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By R. Hewer

Transition metals have been widely used in medicine throughout history. The medicinal use of metals extends back to the earliest recorded history when the Chinese used gold as treatment for a variety of ailments. The ancient Egyptians used copper to sterilize water and mercury was reportedly used by Hippocrates in 400BC. Thereafter, numerous other metals have been used as treatment throughout the centuries. For example, zinc sulphate was used as an emetic in the 17th century and zinc oxide was used to treat epilepsy in the 18th century. This use of metals, and numerous other instances, which have been well described in Sneader 2008,1 make for interesting reading but largely occurred prior to the advent of rigorous scientific method. Therefore, although there are exemptions, most therapeutic applications of metals prior to the modern age lack scientific grounding and have been found to be mostly ineffective. Of more relevance are metal-based medicines approved by regulatory bodies (i.e. Food and Drug Administration; FDA) that are in current use as therapeutic drugs. There are presently a large number of metal-based drugs that are approved for use by the FDA ranging from over the counter medicines, such as bismuth subsalicylate for gastrointestinal problems, to prescription drugs such as lithium carbonate for the treatment of manic depression. The list of metal-based medicines approved by the FDA not only incorporates base metals but also includes precious metals. Platinum complexes have been found to be potently active against several different types of cancers while gold complexes have shown application as treatment for rheumatoid arthritis (RA). With the well-established foundation that exists for metal-based medicines, it is imperative to continue exploration into new therapeutic areas. The precious metals; gold, ruthenium and platinum, continue to attract scientific interest in the field of biomedicine and have been widely researched. Scientific studies conducted on gold complexes have demonstrated the potential of this metal for the treatment of HIV/AIDS, cancer and malaria. These diseases are also specific health concerns for developing nations; countries where disease has devastating impact. Within South Africa alone, an estimated 5.7 million people are infected with HIV/AIDS,2 approximately 7 000 new cases of malaria are reported annually, and it is projected that 1 in 4 persons will develop cancer. Continuous development of therapeutic drugs to combat these diseases is therefore apriority, and the exploration of gold-based compounds for this purpose is warranted.

Jan 1, 2009

By Baruch Grinbaum, Edwin Bwalya, Robert Minango, Deogratias Bukunkwe

Solvent extraction of Cu from acidic leach, using an oxime extractant, e.g. LIX 984 or Acorga is a well known and established process. As the process advances, Cu is extracted to the solvent and is replaced by H+ in the aqueous phase. At high acidity the distribution coefficient of Cu between the solvent and the aqueous phase decreases, and eventually relatively high concentration of Cu remains in the raffinate, regardless of the number of equilibrium stages. In many processes this phenomenon is immaterial, as the raffinate returns to the leaching and no copper is lost. But when the copper raffinate is used for processing of additional metals, minimal concentration of Cu in the raffinate is essential for an effective process. The recommended process includes three steps: 1. SX-1: Standard extraction of Cu with oxime. The resulting raffinate contains about 6-8 g/L Cu and 50 g/L H2SO4. 2. SX-N: Extraction of most of the acid into an amine-based solvent, and stripping it with a base, e.g. aqueous ammonia, caustic, Na2CO3 etc. The extraction removes no metals, but decreases the concentration of acid from 50 to 10 g/L. 3. SX-2: Extraction of the neutralized solution once more with oxime, to remove the residual copper. Such a process enables one to get down to 100-150 ppm Cu in the final raffinate. This process was developed and tested in the R&D facility in Chambishi Metals plc, by a joint team of Chambishi & Bateman, using Cognis LIX 984N and real solutions from the plant. In the laboratory scale, the equilibrium isotherms for SX-1, SX-2 and the neutralization were developed. Computer simulation of the results showed that the optimal configuration is two stages for both extraction and stripping for SX-1. For SX-2 2-3 stages of extraction and two stages of stripping are needed. The stripping stages may be common to both SX-1 and SX-2. The neutralization of SX1 raffinate was tested both by conventional precipitation with lime and by extraction with Alamine based solvent extraction and stripping with a solution of 10% NaOH. For the SX-N only one stage was needed for both the extraction and stripping. The bench scale pilot plant was run for both SX-1 & SX-2. The results were very similar to the simulated ones, and the configuration of 2E2S for SX-1 and 3E=2S for SX-2 delivered the required raffinate with less than 150 ppm Cu.

Jan 1, 2005

By W. H. Holtzhausen

The purpose of this project was to compare two underground, batch coal haulers ? battery haulers and shuttle cars ? in order to determine the more viable machine to implement. The specific standards for battery haulers were investigated and compared to the requirements of shuttle cars in order to identify the unnecessary expenses related to the legal requirements that are attached to the machines. Costs such as running costs, capital costs, and maintenance costs were researched and compared over a typical life of machine. Average production rates and breakdown times were obtained and used to determine which machine would be more reliable in achieving the required annual production.

Jan 1, 2014

By C G. Robinson, B. K. Loveday, J. C. Paynter

"A method of optimizing the design of a processing plant has been developed which minimizes capital and operating costs for average stripping ratios and ore characteristics. Models were developed to describe the operating characteristics and costs involved in various operations such as up-grading, leaching and solid-liquid separation.The options available in up-grading policy and the relation between the cut-off grade and the costs incurred subsequently in the treatment of the ore formed the basis of the optimization. To arrive at an optimum plant configuration and a set of operating parameters, the interrelation between grinding size, leaching temperature, leaching time, and various plant recycle options was investigated."

Jan 1, 2014

By B. K. Loveday

A Colloquium on 'Control and Simulation in the Minerals Industry' was held at the Holiday Inn, Milner Park, on 20th September, 1984, in conjunction with the Electra Mining Exhibition. A total of 170 persons attended the very full morning programme, which began with an opening address by the President, The South African Institute of Mining and Metallurgy, Mr l.D. Austin. He outlined the reasons why computers were being used to an ever-increasing extent for control and simulation in the minerals industry. The computer was even used to check, among other things, the validity of the signals it was receiving by mass-balance calculations.

Jan 1, 1985

By N. B. Strydom, P. L. Jooste, H. F. Kotze, W. H. Van Der Walt

Note: A revised method of heat acclimatization by N. B. STRYDOM, W. H. VAN DER WALT, P. L. JOOSTE, and H. F. KOTZE INTRODUCTION Climatic-room acclimatization was introduced in the gold-mining industry in 1965 and was rapidly adopted by all mines because it reduced the number of days required for heat acclimatization from 12 to 8. The method has been adequately described in previous papers1, 2 but, briefly, requires four hours of heat exposure per day while the work rate is progessively increased from 35 W on Day 1 to 70 W on Days 7 and 8. Several attempts to shorten

Jan 6, 1976

By P. M. Scott

The South African Institute of Mining and Metallurgy held a colloquium on 'The Selection of Equipment for Underground Mining' in Johannesburg on 22nd September, 1982, which, judged by the interest shown, was an unqualified success. Mintek 50 As announced earlier, the Council for Mineral Technology (Mintek) will be celebrating fifty years of growth in 1984 and is organizing an international conference, MINTEK 50, on its areas of special expertise. Drilling Once again the South African Drilling Association will be holding a technical symposium in 1983. ILAFA Congresses The Instituto Latinoamericano del Fierro y el Acero (ILAFA) has scheduled the following congresses for 1983:

Jan 1, 1983

By A. C. Coetzee

Blinkpan Koolmyne is as ten voile gemeganiseerde steenkoolvoorsiener aan die 1 000 MW Evkom-kragsentrale in die Oos-Transvaal, onderhewig aan groat seisoenale produksieskommelinge. Die aanwending van 'n groat bogrondse oap opgaarhoop vir die uitstryking van hierdie wisselende aanvraag word beskryf. Twee produksierasionaliseringsfases wat hierop volg het besondere bemoedigende resultate gel ewer, beide in toerusting- en mannekrag-produktiwiteit. Die aanwending van 'n rekenaarprogram vir die simulering van ondergrondse afbouaktiwiteite met die oog op toerustingkeuse, word aangegee. Voorlopige resultate wat in die praktyk behaal is dui op 'n hoë mate van betroubaarheid vir die program, terwyl die gebruik van die nuutste tipe hoë -kapasiteit laaimasjiene, koolsnyers en wisselkarre, groat potensiaal inhou.

By J. Meintjest

As you pointed out, furnace power factor (and consequently transformer MVA rating) depends upon the inductive reactance, and so it is desirable to design for the lowest possible value of this parameter. The further introduction on the primary side of the transformer of capacitors, whether in shunt or in series, increases the network power factor but does not alter the furnace power factor; that is, the phase angle between electrode to- hearth voltage and current remains unchanged. Corrigenda The following amendments should be made to the article entitled 'Coal-preparation routes for maximum coal recovery', which was published in the August issue (vol. 80, no. 8) of this Journal:

Jan 1, 1980

Infacon 74 Members are reminded of the International Ferro-Alloys Congress that is to take place in Johannesburg between 22nd April and 1st May, 1974. The Congress is being held jointly by the National Institute for Metallurgy, the Ferro Alloy Producers' Association of South Africa, and the South African Institute of Mining and Metallurgy. Correspondence and enquiries should be addressed to The Secretary, Organizing Committee, INFACON 74, Private Bag 7, Auckland Park 2006. The gold deposits of the farms Lisbon and Berlyn in the Eastern Transvaal by v. c. H. R. BRERETON. Published in the Journal November 1973. AUTHOR'S CORRECTIONS The following amendments should be made.

Jan 2, 1974

This paper describes the operating practice and design features of an intensive-cyanidation plant at the East Gold Plant of Vaal Reefs Exploration and Mining Company Limited (V.R.E.M.). After the development oh cyanidation route for the treatment of gold-plant gravity concentrates by the Anglo American Research laboratories (A.A.R.L.), a full scale plant was commissioned at Western Holdings (Welkom Division) Gold Mine in March 1977, and the V.R.E.M. plant was commissioned in August 1981. Although the gravity-concentration route does not now enjoy the prominence of former times, in an existing conventional plant the intensive-cyanidation route can successfully replace mercury amalgamation.

Jan 1, 1984

By C. T. Connor, O&apos

The fifth University of Cape Town (UC1)/University of Stelenbosch (US) Minerals Processing Symposium was held at the Faculty of Engineering, University of Stelenbosch on Friday, 8th August, 1986. This series was initiated in 1982, the symposia being held alternately in Cape Town and Stelenbosch. The South African Institute of Mining and Metallurgy has kindly agreed to sponsor this event for the next three years. Cokemaking On the initiative of the European Cokemaking Commitee, the First International Cokemaking Congress will be held in Essen (F.R. Germany) from 13th to 19th September, 1987. It is being organized by the Steinkohlenbergbauverein, together with the Verein Deutscher Eisenhitenleute.

Jan 1, 1986

By P. H. Botha

An account is given of the procedures used by the South African Iron and Steel Industrial Corporation (Iscor) for tests on the flotation of coal fines, and some of the beneficiation problems encountered with coal from Durnacol, Grootegeluk, and the Soutpansberg area are discussed. These, and other South African coals differ from overseas coals in that they contain a high percentage of fixed ash, which means that they have to be crushed more finely for liberation and that they then contain more fine material (smaller than 0,84 mm). In addition, the coal from the three areas mentioned occurs in fine layers and seams, and contains many intergrown particles.

Jan 1, 1980

By R. J. Mostert

The role of hardenability in the development of high-strength low-alloy (HSLA) steels is discussed. The applicability of the superhardenability treatment. a steel making technique for increased hardenability, to HSLA steels is indicated, and the literature on this treatment is reviewed. Several low-carbon superhardenability HSLA steels were designed by use of published superhardenability multiplying factors. It was found that the hardenability of these low-carbon steels can be increased to the same extent as that of medium-carbon steels. The mechanical properties as determined in normalized bars indicate that the superhardenability treatment can be used successfully in the production of low-carbon hot-rolled HSLA steels.

Jan 1, 1984

By I. J. Barker, D. A. Vetter, G. A. Turner

The modeling of the uranium-leaching process, and the logging of data from a plant for the evaluation of the model, are reported. A phenomenological approach was adopted in the development of the model. A set of eight chemical reactions was chosen to represent the complex chemistry of the process, and kinetic expressions for these reactions were incorporated in differential equations representing mass and energy balances. These equations were coded in FORTRAN to form a program that simulated the process, and that allowed averaged and continuous data from the plant to be compared with the model. This allowed the model to be 'tuned', and to reveal a number of minor

Jan 1, 1989

PREFACE During the past year, considerable effort was devoted to the implementation of the strategic plan that was adopted by the SAIMM in 1986. Good progress was made in a number of areas, while in others the foundation was laid for future progress. Key Objective of the Institute The key objective of the SAIMM is as follows: To identify the needs of its members and to initiate and give effect to the means whereby the requirements for technology and scientific knowledge of the minerals and metals section of the South African economy are satisfied; and to represent and promote the interests of its members.

Jan 1, 1987

By M. J. Nicol

This paper ,examines the kinetics of the extraction of uranium from acid sulphate solutions by strongbase anionexchange resins. Parameters such as the concentration of uranium in solution. the agitation of the resin beads in solution. the size of the resin beads. and the degree of cross-linking within the resin matrix were varied. and the effec ts on the kinetics are reported. The applicability, of various empirical kinetic models to the description of the data is assessed, and an attempt is made at the modelling of the rate data in terms of established theories about the diffusion of ions through films of stagnant liquid and through spherical beads of resin.

Jan 1, 1980

By K. R. Noble

The planned extraction of the No. 1 shaft pillar at Blyvooruitzicht Gold Mine highlighted a number of potential problems. In spite of the relative shallowness, careful thought had to be given to stope phasing owing to the detrimental effect of the anticipated geology and the fact that uninterrupted hoisting was necessary. Extensive use was made of computer modellig to design the stope phasing, determine the influence of regional support and to predict the direction and magnitude of displacements in the shaft. The paper describes the success of this design approach, and measured displacements in the stoping horizon and shaft barrel are compared to those obtained from the original computer model

Jan 1, 1987

By W. J. C. Pothas

This paper describes the state of the art in backfilling techniques used on East Driefontein Gold Mine. Areas covered are the preparation plant, the distribution plant, the pipeline network and finally placement techniques. The in-situ performance of placed backfill has been assessed by the Chamber of Mines Research Organization, and results to date will be shared. Details of the backfill expansion programme that will enable this facility to be made available to all working places are included. Benefits obtained by the introduction of backfilling are described, together with certain management aspects to be considered in the control of quality and quantity of support supplied via a pipeline.

Jan 1, 1988

By C. Birch

"A mineral resource royalty is payment to the holder of mineral rights for the utilization of the mineral resource. In South Africa, this payment is made to the State as holder of the mineral rights (The Mineral and Petroleum Resources Royalty Act of 2008). The principle purpose of this research paper is to identify if the State is benefitting from the mineral resource royalty by considering its impact on seven individual Witwatersrand gold mines.For this study, a simple financial optimiser model was created in Microsoft Excel that links the ore flow, block listing and the cash flow (excluding or including the cost of the mineral resource royalty). Mixed integer linear programing (the Excel Solver function) is utilised to optimise either profit or NPV (at 9% and 12%) by adjusting the cut-off grade.The impact on each of the seven mines mine was different but overall R7.9 billion is estimated to be paid in mineral resource royalty over their expected remaining lives. Due to the cost of the mineral resource royalty and increasing the cut-off grades, the total revenue decreases by R10 billion. A significant portion of this lost revenue would have been paid to the State in the forms of other taxation including company income tax which decreases by R2.8 billion. It is recommended that an industry wide investigation be conducted to determine if the resource royalty is adding to the State’s revenue, or destroying value including premature job losses. IntroductionTaxation of mining companies has become a very topical subject in the context of the postapartheid South African economy. There have been increasing calls for equitable re-distribution of mineral asset wealth for the benefit of all South African citizens and not just to an elite few. As part of the Mineral and Petroleum Resources Development Act (MRDPA) of 2002, the Mineral and Petroleum Resources Royalty Act of 2008 was introduced and came into effect in 2010 (South African Revenue Services, 2008). A mineral royalty is payment to the holder of mineral rights for the utilization of the mineral resource. In the case where the holder of the mineral right is the State, then this payment is made to the State (Cawood, 1999). Studies on the potential impact of the mineral resource royalty on the minerals industry have been conducted during the formulation of the Act and subesquently. These include Cawood and Macfarlane (2003), who suggested a cap of no more than 3% (Cawood and Macfarlane, 2003), as well as Cawood (2011), who predicted rising cut-off grades and thus reducing mineral reserves. In 2013, Grobler completed a Masters in the Faculty of Economic and Management Sciences at the University of Pretoria and concluded that the impact of the mineral resource royalty on the economy is positive. She stated that the royalty has caused operating expenses to increase, but this does not appear to be significant. Furthermore, she stated that the royalty has not affected the way the mining industry operates (Grobler, 2014)."

Jan 1, 2016