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By P. R. Miles, J. K. H. Ma, J. Y. C. Ma, L. Bowman

"The bisbenzylisoquinoline alkaloids are compounds which can be isolated from plants and which exhibit a broad range of pharmacological activities. Perhaps the best known alkaloid of this group is tetrandrine (TT), a compound isolated from the root of a traditional Chinese medicinal herb, Stephania tetrandra. It has been tested for its effects on the cardiovascular system, tumors, and the lungs. For example, tetrandrine has been shown to act as a calcium entry blocker in cardiac sarcolemmal vesicles (King et a/., 1988) and has been used in China as a treatment for angina and hypertension. Its possible effects as a tumor-inhibitory substance have also been investigated (Kupchan and Atland, 1973). In addition, there are several lines of evidence to suggest that it is a possible therapeutic agent for the treatment of silicosis. Yu et a/. (1983) have shown that TT inhibits the development of experimental silicosis in rats when it is administered orally after intratracheal instillation of quartz. Other studies have shown that the alkaloid inhibits the synthesis of collagen by fibroblasts and the formation of silicotic nodules in rats exposed to silica (Huang et al., 1981; Liu et al., 1983). In fact, tetrandrine has been used clinically in China as an antifibrotic agent and has been shown to improve both the appearance of chest radiographs and the measurements of diffusing capacity in patients with silicosis (Li et al., 1981).Since tetrandrine may have a potential use as a therapeutic agent for fibrotic lung diseases, its effects on various pulmonary cells and tissues should be studied. Alveolar type II cells are located in the alveolar regions of the lungs and are important because they are responsible for the synthesis and secretion of pulmonary surfactant (Dobbs et al., 1982; King, 1984), regeneration of the alveolar epithelium after lung injury (Kauffman et al., 1974), and metabolism of foreign compounds (Bend et al., 1985). Furthermore, in silicosis, for which TT has been suggested as a treatment, there are increased amounts of pulmonary surfactant produced (Dethloff et al., 1986a,b) as a result of increased rates of surfactant synthesis by type II cells (Dethloff et a/., 1989; Miller et al., 1988). Because type II cells play a critical role in maintaining normal lung function and because type II cells are affected in silicosis, for which 'TT has been used as a treatment, we studied the effects of tetrandrine on energy metabolism in these cells in vitro. Energy metabolism was chosen because it is a basic cellular function which is neces-sary for other cellular processes to occur. Since type II cells depend on mitochondrial metabolism for energy production (Fisher et al., 1980), we examined the effects of tetrandrine on cellular and mitochondrial ATP production and oxygen consumption. Additional experiments were performed in an effort to determine if intracellular calcium levels may be involved in the TT-induced effects. A preliminary report of those results has appeared previously (Ma et al., 1991)."

Nov 1, 1995

By Martin D. Conyac

Results of the minerals survey indicate low potential for the discovery of placer gold along Deck Creek aid for copper, silver, and gold in PreTertiary rocks within the boundaries of the Lake Fork RARE II area. Potential for oil, natural gas, coal, and geothermal resources is negligible. No evidence of economic mineral resources was found during the examination of the study area, and no assays of rock or placer samples taken from the urea showed economic mineral values. There are no producing or developing mines within the boundaries o of the lake Fork study area. SETTING Mining Districts The Lake Fork RARE II area is on the eastern fringe of the Cornucopia Mining District, which is centered about 6 mi west. It is also on the western edge of the Homestead district, centered about mi east.

Jan 1, 1983

Electrical trailing cables are frequently damaged in usage, especially on continuous minors, and because of their weight and damaged condition present a safety hazard to personnel required to handle them. The U.S. Bureau of Mines and FMC Corporation signed Contract No. HO 122011 in August 1971. One of the contract tasks was to study the feasibility of techniques to improve trailing cable support and handling of power cables on underground coal mine machinery and to design a cable-handling device for a continuous mining machine. This report presents the results of the feasibility study, describes the design for a proposed cable handling device and concludes with a recommendation for future action to construct a test rig to evaluate the cable reel system.

Jan 1, 1972

By H. E. Peterson

This report revises an earlier publication by the Bureau of Mines on tungsten analytical procedures and expands the coverage by including appropriate procedures for the critical impurity elements that commonly occur in tungsten ores and concentrates (13).3 The basic methods described are not original, but many of the modifications to improve reliability and sensitivity were developed by the Bureau. Gravimetric and colorimetric methods currently used for the determination of tungsten in ores, mill tailings, and concentrates are described. Colorimetric procedures are preferred for low concentrations of tungsten, whereas either procedure is satisfactory for moderate concentrations. Conversely, a gravimetric method is preferred for the determination of tungsten in concentrates.

Jan 1, 1963

By John R. Hoskins

The Bureau of Mines conducted an investigation to more exactly define the influence of some end conditions on the laboratory-determined uniaxial compressive strength of rock samples. Limestone, marble, sandstone, and granite were used to provide a range of specimen modulus of elasticity from 2.7 X 106 psi to 10 x 106 psi. Four variables were studied: Nonparallelism and surface texture of specimen ends were the specimen variables investigated; the end platen size and the adjustable or spherical head friction were the machine variables studied. It was concluded that the loading ends of small laboratory models and samples should be prepared with surface irregularities that do not vary from a plane surface by more than 0.001 inch. It was also concluded that nonparallelism of the specimen ends should not exceed 8 minutes for a rigid head load or 15 minutes for an adjusting head load. The measured compressive strength of specimens prepared with these tolerances will be statistically the same with any diameter or thickness of platen and any degree of head friction if initial alinement of the specimen is assured.

Jan 1, 1968

By Lloyd A. Morley

A guide to the development and use of an APL computer program for the analysis of load-flow problems is presented. The program is designed to provide an interactive method of load-flow study to improve underground coal mine electrical system design and safety. The theoretical basis for load-flow analysis is discussed, along with per-unit calculations which facilitate computation. Specific input/output, execution and network modification procedures are presented for using the APL program. In addition, typical results are given for examples taken from power system analysis literature.

Jan 1, 1977

By Nancy Estrada, Jane Nowell, Cathy Jennings, Debra Yniguez, Carol Lavery, Kristin Harrer

Pilots of the MH-60S helicopter are exposed to continuous whole body vibration (WBV). Pilot fatigue is a growing operational concern due to the increased frequency of extended durations of missions (6-8+hours) in support of Operations Iraqi Freedom and Enduring Freedom. Endurance aspects of the currently used rotary wing seating systems were not optimized for the longer missions and wide range of pilot anthropometric measurements, which is now typical of naval aviation. The current seating systems were designed primarily to meet crashworthiness requirements, not for the wide range of pilot anthropometry or to mitigate WBV. Albeit, an issue, pilot fatigue and reduced mission effectiveness are also critical concerns. Current Hazard Reports indicated that pain in pilots’ legs and backs begin two to four hours into the flight and increase with time. Mission readiness also decreases with an increase in flight duration due to the constant distraction of pilots shifting in their seats while trying to get comfortable. Froom, et al [2] reported a dose-response relationship between the length of military helicopter flights and back discomfort. He also concluded that this pain is typically dull, over the lower back, and its prevalence and intensity are dependent on the total flight hours of exposure. Methods This study evaluated WBV produced in the pilot seating systems onboard the MH-60S. The purpose of the study was to test and compare the effectiveness of two different seat cushions, the current seat cushion versus an anti-vibration seat cushion. Both seat cushions were measured for acceleration levels averaged over five-minute intervals using a triaxial seat pad accelerometer. The recordings were completed for a 3-hour straight and level flight. A frequency analysis from 0-80 hertz (Hz) was conducted on all acceleration measurements to determine the dominant axis and frequency of the pilots’ vibration exposure. The results were then compared to the applicable Threshold Limit Values (TLVs) established by the American Conference of Governmental Industrial Hygienists (ACGIH) [1] and the International Organization for Standardization (ISO) 2631.1 [3] to determine the MH-60S pilots’ permissible exposure time for both seat cushions. Results The results of the study showed that for both seat cushions the vibration levels of the z-axis at 16 Hz had the shortest allowable exposure duration, according to the ACGIH TLVs. In the z-axis at 16 Hz, the MH-60S’s current seat cushion’s acceleration levels indicated an exposure time limit of approximately 6 hours, while the anti-vibration seat cushion’s acceleration levels pierced the 8-hour exposure time limit curve. This is shown in the graph below.

Jan 6, 2006

Develop an alternative to water bath exhaust conditioners (water scrubbers) for permissible diesel equipment used in gassy mines. Background Water scrubbers are a safety device used on diesel-powered vehicles in gassy mines. Exhaust from the engine passes through the scrubber, where it is cooled, and any flames or sparks present in the exhaust are extinguished. This prevents the ignition of combustible mine dust or methane that may be present. Unfortunately, water scrubbers consume large amounts of water and require frequent maintenance. Approach Methods that do not require water replenishment and frequent maintenance were investigated. The dry exhaust conditioning system was selected for investigation because no water is consumed and existing heat exchanger technology can be adapted to underground mine vehicles. In accordance with U.S. Mine Safety and Health Administration (MSHA) requirements, the system was designed to cool exhaust and trap flames and sparks. The U.S. Bureau of Mines (USBM) developed and evaluated a system for large engines and evaluated a second system for smaller engines. Both systems were evaluated on an engine test bed; if warranted, the system was then tested underground.

Jan 1, 1993

By Brian T. Brady

The year 1992 recorded unimpressive economic growth and uncertainties over what changes would occur for the financial market. Falling interest rates in the United States and elsewhere tended to exert a number of positive influences on financial markets and, indirectly, the mining and quarrying industry. The interest rate declines during 1992 were no exception. Lower rates prompted many investors to turn their attention to long-term investments such as stocks that offer potentially greater rates of return, causing large cash inflows into the equity market. Lower rates made it easier for businesses to finance growth and for consumers to finance the purchase of products businesses made. Also the rates enabled many companies to increase their health and profitability by refinancing their existing loans at lower rates. Falling interest rates were not confined to the United States. With Japan and Western Europe in the midst of economic slumps, marketing authorities in many countries overseas lowered rates in an effort to stimulate business activity. True to form, that contributed to stock market rallies abroad. Stabilizing inflation and lower interests stimulated the industry during 1992 and will likely influence favorably the industry for the next few years.

Jan 1, 1992

By Robert P. Vinson, Kissell. Fred N., Edward D. Thimons

"The Bureau of Mines investigated the presence and extent of methane accumulations in mine roof cavities using a full-scale mine model. Methane was released at a constant rate into the roof of a cavity built onto a 700-ft wind tunnel. Two box-shaped roof cavities were used in the study: one had a volume of 114.7 cu ft; and the other had a volume of 57.3 cu ft. Methane concentration was measured at 28 sampling points in the cavities using 21 different combinations of gas emission rates and air velocities. Brattice hung in the cavity helped reduce methane concentrations without auxiliary ventilation. It was also found that the effective ventilation rate increased by a factor of 40 in the large cavity and by a factor of 20 in the small cavity when air velocity was increased from 100 to 600 fpm.INTRODUCTIONAny location in a coal mine where 5 pct or more of methane is present constitutes a potential site for an explosion and roof cavities are likely locations. Unfortunately, little is known about the buildup of methane in roof cavities. Some research has been done using scale models where no air flows past the cavity so that methane disperses only by diffusion (5) 4 a rare situation in mines.No known cavity-model investigations have been made that simulate air and methane flow conditions normally encountered underground. These Bureau of Mines studies were undertaken to determine the extent and manner of methane buildups in coal mine roof cavities with air velocities in the range normally found in coal mines and with various methane emission rates."

Jan 1, 1978

By R. G. Meara, O&apos

[P.F? bmit e-ninirq ir.3.l r;tq: in the Znited State :; was u~irlyortant p~ior to the Torld ;Jar, ?-.lt with the c~r,sxti~rl of imports d11rln.c thr World 'Jar tke Rmericnn mar~factu~er:. of 1itkopone mcl Sayiun c;~oai?als forced tile tl~veloor?.ent of domertic bar,i$e dqosit9. Pr%~~,n-ily bcca-lse of tho increasing dc.n;;nl'i for lit,hupone3 by the pr?i:~t, Tlocr-covcrin~;, ,md rt1tbe.r indl~stries, ~3c.vs1o~:rnc2t of cto~entic de~onits has cr~ntim~ed to c-cpand. 13 1914, the salnr! oC doxegtic c~l~.dt? t,m-it~ ;u~cr-~nteii. to 52,91? tons, in 1237 ???,1!.1 tons nmre so1.d; thc 12:t~r rcyrprcntcd 77 .E;T pmccnt of the tot,:rl, dr??;ectic and imortcd., haritd US~C in the Cnited State? di7rinz t,hat :.vXr. C,f +he total 193,3:& ton? coy.1~-ed in the United 4 Steter ir. 135, 3E.X percent v;as usec? as groi.z.ld ~rai.te? , "0.3 percent arr lithopone, and 17 .:A ].ercc?t in the rnx 11fact,ure of b;~riim chs:nicals . ]

Jan 1, 1938

By John F. McCoy

The United States Bureau of Mines (USBM) awarded a contract to Foster-Miller Associates, Inc. (FMA) to develop guidelines for designing, constructing, stocking and maintaining rescue chambers in underground mines. This report develops information and recommendations which could be used by a mine operator who desired to install a rescue chamber. Volume I covers the following major areas: atmospheric life support, configuration and construction, chamber location, power and lighting, equipment and supplies, communications, and psychological aspects and training. Volume II contains the following appendices: History of Barricading, Chamber Pressurization Considerations, Diffusional Infiltration of Gas, Compressed Air Storage, Location Examples, and Psychological Aspects.

Jan 1, 1983

The Bureau of Mines studied blast-produced ground vibration from surface mining to assess its damage and annoyance potential, and to determine safe levels and appropriate measurement techniques. Direct measurements were made of ground-vibration-produced structure responses and damage in 76 homes for 219 production blasts. These results were combined with damage data from nine other blasting studies, including the three analyzed previously for Bureau of Mines Bulletin 656. Save levels of ground vibration from blasting range from 0.5 to 2.0 in/sec peak particle velocity for residential-type structures. The damage threshold values are functions of the frequencies of the vibration transmitted into the residences and the types of construction. Particularly serious are the low-frequency vibrations that exist in soft foundation materials and/or result from long blast-to-residence distances. These vibrations produce not only structure resonances (4 to 12 Hz for whole structures and 10 to 25 Hz for mid walls) but also excessive levels of displacement and strain. Threshold damage was defined as the occurrence of cosmetic damage; that is, the most superficial interior cracking of the type that develops in all homes independent of blasting. Homes with plastered interior walls are more susceptible to blast-produced cracking then modern gypsum wallboard; the latter are adequately protected by a minimum particle velocity of approximately 0.75 in/ sec for frequencies below 40 Hz. Structure response amplification factors were measured; typical values were 1.5 for structures as a whole (racking) and 4 for midwalls, at their respective resonance frequencies. For blast vibrations above 40 Hz, all amplification factors for frame residential structures were less than unity. The human response and annoyance problem from ground vibration is aggravated by wall rattling, secondary noises, and the presence of airblast. Approximately 5 to 10 pct of the neighbors will judge peak particle velocity levels of 0.5 to 0.75 in/sec as "less than acceptable" (i.e., unacceptable) based on direct reactions to the vibration. Even lower levels cause psychological response problems, and thus social, economic, and public relations factors become critical for continued blasting.

Jan 1, 1980

By D. Harrington

"Coal—mine explosions are accidents that can and should be prevented. In former years hundreds of lives were lost each year in the United States as a result of such explosions, but after 1932 the numerous precautionary measures adopted had reduced their frequency and severity 75 percent or more until in 1940 several very disastrous explosions marred the good record. Unfortunately, both the number and severity of explosions seem to be tending to increase compared with the relatively good achievement from 1933 to 1940. The requisites for an explosion are ever present in all soft-coal and many hard-coal mines. A certain combination of circumstances, such as a flame or an arc in a cloud of dust or in a body of gas or both may start an explosion at any time. The fact that the frequency and severity of explosions were lowered for 6 or 7 years is no guarantee that such freedom from explosions will continue, as the bad record of 1940 has shown, and underground workers should feel honor bound to exercise the utmost care so that they will not help to bring about the circumstances that will cause an explosion.Although mine operators bear the main responsibility for preventing explosions, miners can do many things to help. As about 9 out of 10 explosions begin at a working face, it is largely within the power of workers to prevent them. All miners should do their part willingly and should not defend a fellow workman from punishment, even from discharge, for disobeying necessary rules, whose disregard may cause the death not only of the safety-rule breaker but also of many of his coworkers.When a miner is careless and is injured some other way than by an explosion he may be the only one to suffer, but if his carelessness causes an explosion he not only endangers his own life but also that of every other man in the mine and possibly the lives of persons outside the mine.Experiments have shown that ignition of as small a quantity as 150 cubic feet of an explosive mixture of methane and air under certain circumstances can start an explosion that will traverse an entire mine. Thus, ignition of an explosive mixture of gas 1 foot down from the roof and 13 feet back from the face of a 12-foot entry might cause a widespread explosion if the right quantity and kind of dust were present. Many persons have ignited much larger quantities of gas without being killed, but they survived only because dust, confinement, and other conditions were not exactly ""right."""

Nov 1, 1940

By John M. Devine

Hydrogen sulphide associated with natural gas was noted as early as at Point Albino, Canada. The presence of this impurity was recognized also in other of the earlier oil and gas fields, although the occurrence was by no means common. However, in recent years, with the development of the producing zones of test Texas and the Texas Panhandle, the Production of "sour" crude has increased greatly and hydrogen sulphide has proved a generally troublesome factor--frequently a major problem--in the drilling and operation of many wells in those areas. The problems arising from the drilling and producing of oil or gas wells in hydrogen-sulphide areas, fall under two general divisions: safety problems and corrosion problems. Mention is made of a third division which is closely related to the other two, that of treating--or the development of processes for the removal of hydrogen iron the standpoint of safety and health hazards, hydrogen sulphide in the petroleum industry has been discussed in a number of publications. Likewise, the problem of hydrogen-sulphide corrosion of production equipment has been given considerable attention in the literature.

Jan 1, 1931

By John M. Devine

Hydrogen sulphide associated with natural gas was noted as early as 1892, at Point Albino, Canada.4 The presence of this impurity was recognized also in other of the earlier oil and gas fields, although the occurrence urea by no means common. However, in recent years, with the development of the producing zones of west Texas and the Texas Panhandle, the production of "sour" crude has increased greatly and hydrogen sulphide has proved a generally troublesome factor--frequently a major problem--in the drilling and operation of many wells in those areas. The problems arising from the drilling and producing of oil or gas wells in hydrogen-sulphide areas, fall under two general divisions: safety problems and corrosion problems. Mention is mane of a third division which is closely related to the other two, that of treating--or the development of processes for the removal of hydrogen sulphide. From the standpoint of safety end health hazards, hydrogen sulphide in the petroleum industry has been discussed in a number of publications. 5 Likewise, the problem of hydrogen-sulphide

Jan 1, 1931

By R. G. Meara, O&apos

[P.F? bmit e-ninirq ir.3.l r;tq: in the Znited State :; was u~irlyortant p~ior to the Torld ;Jar, ?-.lt with the c~r,sxti~rl of imports d11rln.c thr World 'Jar tke Rmericnn mar~factu~er:. of 1itkopone mcl Sayiun c;~oai?als forced tile tl~veloor?.ent of domertic bar,i$e dqosit9. Pr%~~,n-ily bcca-lse of tho increasing dc.n;;nl'i for lit,hupone3 by the pr?i:~t, Tlocr-covcrin~;, ,md rt1tbe.r indl~stries, ~3c.vs1o~:rnc2t of cto~entic de~onits has cr~ntim~ed to c-cpand. 13 1914, the salnr! oC doxegtic c~l~.dt? t,m-it~ ;u~cr-~nteii. to 52,91? tons, in 1237 ???,1!.1 tons nmre so1.d; thc 12:t~r rcyrprcntcd 77 .E;T pmccnt of the tot,:rl, dr??;ectic and imortcd., haritd US~C in the Cnited State? di7rinz t,hat :.vXr. C,f +he total 193,3:& ton? coy.1~-ed in the United 4 Steter ir. 135, 3E.X percent v;as usec? as groi.z.ld ~rai.te? , "0.3 percent arr lithopone, and 17 .:A ].ercc?t in the rnx 11fact,ure of b;~riim chs:nicals ]

Jan 1, 1938

By H. L. Riley

At the Southern Experiment Station, Tuscaloosa, Ala., reports are prepared from time to time on results of washability studies of coal from important beds in the Southern Appalachian region. The investigations that provide the material for these reports are made by the Bureau of Mines, United States Department of the Interior, in cooperation with the University of Alabama and the mine operators. The principal objective of a washability study is to obtain technically and commercially important data to aid in determining the best methods for preparing and utilizing the Nation's reserves, particularly of coking coals. Such information is also important from the standpoint of conservation, because it facilitates the selection of preparation methods that will yield an acceptable product with a minimum loss of coal to the rejects.

Jan 1, 1958

Provide the mining industry with a simple, accurate and readily available means of measuring the gas flow from pipe outlets such as gob holes Approach The Bureau of Mines conducted laboratory studies to establish correction or method factors for anemometers when used to measure gas flow from pipe outlets. Using the Anemometer Anemometers are used by the mining industry to make air velocity measurements in mine entries. Although the instrument has no appreciable influence on the airstream in mine entries, especially since the cross-sectional area of an entry is much larger than the cross-section of the anemometer, correction or method factors are used to correct the center line anemometer velocity to average velocity. This adjustment is made because the air velocity in a mine entry is highest in the center and lower at the sides. Anemometers can be used to measure gas flow from small diameter pipe outlets; however, since the instrument diameter is much larger than one-sixth of the pipe diameter, it will influence the air-stream from these small outlets. Resulting velocity measurements are erroneously high by as much as 30 percent. Method factors must be applied to such anemometer measurements taken at pipe outlets. Through a research investigation the Bureau of Mines established a set of method factors for center-line anemometer readings taken at the discharge end of 4-to 8-inch diameter pipes. These method factors were combined with method factors which were developed by the National Coal Board of Great Britain for 12-to 30-inch diameter pipes. The anemometer was mounted on the end of a short rod and held against the pipe for support except on the 4-inch pipe where the instrument was started and stopped remotely to prevent hand interference with the air-stream during measurements. Method factors were determined by comparing the anemometer measurements at the pipe outlet to the true average airflow which was simultaneously determined upstream by venturi measurements. Consequently, a method factor is nothing more than the ratio of the true velocity to an anemometer measurement.

Jan 1, 1987

By C. Ogasawara

This document describes the direction and progress of the Bureau of Mines Oil Shale Mining Environmental Research Program as of January 31, 1979. It is aimed at focusing the Bureau's role in environmental research supporting oil shale development with respect to the activities of other involved government agencies and private industry. Environmental considerations in oil shale extraction, such as ecological disturbances, health and safety hazards, waste management, and socioeconomic impacts, are discussed along with the type of research known to be planned by organizations to ameliorate these problems.

Jan 1, 1979