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By D. Eugene Rannels, Sarah E. Dunsmore

"Dunsmore, Sarah E., and D. Eugene Rannels. Extracellular matrix biology in the lung. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14): L3-L27, 1996.-The lung and other organs are comprised of both cellular and extracellular compartments. Interaction of these components modulates physiological function at the organ, cellular, and subcellular levels. Extracellular components in the gas-exchange region of the lung include both noncellular interstitium and basement membranes. Connective tissue elements of the interstitium in part determine ventilatory function by contributions to tissue compliance and to resistance of the diffusion barrier. The basement membrane underlies cells of both the alveolar epithelium and the capillary endothelium; basement membrane components exert biological effects on adjacent cells through receptormediated interactions. This review emphasizes current knowledge concerning the composition and biological activity of extracellular matrix in the alveolar region of the lung. Matrix synthesis and turnover are also considered. Directions for future research are suggested in the context of current knowledge of the lung and other model systems. EXTRACELLULAR MATRIXEXTRACELLULAR MATRIX is a general term that encompasses components of the basement membrane and interstitial connective tissue. The extracellular matrix has many functions. It provides structural support, compartmentalizes tissues by separating epithelium or endothelium from interstitium, and serves as a physical barrier. Both in vivo and in vitro studies show that extracellular matrices also affect cell shape and function. The matrix elicits a variety of cellular responses, including adhesion and spreading, changes in cytoskeletal organization and differentiation, formation of focal contacts and stress fibers, stimulation of proliferation and migration, induction of polarity and gene expression, alterations in metastatic activity, and outgrowth of cell processes (for review see Refs. 387, 462). Cellmatrix interactions play roles in embryonic development and organogenesis (for review see Refs. 1, 91), in wound healing (for review see Refs. 145, 327), iri metastasis (for review see Refs. 430, 431), and in angiogenesis (for review see Refs. 185, 186). The extracellular matrix is the subject of a large volume of literature. In 1994, over 1,000 articles contained extracellular matrix in the title or abstract. After a brief discussion of key aspects of extracellular matrix biology, this review will focus on the extracellular matrix of the lung."

Jan 1, 1998

By John P. Coughlin

The Bureau of fines has tested a portable microseismic processor recorder at the Galena Mine, Wallace, ID, both in an environmentally controlled enclosure and, with minimal protection, in a working area of the mine. In both trials the device demonstrated effective and reliable data acquisition capabilities.

Jan 1, 1985

By May J. R

Exploration, including research, has fuelled the enormous expansion of the Australian mineral industry in the last three decades. Analysis of success and failure in exploration and research has therefore potentially powerful lessons and messages which may be used to influence the future shape and direction of the mineral industry. Research has been an integral part of organised corporate mineral exploration since its beginnings in Australia in the 1930s. In corporations, the activity generally called project generation or new project development is the main expression of exploration research but mostly it goes unidentified and poorly documented except perhaps when a successful discovery is made and reported on. The competitive nature of exploration means that extended and detailed analysis of corporate exploration research across the industry is impossible to achieve.

Jan 1, 1992

By D. Lunt

Telfer bulk concentrates typically contain 8% chalcopyrite, 8% chalcocite, 45% pyrite and 80-120 g/t gold. Although very high copper and gold recoveries can be obtained by subjecting the concentrate to a "conventional" high temperature pressure oxidation step followed by copper recovery by solvent extraction and electrowinning, and cyanidation of the leach residue for gold recovery, the cost of lime required for neutralisation and power for oxygen generation was such that the process was uneconomic in terms of operating costs. The challenge therefore was to develop an alternative flowsheet that maximised copper and gold recovery in which the reagent costs were commercially attractive. An additional objective was to reduce the capital cost so that the overall NPV and IRR values would enhance the economic viability of the total project. Following a series of batch and locked cycle testwork programs, supported by Metsim modelling, it was established that the same high levels of overall copper and gold recoveries can be obtained by use of a novel two-stage split leaching circuit in which the chalcocite component is leached in a low temperature (90-110°C) circuit with the chalcopyrite component treated in a high temperature (220-250°C) circuit. This split circuit has a number of advantages, including minimising the required capacity of the high temperature autoclave, as well as reducing the overall lime consumption and simplifying the total process water balance. The paper outlines the basis for the development of the flowsheet and discusses the integration of the leaching stages into the overall circuit.

Jan 1, 2004

By A. Koster, V. Maurel, S. Dezecot, Szmytka. F.

The aim of this work is to clarify the role of microstructure heterogeneity in the initiation and growth of cracks in a lost foam cast A319 for low cycle fatigue (LCF) loading condition. Because 2D analysis fail to establish the scenario of damage events, this study is based on 3D in situ analysis using synchrotron X-ray tomography during LCF test performed at 200°C. If X-ray tomography is now an established technique to study damage development in 3D, its application for relatively high temperature cyclic tests has never been done so far. Initial 3D observations of damage show that the cracks that lead to fracture initiate near large pores and propagate into the hard particles 3D network of the eutectic regions.

Jan 1, 2015

By Simon Chiartano

A global reflection on the design of blast furnace main runner was investigated in this paper. TRB Company used its skills and expertise to understand what the best option for this sensitive component is, including some innovative tools: intelligent block design for safety lining, thermal & thermomechanical numerical simulation, immersive measurement by thermocouples, IR thermal camera, 3D laser scanner.

Oct 1, 2019

By Ernest F. Giovannitti

A couple of years ago, one of the major television networks produced a series on the environment. One episode in the series dealt with the nation's solid waste problem and some of the research being done to solve it. It was interesting to listen to one researcher who was attempting to develop a glass that when broken would dissolve in water. It was said that using this glass would eliminate over 100 million tons of solid wastes each year. At first glance, it would appear that this research-effort would make a significant contribution to environmental pollution control; however, if one pauses to consider the water, he can see that this solution to the solid waste problem may well contribute to a water pollution problem. The dissolved material must either end up in our surface streams or be removed in waste treatment systems. Either alternative may have a more adverse effect on the environment than the original problem. With today's emphasis on the environment, it is important that the effects of our activities be studied in depth. Then, by properly planning the activity, the adverse effects can be minimized. The coal mining industry 100 years ago was in the same boat, as our glass maker, is today. Unfortunately, it too failed to consider all the effects of its activities and as a result, in Pennsylvania, there are over 5000 miles of streams adversely affected by coal mine drainage. The situation is improving, however, because mine operators are beginning to recognize and accept the methods for controlling coal mine drainage. The purpose of this paper is to discuss the measures for the control of coal mine drainage and to set forth the factors that affect these controls.

Jan 1, 1972

By J. R. Andrews, R. P. Young, J. M. Reyes-Montes

"Microseismic monitoring provides insight into the location and extent of rock-mass fracturing induced by cave mining, enabling interpretation of the cave profile and validation of predictive numerical models. Source location uncertainties can lead to misinterpretation of the inferred characteristics of the fracture network. One principal source of uncertainty is the velocity model used to invert the location algorithm. Large-scale 3D numerical models of modulus changes across a caved mass can represent such complexities in the location algorithms, allowing more accurate interpretation of the microseismic activity. A Northparkes mine case study applies this advanced approach to microseismic data interpretation.RÉSUMÉ Le suivi microsismique fournit des renseignements sur la localisation et l’étendue des fractures de la masse rocheuse induites par l’exploitation par blocs foudroyés; cela permet d’interpréter le profil de la chambre foudroyée et de valider les modèles prédictifs numériques. Les incertitudes quant à la localisation de la source peuvent conduire à des mésinterprétations des caractéristiques inférés du réseau de fractures. Une des principales sources d’incertitudes est le modèle de vitesse utilisé pour inverser l’algorithme de localisation. Des modèles numériques tridimensionnels à grande échelle des changements du module d’élasticité à travers une masse foudroyée peuvent représenter de telles complexités dans les algorithmes de localisation, permettant ainsi une interprétation plus juste de l’activité microsismique. Une étude de cas à la mine Northparkes applique cette approche avancée à l’interprétation des données de microsismicité."

Jan 1, 2016

By B. Listerud, G. Zhan, M. A. Jones

Barrick Goldstrike Mines Inc. (BGMI) operates the Betze-Post openpit and the Meikle and Rodeo underground mines. Because the majority of the orebody is located below the water table, mining at BGMI requires a significant dewatering program. BGMI has a comprehensive dewatering and water management system that experienced a peak dewatering rate of 4,400 L/s in the mid 1990s. Changes to the hydrologic/hydrogeologic system caused by the mine dewatering have been monitored by an extensive network of groundwater monitoring wells and surface water monitoring stations, which cover about 1,550 km2. In addition to the monitoring program, a new tool, called Interferometric Synthetic Aperture Radar (InSAR), has also been used to enhance the evaluation of changes. Finally, a groundwater flow model has been developed that successfully simulates and predicts aquifer responses in the mine area and region. The well-calibrated flow model has served as a reliable tool to develop dewatering and mining plans, and project post-closure hydrologic conditions in the region. This paper introduces the BGMI dewatering and water management system and the means used by BGMI to evaluate and anticipate hydrologic responses in the region. The water management and analysis system has been and continues to be an integral part of managing ongoing operations, planning and pricing out future activities and evaluating the long-term effects of mine water handling.

Jan 1, 2011

By W. J. van Wyk, W. I. Mahne, G. Priest, C. du Toit, W. A. Liebenberg

Prior to the Coalbrook disaster in 1960, bord-and-pillar mining of the number two seam in the Witbank coalfields often resulted in small pillars with low factors of safety. At the Goedehoop Colliery, number two seam pillar stability is also affected by top and bottom coaling, while at Greenside Colliery, stability was further reduced by additional loading from a surface mineral residue deposit. This compromised the stability of the number two seam workings, impacting the safe mining of the overlying number four seam reserves. To extend the life of mine of both operations, an alternative risk management approach using designated enhanced monitoring districts was implemented to safely mine the number four seam reserves. This paper presents the use of geophone arrays to monitor micro-fracturing in number two seam pillars and the interburden between number two seam and number four seam, thereby enabling early detection of potential instability during overmining of the number two seam. Risk was assessed using fault and event tree analyses to determine acceptable failure probabilities. Automated seismic data processing distinguished micro-fracturing from noise, supported by extensive evacuation procedures for effective risk management. This approach facilitated the safe extraction of 4.70 Mt of number four seam coal. The study quantifies the efficacy of geophone monitoring in optimising coal recovery over low factors of safety pillars and assesses the application of Van der Merwe’s (2019) time-based formulae for pillar stability analysis for this project.

May 8, 2026

By Dirk Bleazard

Barrick Goldstrike Mines is improving the reliability of mining and processing equipment through the use of failure analysis and condition monitoring activities. Program results include an increase in equipment capacity and an overall reduction in operating costs. Identifying equipment failure modes and developing associated capital asset management practices can minimize failure consequences. Successful programs have included alterations to management practices, equipment modifications, and/or the implementation of condition monitoring programs. By controlling or minimizing the effects of incipient equipment failures, corrective actions can be taken earlier in the failure cycle. This results in an associated reduction to repair costs and equipment down time. Mining companies invest in their capital assets to provide the capacity necessary to meet operational needs. Over time, functional failures occur that reduce this productive capacity. Diagnostic technologies now exist that allow the condition of equipment to be monitored. Early response to this information minimizes the effects of functional failures and restores equipment re- liability. Reliability is a performance indicator of overall equipment condition. It is most often expressed in terms of mean time between failures. When the established objectives of a capital asset management program include the maximization of this failure interval, trailing indicators, such as availability and operating cost improve. The probability of equipment failure is influenced by engineering design and operating conditions. The performance level resulting from this operating environment is expressed as "inherent reliability." Without maintenance intervention, equipment will ultimately fail to perform its intended function and become less reliable. Therefore, maintenance must be managed as the supplier of reliable operational capacity. Maintenance can only supply equipment performance that approaches the level of inherent reliability. Actually achieving inherent reliability requires that all maintenance decisions are made at the economically optimal time. Enhancing performance levels beyond inherent reliability can only be achieved by altering operating conditions or practices or through physical equipment modifications. An evolution in maintenance management philosophy has been under way since the beginning of the industrial revolution. As equipment has become more sophisticated, so have maintenance practices. At the beginning of the industrial age, equipment tended to be over designed and slow moving. The first maintenance philosophy was one of reactive maintenance. Maintenance intervals were dictated by the operational status of the equipment. As a result, production interruptions were common and capacity needs were met through an investment in redundant capital assets.

Jan 1, 1998

By M. Louarrat, G. Enaime, A. Yaacoubi, A. Baçaoui, J. Blin

"The purpose of this study is to prepare a new activated carbon from olive stones for use in gold recovery by carbon-in-leach (CIL) and carbon-inpulp (CIP). The preparation method chosen was physical activation using steam. The effect of four process parameters: the residence time for carbonization, the activation temperature, the residence time for activation, and steam flow, were studied by the mean of response surface method (RSM) in order to optimize the yield, iodine index, and attrition characteristics. These two last responses were used as primary indicators of gold recovery capacity and mechanical strength. The results obtained show that optimal activated carbon can be prepared under the following conditions: a carbonization time of 157 minutes, activation at 921°C for 53 minutes, and a water vapour flow of 0.18 mL/min. This optimum carbon has an iodine value greater than 1100 mg/g and an attrition index in the order of 0.74%. These values reflect the quality of the precursor (olive stones) as a raw material for the development of an effective new activated carbon for the gold mining industry. IntroductionActivated carbon is an effective adsorbent widely used in industry due to its high surface area, well-developed reproducible microporous structure, and high degree of surface reactivity and adsorption capacity. World consumption of activated carbon is steadily increasing. It is primarily used in industrial wastewater and gas treatment and also for silver and gold recovery from cyanide solutions (Syna and Valix, 2003; Soleimani and Kaghazchi, 2008; Buah and Williams, 2010; Eddy et al., 2011). However, activated carbon is expensive and it needs to be regenerated after each adsorption cycle. In order to decrease the cost of manufacturing activated carbon, low-cost forest and agricultural wastes are considered promising new materials. In recent years considerable research has been reported on activated carbon from agricultural wastes, such as olive stones (Yavu et al., 2010), acorn shells (Sahin and Saka, 2013), peanut shells (Wu, Guo, and Fu, 2013), grape seeds (Jimenez-Cordero, 2014), coconut shells (Yalcin and Arol, 2002; Gratuito, 2008), palm shells (Sumathi, 2009), cherry stones (Jaramilloa, Gomez-Serrano, and A´lvareza, 2009), macadamia nut shells (Eddy, 2011), apricot stones (Soleimani and Kaghazchi, 2008), and bagass (Syna and Valix, 2003)."

Mar 1, 2019

By Joshua Hoffman, Braden Lusk, David McLane, John Rathbun

The dynamics of explosive detonations are understood; however recreating a real-world, to-scale scenario is costly. The use of a shock-tunnel allows testing to be done on a smaller scale, with the simulated effect of a large explosion. Analyzing explosive waveforms using this method can greatly reduce cost in testing blast-resistant products, such as anti-terrorism devices, mine safety products, and military equipment. The purpose of this project is to better the understanding of how the waveform dynamics of an explosive detonated within a shock-tunnel differ from those in an open-air arena test.

Jan 1, 2011

By Tao Jiang

Germanium is widely used in many fields, and the production of germanium is very important. The effects of initial sulfuric acid concentration, liquid to solid ratio and other parameters on the leaching rate of germanium and zinc from germanium-bearing zinc oxide has been studied. The occurrence and form of germanium and other elements in the leach feed and the leach residue were studied by EPMA, XRD and chemical analyses. The experiments showed that the leaching rate of germanium and zinc was 91% and 88%, respectively under optimal conditions. Wurtzite was the main limiting factor for the leaching rate of zinc while the leaching rate of germanium was limited by insoluble germanium compounds. Furthermore, it was found that some germanium was bound up in galena in the leach residue. These results may be helpful for further improving the leaching rate of germanium in germanium-bearing zinc oxide.

By NATHANIEI HERZ

(Cleveland Meeting, October, 1912.) THE formula very frequently used for computing the economical size of pipe to transmit compressed air is that of D'Arcy, as follows: d5(p1-p2)/w1l D-c w11 Where, D = the volume of compressed air delivered in cubic feet per minute,-at the final pressure. c = an experimental coefficient determined for the various sizes of pipe. d = the diameter of the pipe in inches. 1 = the length of the pipe in feet. P1 = the initial gauge-pressure in pounds per square inch. p2= the final gauge-pressure in pounds per square inch. W1 = the density of the air, or the weight in pounds per cubic foot at the initial pressure, p,. The most common case is that in which the given quantities are: the quantity of air required, the length of the pipe, and the initial pressure. The method of solution is to assume a pressure-loss and to compute the remaining factor, c/d5, thus giving the size of pipe corresponding to the assumed loss of pressure. It is always desirable to try two or more pressure-drops, in order to find the combination that is most satisfactory, since often a small change in the size of pipe will reduce or increase the loss of pressure several pounds. An alternative method is to assume a size of pipe and calculate the corresponding pressure-drop. Each method involves a series of tedious calculations to arrive at the most economical solution, and also requires the use of tables giving the constant, c, the actual diameters corresponding to the nominal pipe-sizes, the density of the air, w1, and often, for convenience, a table giving the

Dec 1, 1912

By D. Swanson

Cold Detonation Physics (CDP) is a patented new field of explosives and the name for the explosive that is produced when non-toxic dry ice (frozen carbon dioxide) is combined with powdered metals such as magnesium and aluminum, which are non-toxic and nitrogen-free. The explosive is detonator-sensitive and detonates according to the rapid reduction of carbon dioxide back to carbon, which produces solids comprised mainly of metal oxides and about 5% carbon. CDP was determined to produce a maximum of 300 liters of carbon dioxide per kilogram (4.81 ft3 /lb) and about 1.5 liters of carbon monoxide per kilogram (0.024 ft3 /lb). Both these figures shift according to metal content where higher metal produces less gases. According to theoretical modelling, the relationship between static pressure and metal content was determined to be an inverse parabolic curve with optimum pressure at 25% to 31% metal, depending on the type/s of metal/s used. Velocity of Detonation (VOD) was determined by measuring light at the wavefront with fiber-optic cable inserted into a series of holes drilled into the side of a 3-inch diameter (76 mm) schedule 40 steel pipe containing the mixture. The highest VOD was observed at 25% magnesium and measured between 2,500 to 4,500 m/s (8202 to 14,764 ft/s) when initiated by a 454-gram (1-pound) booster and an electric detonator. A 25% 50:50 alloy of magnesium and aluminum sample shot at a higher velocity than magnesium, according to how the alloy generated smaller pieces of shrapnel when compared with shrapnel from a magnesium test. CDP, using 25% alloy, was tested for blasting limestone by drilling 3.5-inch holes (89 mm) and inserting a 3-inch x 4-foot cardboard tube (76 mm x 1.22 m) with the mixture, packed to a density of 0.62 g/cm3 . The blast was initiated with an electric detonator, behaved like ANFO with more energy and fractured rock sufficiently across the entire length of the borehole. Seismic analysis determined that CDP produces lower ground vibrations than traditional explosives.

Jan 1, 2024

By J. R. Koehler

The U.S. Bureau of Mines (USBM) ground control research program includes several projects focused on developing design criteria for yielding-pillar-based longwall gate road systems. As part of this program, mining practices at the Sunnyside Mines, Sunnyside Reclamation and Salvage Co., Sunnyside, UT, are being documented to preserve the long history of yield pillar system evolution on the property. Published information describing the specific in-mine performance of the numerous gate road configurations utilized at the Sunnyside Mines is very limited. To overcome this deficit, USBM personnel interviewed 30 longtime mine employees representing nearly 700 years of mining experience at the Sunnyside operations. Mining conditions in 12 specific areas in the Nos. 1, 2, and 3 Mines were discussed in the interviews. Also, broad topics such as general mining practices, safety, and geology were often addressed during the discussions. Comprising the body of this report is an extensive record of the events and conditions experienced while mining the identified areas. In addition, eight significant conclusions were developed that accurately summarize the general opinions of the interviewed personnel regarding mining conditions and practices at Sunnyside.

Jan 1, 1994

By Thomas E. P. Wechsler

The limiting factor for most pyro-metallurgical processes in secondary cop- per melting is the time required to heat and melt the product. American Combustion's proprietary PYRETRON variable £uel/air/oxygen combustion system improves the throughput of existing scrap melting and heating furnaces for copper and copper alloy production by increasing the rate of heat transfer from the flame to the product. The increased productivity and energy savings obtained from this technology can result in sizable reductions in operating costs for smelting operations.

Jan 1, 1991

By T. K. Akopyan, E. A. Naumova, V. V. Doroshenko, N. A. Belov

"A qualitative and quantitative analysis of the new Al-Ca-Mn-Fe phase diagram in the region of the aluminium corner is carried out using both thermodynamic calculations and experimental methods. Using the obtained data, the principal possibility of creating both cast and wrought sparingly alloyed aluminium alloys with calcium, manganese, scandium and zirconium at allowable iron contents of up to 0.4% that do not require solution treatment and quenching is justified. At the selected concentrations, the entire amount of manganese (1%) is practically included in the aluminium matrix, while calcium (~2%) and iron are in the multiphase eutectic, which has a fine structure. The joint introduction of 0.25% Zr and 0.1% Sc into the alloy leads to precipitation hardening due to the formation of the L12-Al3(Zr,Sc) phase during annealing. Based on the experimental data for the model multicomponent Al2CaMnFeZrSc alloy, it is shown that such alloys can combine high mechanical properties and good manufacturability during both casting and metal forming. This is due to the combination of a narrow temperature range of solidification with a fine eutectic structure.INTRODUCTION Hardening in branded aluminium alloys (both cast and wrought) is generally achieved by heat treatment of the T6 type, including quenching and artificial aging (Zolotorevskiy, 2007; Kaufman, 2004; Mondolfo, 1976). Heat treatment significantly increases the cost of the final products. Therefore, industrial companies are interested in developing alloys that can be hardened to the desired level without quenching. To solve this problem, alloys with scandium are the most suitable (Toropova, 1998; RØyset, 2005). This element (usually in an amount of ~0.3%) is one of the most effective hardeners in aluminium alloys, due to the formation of Al3Sc (L12) phase secondary precipitates, the size of which is less than 10 nm (Knipling, 2010; Fuller, 2005). These nanoparticles are formed during the annealing via decomposition of the supersaturated aluminium solid solution (hereinafter referred to as (Al)). This feature allows us to significantly increase the strength of aluminium alloys by simple annealing (at ~300°C), i.e., without heat treatment, including quenching. However, scandium is a very expensive metal, so its use as an additive is severely limited. The most effective method is the introduction of scandium together with zirconium (Lefebvre, 2009; Booth-Morrison, 2012). The optimal combination is the introduction of ~0.1% Sc together with 0.20–0.25% Zr, which, according to (Belov, 2006), gives approximately the same strengthening effect as the introduction of 0.3% Sc."

Jan 1, 2018

By Xinyang Wang

It is believed that sulfur and volatile matter con-tents in coals are the main intrinsic properties to cause the self-heating of coal. Their oxidation at lower temperatures than that of fixed carbon to initiate coal's self-heating should be quantified. This study is aimed to improve the previous mathematical model developed by the authors for studying the coal's propensity for spontaneous combustion. It enhances the model's ability to consider the effects of sulfur, volatile matter and moisture contents in the coal three important factors affecting the coal's self-heating process. Sulfur exists in coal primarily in the form of pyrite which will be oxidized rapidly under suitable conditions. Volatile matters, higher in low rank coals, are more easily to be oxidized. Heat of water condensation provides initial energy for low temperature oxidation. Heat release rates for pyrite oxidation and moisture condensation are built in the model. Finally, the simulation results in terms of time versus temperature on pyrite oxidation and moisture condensation are validated with the adiabatic testing data respectively.

Jan 1, 2013