers and engineers have continuously engaged in the advancement of rock drilling performance. Development and modification of the rock drills based on test data are timeconsuming and costly. Hence it is essential to make effective use of numerical simulation. However, most of the numerical models proposed in previous studies were too simple in comparison with the actual percussive rock drilling in which many factors are involved. The objective of our research project is to construct a new realistic numerical model of continuous percussive drilling, which is based on the previous Okubo-Nishimatsu’s model. In this study, the parts of the previous model involved in stress wave propagation and attenuation were modified. The two models were prepared for HD712 hydraulic rock drill mounted on crawler drills and HD210 hydraulic rock drill mounted on drilling jumbos. Stress wave propagation was computed with the discretized one-dimensional wave equation. The calculated results were compared to the stress waves measured on a rod during percussive drilling. In both models for HD712 and HD210, the measured stress waves can be reproduced with the one-dimensional model of the same acoustic impedance as the actual piston, shank rod and rod combined with the CI+spring model as a rod joint. The calculated results indicate that the spring constant in the model of a rod joint needs to be set appropriately depending on drilling conditions. INTRODUCTIONEfficiency and penetration rate during percussive rock drilling significantly affect the speed of tunneling and excavation. Many researchers and engineers have continuously engaged in the advancement of rock drilling performance. Components related to the percussive drilling are a drill body, a piston, a shank rod, rods, rod joints, a bit and rock. The piston in the drill body is reciprocated by hydraulic pressure and collides with the shank rod a few thousand times per minute. Stress waves generated by the collision propagate and attenuate in the rods and rod joints, and then reach the bit. The bit penetrates and crushes rock. During percussive drilling, the components mutually affect each other and self-induced oscillation occurs. The number of blows and the rate of penetration are determined by the practical drilling conditions such as hydraulic pressure, thrust force, number of rods and mechanical properties of rock. Development and modification of the rock drills based on test data are time-consuming and costly. Hence it is essential to make effective use of numerical simulation. However, most of the numerical models proposed in previous studies were too simple in comparison with the actual percussive rock drilling in which many factors are involved."

Jan 1, 2015

By Peter J. Barnard

Mitochondria play a key role in the regulation of apoptosis (cell death) and in diseases characterised by abnormal apoptotic responses such as cancer. Mitochondrial membrane permeabilisation (MMP), regulated by the mitochondrial permeability transition pore complex, is widely accepted as being central to the process of cell death. As a result there has been considerable recent interest in targeting mitochondrial cell death pathways in the development of new chemotherapeutic agents.(1) There is potential to overcome the two overriding problems in cancer chemotherapy?the common occurrence of drug-resistant tumour cells and the lack of selectivity of cancer drugs in differentiating between tumour cells and normal tissues. Significantly, carcinoma cells have an elevated mitochondrial membrane potential relative to normal cells and lipophilic cations are concentrated within mitochondria in response to mitochondrial membrane potentials. There is potential for the selective targeting to tumour cells with compounds having optimal lipophilic-hydrophilic character. Research stemming from the early 1980?s points to two distinct classes of Au(I) phosphine antitumour agents where an antimitochondrial mode of action has been implicated: (i) neutral linear two-coordinate Au(I) complexes such as triethylphosphinegold(I) chloride and the tetraacetylthioglucose gold(I) phosphine complex, Auranofin; (ii) cationic tetrahedral bis-chelated Au(I) phosphine complexes related to [Au(dppe)2]+.(2) Recently it has been reported that Auranofin, at submicromolar concentrations, induces MMP observed as mitochondrial swelling and dissipation of membrane potential.(3, 4) Both events are completely inhibited by cyclosporin-A, the specific inhibitor of MMP. The permeability changes were shown to occur at concentrations associated with the selective inhibition of mitochondrial thioredoxin reductase.(3) Auranofin is a potent and specific inhibitor of this enzyme due to Au(I) binding to the active-site selenol group.(5) The redox state of mitochondrial thiols may be critical in the control of MMP.(3) In general, swelling is stimulated by thiol blocking or oxidising agents and is prevented by thiol reducing agents.(1) Mitochondrial thioredoxin reductase may play an import role in the redox control of the permeability of mitochondrial membranes.(3) Our interest is in investigating the antitumour potential of Au(I) phosphine compounds using a number of different approaches. In recent work we have evaluated a series of hydrophilic analogs of [Au(dppe)2]+ containing pyridylphosphine ligands which have demonstrated greater tumour selectivity than the parent compound. To investigate the possible antimitochondrial mode of action we are studying the effect of [Au(dppe)2]+ and related compounds on isolated rat liver mitochondria. To assess whether the lipophiliccationic nature of the compounds determines the antitumour activity, we have synthesized a series of novel Au(I) complexes based on heterocyclic carbene rather than phosphine ligands. The similar chemistry and structural features of the two classes of complexes allow us to assess whether the phosphine ligands are essential for the antitumour properties.

Oct 1, 2003

By M. D. Viera

The purpose of the study is to show, through real cases of companies in Chile, the different problems concerning valuing or economically appraising a mining ore resource with the traditional techniques. The study demonstrates that, with the risk analysis and real options theory application, one could determine the most probable value for a mining resource or mining business, and the risks cover of uncertainty scenarios. The study discusses different methods and criteria employed in the ore resource evaluation or mining assets. It also shows a comparative analysis of the different methods in order to explain various distortions, errors, risks and imprecisions of each of them. the companies are becoming aware of the risks' importance and the impact they have on the commercial value and resource estimation models. Now, the real options are the techniques that somehow make it possible to value and control the risk cover of the business. The company valuation could help respond questions like: ? How much is my business worth? ? How much has the investment profitability of my business been? What could be done to improve this profitability and create value?

Jan 1, 2007