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By N. S. Dalal, Xianglin Shi

"Electron spin resonance (ESR) measurements provide direct evidence for the involvement of Cr(V) in the reduction of Cr(VI)· by NAD(P)H. Addition of hydrogen peroxide (H2 O 2) to NAD(P)H-Cr(VI) reaction mixtures suppresses the Cr(V) signal and generates hydroxyl (·OH) radicals (as detected via spin trapping), suggesting that Cr(V) reacts with H2O 2 to generate the ·OH radicals. Reaction between H2O 2 and a Cr(V)·glutathione complex, and between H2O 2 and several Cr(V)-carboxylato complexes also produces ·OH radicals. These results suggest that Cr(V) complexes catalyze the generation of ·OH radicals from H2O 2, and that ·OH radicals might play a significant role in the mechanism of Cr(VI) cytotoxicity. KEY WORDS: ESR. spin trapping, Cr(VI) reduction, Cr(V), hydrogen peroxide, free radicals.INTRODUCTIONThis communication reports an ESR spin trapping detection of hydroxyl ( OH) radicals.in reactions between some Cr(V) complexes containing biologically important ligands and hydrogen peroxide (H2O 2 ). This work was undertaken because while the reduction of Cr(VI) to lower oxidation states has been suggested as a key step in the mechanism of Cr(VI) toxicity, the reaction· mechanism is not yet clear. 1 Mutagencity has been well documented for Cr(VI) via various bacterial assays, while Cr(III) has been shown not to be mutagenic.2 • 3 Since it has been reported that compounds containing Cr(VI) do not react with isolated DNA,4 the reduction of Cr(VI) by other cellular constituents has been thought to be important in the mechanism of Cr(VI) induced DNA alteration.1·4 • 5 For cellular systems earlier studies include those on the reduction of C~(VI) by microsomes,6-8 rat liver DT-diaphorase,9 and aldehyde oxidase. 10 Regarding the reduction mechanism, Jennette used ESR spectroscopy to show that a long-lived Cr(V) complex is formed as an intermediate in the microsomal reduction of Cr(VI) in the presence of NADPH.8 She postulated that Cr(V) is the ""ultimate"" carcinogenic form of chromium compounds. This conclusion has led to many further investigations of the formation of Cr(V) in the reduction of Cr(VI) under biologically relevant conditions.11 - 19 More recently, however, it has been suggested that oxygen-derived radicals generated during the Cr(VI) reduction are the species responsible for the DNA alteration.20.2• To the best of our knowledge, however, no information is available on the generation of such radicals in the reduction of Cr(VI) under biologically relevant conditions, except some preliminary results on the glutathionyl (GS·) radical formation in the reduction of Cr(VI) by glutathione (GSH). 11 - 19 We, therefore, undertook a systematic investigation of the reaction of Cr(VI) with NAD(P)H, GSH, ix-hydroxycarboxylic acids, and H2O 2 • NADPH was chosen as a model reductant because of its ubiquitous existence inside the cells, its critical role in the enzymatic Cr(VI) reduction,1·6-9 its representation of important cellular Cr(VI) reductants, and its ability to reduce other metal ions.22 GSH was chosen as another model Cr(VI) reductant because GSH also exists inside cells, it represents another important category of cellular Cr(VI) reductants, the thiols, and it also plays an important role in the Cr(VI) toxicity .1• 1 ""- 19.i3.i4 For further clarification, we also studied the reaction of Cr(VI) with several '1'.-hydroxycarboxylic acids in the presence of H2O 2 since these acids are definitively known to reduce Cr(VJ) to form stable, isolable Cr(V).25 .2 6 The results obtained indicate that Cr(V) complexes, produced in the reduction of Cr(VJ) by cellular reductants, react with H2 O 2 to generate ·OH radicals, which might be the initiators of primary events in Cr(VI) carcinogenicity."

Jan 1, 1990

By N. S. Dalal, Xianglin Shi

"Electron spin resonance (ESR) spin trapping experiments have been carried out to investigate the mechanism of sulfite oxidation em¬ploying 5,5-dimethyl-l-pyrroline-1-oxide (DMPO) as a spin trap. The results show that sulfite autoxidation, catalyzed by Mn(II), involves not only the SO-3 radicals but also the •OH radicals. An addition of H2 02 to the sulfite aqueous medium significantly increases the •OH radical formation. This result provides new clues to the chemical mechanism of the sulfite oxidation and the sulfite toxicity.INTRODUCTIONStudies of the oxidation of the sulfite (SO 2-/3) ions under various conditions are of high current interest because excessive exposure to sulfite is toxic and the origin of this toxicity seems to involve sulfite oxidative pathways [1]. An important fact is that human exposure to sulfite is on the increase [1,2]. Some of the increase in the sulfite exposure is linked to the fact that SO2 is a major air pollutant [2] and in aqueous media SO2 exists in equilibrium with SO2-/3. In addition, beverages and foods are common sources of sulfite intake. For example, sulfite is used extensively in the wine industry as an inhibitor of yeasts and bacteria and is present in finished wines in concentrations up to 6 mM [1]. Sulfite is also often added to dehydrated fruits, vegetables and soups, as well as fruit juices and beer [1,3,4]. Because of these, the mean daily intake of sulfite from diet (in the United States) has been estimated to be between 0.0014 and 0.14 mM/kg body weight [1]. At such high levels, sulfite exposure can have toxic effects, such as the induction of an acute asthmatic state [5,6]. Sulfite also appears to have adverse genetic effects [7] and can act as a mutagen or comutagen [8] and a cocarcinogen [5,7-9]."

Jan 1, 1990

"Le présent article porte sur la diminution des rejets de concentrateurs produits durant l’exploitation et le traitement des minerais métalliques.Le minerai dilué envoyé au traitement a, très souvent, un certain pourcentage du stérile qui affecte directement la rentabilité des opérations souterraines et amplifie l’impact négatif sur l’environnement. Les essais de la séparation du stérile et du minerai effectués en milieu dense sur quelques types de la minéralisation d’or, ont démontré les deux possibilités qu’offre cette technique:• Dans le cas d’un minerai riche, il a été possible de séparer la part importante du toutvenant (minerai dilué contenant le minerai et le stérile) provenant de la dilution, tout en ayant un taux de récupération élevé (supérieur à 96%).• Dans le cas d’un minerai ayant une teneur sub-économique à cause d’une dilution importante, il est possible de produire un concentré ayant une teneur économique à l’entrée de l’usine de traitement, en éliminant une partie du tout-venant.En plus la séparation du stérile peut accroître, en outre, la rentabilité de l’exploitation minière, car le fait d’éliminer la partie de stérile le plus tôt possible diminue certains coûts (transport, traitement et autres). On conclue que la pré-concentration du minerai (séparation du stérile et du minerai) est probablement une seule solution actuellement étudiée qui diminue l’impact environnemental de la mine, sans avoir des conséquences négatives sur la rentabilité de l’exploitation souterraine."

Jan 1, 1997

By F. Chen, L. J. Gaydos, L. M. Demers, D. C. Kuhn, S. C. Sun

"In this report, we demonstrate that NF-KB, a ubiquitous transcription factor, plays an essential role in silica-induced inflammatory mediator production in the mouse macrophage cell line RAW 264.7. Compared to the effect of lipopolysaccharide (LPS), silica mediated a stronger activation of NF-KB p50/p50 homodimer at early phase of poststimulation. Furthermore, activation of NF-xB by silica and LPS appears to be mediated by different signal transduction pathways. Both silica and LPS increased mRNA expression in these cells for cyclooxygenase II, inducible nitric oxide synthase, tumor necrosis factor-a and interleukin- I a. This expression was attenuated along with the inhibition of NF-KB activation. It is well documented that exposure of alveolar macrophages to silica can initiate excessive production of inflammatory mediators and cytokines from several early response genes (1-3). At the DNA level, a common structural characteristic of these genes is the presence of one to five NF-lCB binding sequences (KB) in the 5'-flanking region (4-6). In resting cells, NF-KB is retained in the cytoplasm in an inactive form by binding to inhibitory protein known as hcBcx, hcB~. p 105 (precursor of p50) and p 100 (precursor of p52) (7-9). Upon cellular stimulation, these inhibitory proteins are proteolytically degraded or processed by certain proteases, which allows the liberated NF-KB to translocate into the nucleus as an activated form to initiate or regulate early response gene transcription by binding to its consensus element (GGGRNNYYCC)(7).In this report, we demonstrate that silica can efficiently induce NF-lCB activation in RAW 264.7 cells, and that silica displays different characteristic from LPS in the activation of NF-KB, both with respect to NF-KB subtype composition and the signal transduction pathway that leads to the activation of NF-KB. In addition, abrogation of NF-KB activation by inhibiting the protease can dramatically reduce the mRNA expression of cyclooxygenase II, inducible nitric oxide synthase, tumor necrosis factor-ex (TNF-o.) and interleukin-lex (IL-lex). These findings strongly suggest that NF-KB plays an essential role in silica-induced inflammatory mediator production in the monocyte/ macrophage cells."

Dec 1, 1996

By Mariana Peixoto

Muitos componentes de ferro fundido ficam expostos a altas temperaturas quando em serviço, podendo ocorrer a decomposição da perlita através da difusão do carbono da cementita para as lamelas de grafita, resultando em alteração microestrutural e degradação das propriedades mecânicas. A influência que a temperatura e o tempo de exposição têm sobre a microestrutura de um ferro fundido cinzento foi avaliado em amostras de quatro ferros fundidos de mesma base, com diferentes percentuais de cromo e molibdênio. Ensaios de banho de sal a uma temperatura de 500ºC foram realizados em corpos de prova com diâmetro de 10 mm. Os ensaios foram realizados com tempos de exposição a esta temperatura, após homogeneização térmica do material, de 0, 1, 2 e 4 horas. As análises metalográficas evidenciam a ocorrência da decomposição da perlita. Adicionalmente foram realizados ensaios de microdureza, a qual se mostrou sensível às alterações microestruturais geradas pela temperatura elevada. O ferro fundido com maior percentual de cromo e molibdênio apresentou melhor estabilidade da microestrutura para as condições ensaiadas.

Aug 17, 2017

By Belmira Benedita de Lima

Estudos no sistema Nb-B mostram a fase Nb5B6 com formação peritética a partir do líquido, porém sua estabilidade abaixo de 2.000°C não é comprovada experimentalmente. Há também dúvidas sobre a ocorrência da fase Nb2B3 neste binário. Este trabalho tem como objetivo o estudo da estabilidade das fases Nb5B6 e Nb2B3 nas temperaturas de 1.400°C e 1.800°C. Amostras com composições nas estequiometrias Nb5B6 e Nb2B3 foram produzidas através de fusão a arco assim como confeccionadas a partir de misturas de pós de B e NbB. Pastilhas com composição Nb5B6 foram produzidas com e sem adição de semente da fase Nb5B6. Os tratamentos térmicos em 1.400°C foram realizados por até 10h enquanto aqueles em 1800°C por até 1h, todos em atmosfera estática de argônio. As microestruturas das amostras, tanto no estado bruto de fusão como após tratamento térmico, foram caracterizadas por difração de raios X (XRD). Os resultados confirmam a formação fase Nb5B6 a partir do líquido e nas amostras produzidas via metalurgia do pó. A fase Nb2B3 não é observada nas amostras no estado bruto de fusão e nas amostras produzidas via metalurgia do pó tratadas termicamente a 1.800°C, porém, esta fase se estabiliza nas amostras produzidas via metalurgia do pó tratadas a 1.400°C, indicando sua estabilidade com formação peritetóide a partir das fases Nb3B4 e NbB2, abaixo de 1.800°C.

Aug 8, 2018

By Samuel Vasconcellos

Em plantas de separação do tipo PSA ocorrem oscilações na vazão de ar intrínsecas a este processo, devido à repressurização dos vasos pré-purificadores ser feita em intervalos muito curtos. Por meio da instalação de um buffer tank foi possível tornar a coluna de destilação mais estável, aumentando a produção de líquidos, reduzindo a demanda de energia e otimizando a pré-purificação.

Jul 31, 2018

By Rafael Lioji Kogake

O Alto Forno n° 2 é responsável por cerca de 40% da produção de gusa na CSN. Uma das principais utilidades responsável pela transformação do minério de ferro em gusa é o ar soprado que é fornecido por dois turbo sopradores da Central Termoelétrica n°2. Para que ocorra o processo de transformação do minério é necessário que o ar soprado seja aquecido. Isto é feito através dos regeneradores, os quais aquecem o ar para cerca de 1.300°C. Como cada regenerador tem um tempo de campanha, é necessário fazer a troca do mesmo a cada 1 hora. Nesse momento de mudança de regenerador, uma parte do ar soprado é desviado para o regenerador que está entrando em operação e ainda está vazio. Com isso, há uma perda pontual de produção indesejada, além de causar instabilidade no processo. A solução encontrada para reduzir este problema foi aumentar a vazão de sopro durante o período de troca de regeneradores, garantindo assim uma maior produção e melhor estabilidade do Alto Forno 2. Este trabalho apresenta o estudo do problema em questão, a metodologia utilizada para a sua implementação e os resultados alcançados.

Jul 31, 2018

By H. Meseck

Dynamic pile test methods to establish the bearing capacity of driven piles were developed in the USA more than 20 years ago. In the Federal Republic of Germany, the first dynamic pile tests were carried out at the end of the 70's. Today dynamic pile tests are successfully used to establish the integrity and bearing capacity of driven and bored piles. The Institute of Foundation Engineering and Soil Mechanics at the Technical University of Braunschweig has developed its own method of measuring and evaluation for the execution of dynamic pile tests. The principles of the dynamic pile tests, the measuring and evaluation plant as well as the experience gained with it in the examination of cast-in-place piles are presented in this contribution.

Jan 1, 2010

The paper presents a brief history of endeavours to start a mining education programme which began in the days when Papua New Guinea's first large mine, at Panguna (Bougainville), was coming into production. The status of the Public Investment Programme in Mining Engineering and the facilities being created for the education and training of Papua New Guinean citizens in mining and mineral processing are also described. Future expansion plans are also detailed including those for the commencement of petroleum engineering and geological engineering which would include courses in mining geology, exploration geology, engineering geology and petroleum geology. The paper also looks at the manpower training requirements in the lower levels of mining industry such as pit foreman, blasting foreman and other similar positions. It stresses the need to start mining technical training programs at pre- employment level and at certificate level in a technical college, possibly Lae Technical Colleqe.

Jan 1, 1991

By A. S. Macfarlane

Mineral resource management (MRM) practice has developed in South Africa over the course of the last ten years, with the purpose of integrating previously isolated technical functions into a value chain aligned, process organization, responsible for mine planning and optimization. The implementation of MRM within various companies has met with varying degrees of success, often resulting in incremental improvements in the planning process and, conversely, often becoming the scapegoat for poor delivery on plans and projects. The reason for this has been, amongst others, a lack of a suitable metric to define the success rate of MRM in the business at hand, in terms of its contribution to the bottom line. This paper is the result of extensive research by the author into this subject, which has resulted in the conclusion that economic value added is an appropriate measure that will lead to real optimization and value creation in mining companies, if applied within a new, holistic model

Jan 1, 2006

By M. du Plessis, J. P. Gouvea

Mesh based areal support is commonly applied in South-African deep-level gold mines. It forms part of an integrated support system that can cater for both rockfall and rockburst incidents. The application has been successfully applied over many years. Operations have different geotechnical conditions and practical considerations, which has led to the development of various types of mesh and integrated mesh-based support systems (i.e. meshing and lacing versus welded or chain-link mesh sheets). Typically rolls or sheets of mesh is pinned with rockbolts to the surface of an exposed excavation. Applications vary from hangingwall coverage in a conventional stope gully to complete excavation coverage in footwall drives of conventional mines or on-reef drives in massive mechanised mines. It is however critical to understand the behaviour of the rockmass and apply suitable support systems.

Apr 26, 2022

By Paul J. O'brien, George N. Neary

"The base metal mine at Buchans, Newfoundland, has been producing since 1928. For many years, mill tailings were disposed of by dumping into a nearby natural watercourse via which they were transported to Red Indian Lake and deposited. In 1965, environmental concerns prompted the establishment of settling ponds near the mine site. Effluents fed to these ponds included slimes washed from mine backfill sand and waste water pumped from underground as well as mill tailings. Dusting around the perimeter of the ponds was first observed around 1970and within a couple ofyears reached serious proportions. A program to alleviate the condition by developing a vegetative cover over the tailings was commenced in 1974. The work was successfully carried out and demonstrated that the large area of waste could sustain a permanent cover of grasses.This paper outlines the experimental work done at Buchans as well as the procedures followed and the problems encountered in carrying out full-scale revegetation."

Jan 1, 1981

This United States Bureau of Mines study is based on a review of U.S. mine fire accidents that occurred from 1970 through 1989. Information on these accidents was obtained through investigative reports written by Mine Safety and Health Administration personnel. For this study, 260 mine fire accident reports were examined. A previous Bureau research effort established that fires causing fatalities were more likely to occur in haulage entries than at any other underground location. This study has found that the most prolific source of haulage entry fires was the inadvertent grounding of trolley wires. The largest segment (15 out of 40 trolley wire fires) resulted from not maintaining adequate clearance between the trolley wire and the vehicle. Several novel fire prevention and control ideas have evolved in response to frequently occurring fire-related problems. These included; discriminating power isolation devices, wire cutting devices, more accessible fire extinguishers, vehicle overcurrent protection, and vehicle fire suppression.

Jan 1, 1994

By John E. Newby

The Brightwater Conveyance System consists of four tunnel segments in three tunnel con-tracts, comprising over 21,760 m (71,400 ft) of pressurized face tunneling in complex glacial and non-glacial soft ground conditions with a large proportion 60 m (197 ft) or more below the ground surface with up to 7 bars groundwater head. This resulted in unique technical challenges for establishing geotechnical baseline values. The process used to develop these baseline values and specifications with regard to the level of risk that the owner, King County, was willing to accept is described in this paper.

Jan 1, 2008

By W Donovan

Concern exists about the potential release of metals from the proposed mining operation at Martha Hill to the Ohinemuri River. Speculation on possible impacts is fuelled by the dearth of published data on existing metal levels not only for this river system but for streams throughout the Coromandel. At first sight this lack of data is surprising given the apparent interest in this subject and the fact that future mining activity in this region has been a possibility since at least 1979. That such a situation has arisen is not altogether unexpected given the difficulties faced by various organisations, including the mining industry, in determining metal levels which are generally acknowledged to be low. This paper presents data for a number of stations in the vicinity of the proposed operation; it explains the analytical procedures which were adopted and the rationale for them and relates the information which has been obtained to water quality criteria.

Jan 1, 1986

By Tony Lipiec, Chris Fleming, Larry Urbanoski

In 2009, the Canadian Mineral Processors (CMP) became aware that Canadian securities regulators were amending the contents of National Instrument 43-101. NI 43-101 is a set of regulations which establish how ore resources and reserves are presented to the investing public. The documents produced under NI 43-101 are central to the ability of many companies to raise financing for their projects. With the increase of metallurgical complexity, and decrease of head grades encountered in new deposits, the role of the Qualified Person (QP) in determining process performance has become increasingly critical in determining the classification category of resources and reserves. Given the challenges confronted by those involved in defining the concentration and extraction of minerals and metals, there is a need to provide support to these QPs. To address these concerns, the CMP established a sub-committee in 2010 to create a set of guideline documents to assist the QP involved in process matters as to what should be included at the various levels of study supporting the establishment of resources and reserves in NI 43- 101. The results of the sub-committee work are presented and the considerations in the writing of the documents are discussed.

Jan 1, 2011

By R Shrimali, P Rajmeny, L Shekhawat, A Joshi

Rampura Agucha open pit mine has successfully been excavated to a depth of 320 m, incorporating multistage working. The key to success is the implementation of presplitting as control blast measures at every stage of mining, including intermediate cut backs, in addition to the final wall. The major challenges encountered in establishing presplitting in the hang wall as compared to the footwall of the mine are:reversely dipping foliation, ie dipping into the hang wall itselfstriking obliquely at an angle of 20–30° with regards to the general strike of the pit wallthe presence of numerous geological planes of weaknesses like major faults, slips, etc.Control blast parameters like hole inclination, spacing and stand-off with buffer row were chosen initially from the literature survey and were subsequently fine-tuned by field trials to the mine geo-mining conditions of the hang wall. Electronic initiation used for trim blasts along with double presplitting in fault-affected zones helped in getting better presplit performance and resultant stability of the hang wall.CITATION:Rajmeny, P, Shrimali, R, Shekhawat, L and Joshi, A, 2015. Establishing the design parameters of a control blast for long-term stability of the hang wall at Rampura Agucha Mine, in Proceedings 11th International Symposium on Rock Fragmentation by Blasting, pp 437–446 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Aug 24, 2015

By S. Rupprecht

Project evaluations of mineral deposits are necessary for mineral rights, owners and investors alike. A feasibility study provides a definitive technical, environmental and commercial base and is the key element leading to a decision to invest or not to invest. For example, the study may be used to justify further exploration and development expenditure or to provide a basis for a major underwriting to raise the required capital. There are three distinct phases in the development of a project and the type of study will differ depending on the quality of information available or the level of decision to be made. This paper looks at these three phases in the development of a mineral project and the type of study required; namely, a scoping study, prefeasibility, and a full feasibility study. Keywords: scoping studies, feasibility studies, mining projects.

Jan 1, 2004

By B. Jago

From the perspective of metallurgical processing, gold ores can be classified into freemilling and refractory ores. Their extractive metallurgy is largely driven by mineralogical factors such as gold particle size, association with other minerals, coatings and rimmings, presence of cyanicides, oxygen consumers and preg-robbers, presence of refractory gold minerals, and invisible gold in sulphide and sulpharsenide minerals. Gold process mineralogy helps address issues and problems related to gold ore processing. It is widely used as a predictive and trouble-shooting tool in gold ore processing, and provides useful information on process selection, flowsheet development, recovery improvement, and reagent consumption optimization. By combining classic mineralogical techniques, modern instrumental analysis, and diagnostic metallurgy, the mineralogist is able to balance the various types of gold occurrence in an ore.

Jan 1, 2006