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By F. L. Sizer

SOME old-time views which have recently come into my possession have inspired me to record that part of the early history of Leadville, Color- ado, with which I am familiar, the years 1878 to 1882, in the hope that others will add to what is here mentioned. My first appearance in Leadville was in June, 1878, immediately after graduation from the University of Michigan, and I found a congenial and lively crowd of young men, already there. The old log hotel, at the corner of Pine and State streets, housed some distinguished guests in the summer and fall of 1878. It was my good fortune there to make the acquaintance of James B. Grant, afterwards Governor of Colorado, in July of that year, when we were both glad of the accommodation afforded by cots in the second floor loft of the hostelry presided over by Herman Hibschle. Grant was then building his smelter and our associates were Eddy and James, August R. Meyer, and Berdell and Witherell. The Grand Hotel-Harris and Walsh, pro- prietors-was the first-class hotel of the place; but in a very few months there were many competitors.

Jan 1, 1924

By J Franke, C Gonzalez

One of the regular tasks of geotechnical and mining engineers is the measurement and management of deformation in underground excavations. Although several methods are used to do so, the incumbent methodologies for monitoring deformation and ground support serviceability are limited to the use of visual observations or measurements at discrete points, resulting in a qualitative assessment only. The introduction of LiDAR technology allows a quantitative assessment across the entire excavation volume and its rock surface, by collecting a full three-dimensional image of the entirety of an excavation such as an underground drive, decline, or a tunnel. Comparisons between epochs of complete 3D data coverage allows for change detection over time that doesn’t feature otherwise typical omissions. The implementation of regular scanning has shown to be highly advantageous for mines with swelling or squeezing ground, but also at mines with rapid deformation. Despite the LiDAR potential, its adoption has been slow. A key reason for that is that working with point clouds is foreign to most geotechnical engineers. Point clouds have long been the realm of surveyors, but to fully adopt their use in geomechanics requires retraining, upskilling, and devotion by the individuals and the company. Sites are already stretched, so often there are insufficient resources to be applied to bringing the new technology into use. The solution to this hurdle is to partner with subject matter experts to achieve the desired high-quality outcomes without the commitment of time by geotechnical personnel. This paper presents a new solution of fully automated raw LiDAR point cloud data processing that not only enables geotechnical engineers to avoid having to learn unrelated skills by allowing for deformation monitoring without associated training or expertise, but it also provides instant reporting results as well as a sophisticated database with features otherwise not available. All data processing time and effort is completely replaced by an automated process which at the same time opens up the opportunity to monitor many more excavation volumes at a higher frequency than is possible with conventional tools and methodology.

Nov 29, 2022

By H. C. W. Bosman

"Over the past five years, contributions from geologists and mining engineers were instrumental in the successful development of MEPS. It is a system of FORTRAN programs specifically designed to be used by mining personnel to solve geological and mining problems. MEPS is a flexible keyword-driven system. Extensive error editing procedures significantly reduce the time required to proceed from problem recognition to solution. Possibly the most attractive feature of MEPS is that computer solutions may be guided or selectively modified to obtain desired solutions. Some highlights of MEPS are:1. Vocabulary that is familiar to mining people.2. Geological data storage and retrieval.3. Statistical analysis and variograms.4. Contour maps of assays and geological horizons.5. Trend surface analysis with residual evaluation.6. Ore reserve calculations.7. Open-pit mine design.8. Marginal profitability calculations on pit walls.9. Production scheduling.10. Vertical cross-section plots indicating pit outlines, ore grade contours and selected geological horizons."

Jan 1, 1973

By John E. McCullough

The purpose of this development program is to design and develop a known volume air sampling pump for use in measuring the amount of radio-active material in the atmosphere of an underground uranium mine. The principle nuclear radiation hazard to underground uranium mines comes from the mine atmosphere. Daughter products of 222-radon, namely 214-polonium, 214-lead, 214-bismuth and 214-polonium, are inhaled by the miner, resulting in a relatively high lung cancer rate among these workers.

Jan 1, 1976

By W. T. Thom

In previous classifications of coal, it has been customary to regard moisture eliminated from coal samples between 20 and 100 C. as extraneous matter, rather than as a constituent part of the coal. It seems, however, that the physical character and use properties of the low-rank coals are directly related to the amount of such moisture present, and recent chemical work has shown' that such coals contain unstable groupings which decompose between 20 C. and temperatures somewhat above 100" C., with the splitting off of moisture. According to this view, the moisture eliminated from air-dried coal below boiling point is similar in all essential respects to moisture eliminated above 100" C., and is produced by analogous reactions; and inasmuch as the moisture given off above 100" C. has always been treated as a constituent of the volatile matter of coal, it would seem that consistent usage would include as a part of the volatile matter all moisture present as an essential component of the coal as it occurs in nature. As a matter of experience, it seems clear that the general physical and chemical characteristics of the low-rank coals are largely determined by or related to the moisture, whether chemically or physically combined, present in air-dried coal; it is also demonstrable by trial that the low-rank coals cannot be satisfactorily classified on a purely chemical basis by using the moisture free form of analysis. The low-rank coals of the western United States include numerous well-defined types, many of which were referred to in a classification proposed by Ashley,2 in which the physical and use properties of the coals were made the primary basis for their systematic grouping. When testing this classification by replotting analyses of these type coals according to the Seyler scheme of classification,3 a satisfactory parallelism between use properties and chemical constitution of the dry coal was found among

Jan 1, 1925

The price of oil and other minerals may not make the costly business of offshore exploration seem -attractive at present. There is little doubt that the future search for the strategic resources will tend towards deeper waters particularly on the continental slope margins. In addition with the realisation that active tectonic environments (eg the Makassar Straits) cannot be excluded as potential hydrocarbon sources there is an increasing demand by the explorationists for deep water survey capability. Such deep water research has until recently been restricted to a few specialised academic institutions ;however with the anticipated extra, demand from other institutions, companies, and government agencies, Marconi Underwater Systems Limited (MUSL)and the Institute of Oceanographic Sciences in the UK have come together to allow MUSL to provide the deep water mapping system GLORIA on a commercial basis -for the first time. The GLORIA package comprises a deep water(more than 400m) side scan sonar system which, by operating at a frequency around 6.4 kHz can insonify swathes on the seafloor up to 60 km wide. In addition, single channel seismic, 3.5 kHz high resolution profiles, precision echo sounding, magnetic and gravimetric data all combine to provide as complete a regional interpretation as possible. The GLORIA system combines surveying at a reconnaissance level, covering as it does up to 20,000 sq.km per day, with a very high reliability, so that even in- economically unfavourable times, it can-still be considered as an invaluable and cost effective primary exploration tool. Analysis of the GLORIA data enables the identification of areas of particular interest requiring more detailed study by the more costly multi-channel seismics at a later date.

Jan 1, 1987

China's coal energy development, characteristics and relationships with atmospheric pollution are reported. Atmospheric pollution sources from coal combustion are analyzed. Some of the projects for clean coal combustion in the Shanghai area include use of industrial briquettes, investigation of coal combustion additives, and blending combustion of coal with industrial wastes. Coal is China's main energy source, and 80 percent of China's annual coal production is used in combustion devices. Coal-flue gases from the domestic stoves and industrial furnaces are the main atmospheric pollution source. China's atmospheric pollution is, in fact, the pollution of coal-flue gases. To 2000, in view of China's energy needs as a developing nation, the atmospheric pollution from coal combustion must receive our utmost attention.

Jan 1, 1994

By I. Fatt

A recently developed system for measuring electrical resistivity of liquids without use of electrodes offers some interesting possibilities in electric logging technology. The equipment as supplied by the manufacturer is satisfactory for continuous mud logging on a drilling rig or for measuring mud or filtrate resistivity in the laboratory. A simple modification of the commercially available instrument makes it suitable for measuring resistivity of core samples in the laboratory. The continuous measurement of mud resistivity on a drilling rig is a convenient means for detecting mixing of formation water with the drilling mud. Such information is useful to the geologist, the mud engineer and the logging engineer. However, continuous mud resistivity logging by conventional electrode-type resistivity cells is beset with difficulties. The mud, sand and rock chips abrade the electrodes, thereby changing the cell constant and eventually destroying the cell. Also, additives and crude oil in the mud may poison the electrodes by coating them with a nonconductive material. An electrode-type resistivity cell. therefore, may give erroneous readings under certain conditions. Electric logging companies circumvent the electrode poisoning problem by using a four-electrode resistivity cell for measurement of mud resistivity. In this cell, change in electrode area does not change the cell constant. However, the four-electrode cell is difficult to adapt for continuous reading and does not solve completely the problem of electrode abrasion by the sand and cuttings in the mud. The measurement of electric logging parameters on core samples in the laboratory encounters some of the same problems discussed in connection with mud logging. Ideally, the electrical resistivity of a core sample should be measured by placing platinum black electrodes in direct contact with the plane ends of a cylindrical or rectangular sample. Platinum black electrodes however, are much too fragile and easily abraded to be brought in contact with a rock sample. Also, oil or other constituents in the fluid contained in the sample will poison platinum black. In practice, gold-plated brass electrodes, in an AC bridge circuit operating at about 1,000 cps, are used for routine core analysis. For more precise work in research studies, a four-electrode scheme is used.',' Preparation of the samples for the four-electrode method is much too involved for routine core analysis. An apparatus for measuring resistivity of liquids without use of electrodes was described by Guthrie and Boys3 in 1879. They suspended a beaker, containing the electrolyte, by a torsion wire and rotated a set of permanent bar magnets around the vessel. The eddy currents induced in the electrolyte reacted against the rotating magnetic field to develop a torque, which was measured as a deflection of the torsion wire. In 1879 this method could not be made precise or convenient because of the lack of strong permanent magnets. The writer described a very greatly improved apparatus similar to that of Guthrie and Boys, but it was not suitable for continuous measurements or core samples.' Many electrodeless resistivity devices using radio frequency current are described in the literature.5, 6 These generally are suitable only for noting the end-point in a chemical titration. They do not measure resistivity, instead measuring a complex quantity which includes the dielectric constant and the magnetic permeability. The first description of the apparatus to be discussed in this paper was given by Relis.7 Improvements and modifications are described by Fielden,s Gupta and Hills,> and Eichholz and Bettens.10 DESCRIPTION OF APPARATUS The apparatus used in this study is based on the principle that the solution under measurement can form a loop coupling two transformer coils, as shown in Fig. 1. For a fixed AC voltage applied across Coil A, the voltage appearing across Coil B is a function of the resistance of the liquid-filled loop. The details of the voltage generating and measuring circuits are given in Refs. 7, 8, 9 and 10. A block diagram of the equipment is given in Fig. 7. Special features worth mentioning are the operating frequency of 18,000 cps and the automatic temperature compensation which results in the given resistivity readings being automatically correlated to 25°C. The liquid loop supplied by the manufacturer, shown in Figs. 1 and 2, was modified for use in core analysis (Fig. 3). The core sample under test is substituted for a section of the original loop. As shown in Fig. 3, the unit accepts only plastic-mounted cylindrical core specimens. A Hassler-type sleeve easily can be designed for the unit if unmounted cores are to be measured. EXPERIMENTAL PROCEDURE MUD LOGGING A simulated mud line was set up in the laboratory.

By R. D. Lawrence

"Comparable transaction analysis is the best known of the market approaches to valuation of exploration-stage mineral properties. The analysis of option and farm-in agreements can also provide useful guidance to valuators. While such approaches can be distorted by incomplete analysis, market-based methods are capable of providing consistent, credible results when carried out carefully with due consideration paid to all factors which buyers and sellers consider when dealing in the real market. IntroductionMineral properties without defined resources present one of the most challenging tasks to the mineral valuator. This paper will concentrate on market-based approaches to valuation of such properties. Other authors at MM2000 presented papers on cost and income approaches. Sorentino (2000) also provides a useful overview with some provacative commentary on methods.Market based-approaches are based on the principle of substitution and include such techniques as: comparable transaction analysis (sometimes referred to as sales comparison analysis); farm-in commitment (or option agreement) analysis; rules-of-thumb; and comparable market value analysis.Are there any valuation standards available to assist the valuator? In Canada there are none that apply to the valuation of mineral assets or securities. This problem is being addressed, at least in part, by the CIMVal Committee of the Canadian Institute of Mining, Metallurgy and Petroleum (CIM)1. Further, the recently established Canadian Association of Mineral Valuators will be giving consideration to the adoption of valuation standards."

Jan 1, 2002

By B Shi, Y Li, L Ma, F Zhou

Subsurface fires are a common threat to coal mining, as spontaneous combustion of coal can potentially result in gas combustion and explosion. Fire-proof techniques, such as grouting, foam, or colloid injection, are not in a position to function ideally, due to the limited coverage and stopping the extinguishment substance from reaching the fire location. Liquid nitrogen, as a kind of all-submerged fire prevention or extinguishing method, can rapidly extinguish fires, thus preventing gas explosion and minimising extinguishment time. Injecting liquid nitrogen through boreholes is an important way during the period of mine catastrophe. But liquid nitrogen is not effective enough in infusion; technical issues restrict the development and utilisation of liquid nitrogen fire prevention and extinguishing technology. Immediate infusion of liquid nitrogen is usually associated with ‘air slug’ (the balloons and bubbles in the pipeline which hinder the flow of low-temperature liquid), which blocks pipelines for liquid nitrogen injecting. Another issue is that the pipeline tends to be damaged due to freezing, which undermines the injecting efficiency of liquid nitrogen and its application result. In order to solve the problems of the low efficiency and some other related field issues in liquid nitrogen perfusion, the ground–underground high efficiency liquid nitrogen injection technology were developed. Implementation of liquid nitrogen infusion techniques in Chinese coalmines achieved the goals of fire prevention and air-cooling. The technique presented in this paper is efficient in absorbing heat, and consequently, displacing oxygen and combustible gases. Field tests at Rujigou and Yangchangwan Coalmine justified the efficiency of the technique. By using this technique, there was no waste left behind, which may impede the subsequent production. The presented technique is of great benefit to the social, economic, and environmental aspects of mining operations, and will have broad applications in fire prevention for large-scale coalmines.CITATION:Zhou, F, Shi, B, Li, Y and Ma, L, 2015. Key techniques and engineering applications of stereoscopic liquid nitrogen infusion for coalmine fire prevention, in Proceedings The Australian Mine Ventilation Conference, pp 291–298 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Aug 31, 2015

By J L. Macdonald, G S. King

"The development of a predictive geometallurgical model is a multidisciplinary and iterative task that involves both discovery and integration aspects. In this paper, the authors discuss the concepts of geometallurgical modelling in terms of the underlying relationships that are used to connect geology, metallurgy and economic value, and how the early-stage preparation of a spatial geometallurgical model enhances project value and provides a sound basis for future studies and test work programs.Hot Chili’s (copper-gold-molybdenum) Productora Project, which is located in northern Chile, is a porphyry-copper style deposit that can be exploited using open pit mining and preparation of a saleable concentrate from fresh ore, as well as heap leaching, solvent extraction and electrowinning (SX-EW) extraction of copper from oxide ores. To enhance project value in the Productora prefeasibility study (PFS), Hot Chili developed a geometallurgical model that was used to predict the process responses of both sulfide and oxide ores. The Productora model incorporates test results from mineralogical, metallurgical and comminution testing, as well as other studies completed on a suite of samples collected from the many geological domains of the deposit.Using Bond Work Index and Abrasion Index proxies in the geometallurgical model, Hot Chili estimated the variability of sulfide ore throughput and comminution costs. Heap leach acid consumption in oxide ore was estimated from drill hole calcium concentrations. The model was then used in mine scheduling to identify high and low throughput or high and low acid ore zones so that the processing of these zones could be advanced or deferred to improve net present value (NPV). Additionally, the cost benefits of preparing an early-stage geometallurgy model were quantified through a comparison to a conventional model that was based on test work averages.CITATION:King, G S and Macdonald, J L, 2016. The Business Case for Early-stage Implementation of Geometallurgy– an Example from the Productora Cu-Mo-Au Deposit, Chile, in Proceedings The Third AusIMM International Geometallurgy Conference (GeoMet) 2016, pp 125–134 (The Australasian Institute of Mining and Metallurgy: Melbourne)."

Jun 15, 2016

By G. R. Palmer

Using a fluidized, countercurrent multiple-compartment ion-exchange (MCIX) column previously developed by the Bureau of Mines, Bureau researchers have successfully extracted uranium from a simulated acidic in situ leach liquor that contained 150 ppm U30s? This successful demonstration of the MCIX system is reported, and the effects of varying the operating conditions on the performance of the system are also examined. Operating the MCIX system with a flow rate of 15 gpm/ft2 and an aqueous-to-resin flow ratio of 200:1, more than 90 percent of the uranium Has extracted, and a resin containing approximately 28 grams U308 per liter was produced. The absorption column used to investigate the operating variables was approximately 18 feet long with a 2-inch ID and was divided into compartments that were 1 foot long.

Jan 1, 1980

By M. H. Govett, G. J. S. Govett

"The current American ""energy crisis"", occurring in the midst of a global debate on the adequacy of mineral supplies to support present and projected levels of world consumption, has focused attention on Canada as a major world producer of minerals. Exports of minerals account for approximately one-third of Canadian foreign earnings; more than half of these exports are to the United States. Although the United States is a net importer of most industrially important metals, with the exception of nickel and zinc, only a small part of American mineral imports are from Canada; these imports are minerals for which geographical proximity and strategic considerations are important. In the short-term, Canada is more dependent on her exports to the U.S. than America is on imports from Canada. It is argued that Canada, far from indulging in economic nationalism to preserve her resources, should expand her exports while the markets are available."

Jan 1, 1973

By James M. Neilson

In contrast to the rather generalized title of this paper, the subject of discussion will deal with two specific cases of sliding in glacial lake clays in northern Michigan. The slides in question occurred on lands owned by the Upper Peninsula Power Company a short distance south of Lake Superior. Slope failure problems have plagued the Company's operations for many years. It is hoped that this paper may provide some insight into the causes and possible mechanisms of clay slides in general as well as providing details of the two slides specifically cited. LOCATION The Upper Peninsula Power Company's Victoria facilities lie in section 29, T. 50 N., R. 39 W., in Ontonagon County, Michigan. The power site is situated on the West Branch of the Ontonagon River, approximately five miles southwest of the town of Rockland and only one mile to the southeast of the old mining location of Victoria. The area lies wholly within the Precambrian Shield and it is geologically similar to adjacent parts of Wisconsin, Minn¬esota, and Ontario. (Figure 1). THE VICTORIA HYDROELECTRIC SITE The Victoria hydroelectric power facilities were constructed in 1930 on a portion of the West Branch where meanders are conspicuously developed. The generating station is actually sited on an abandoned meander at a place where valley widening has occurred. Water is conducted from Victoria Dam through a 6000-foot, 10-foot diameter wood stove pipe - through a surge tank - and into the powerhouse where

Jan 1, 1971

By C. M. Fellman

AVAILABLE data for the first nine months of the Year indicate that accident occurrence in metal mining was well on its way to an all-time low for 1939. However, the relatively rapid pickup in mining production in the fall will be likely to boost both accident occurrence and also accident rates. Results of the National Safety Competition for 1938, the fourteenth of its kind conducted by the U. S. Bureau of Mines, were published in August, 1939. W. W. Adams, statistician of the bureau, states that "with 345 mines and quarries competing, more than in any previous year except 1931, the contest revealed low accident rates at many of the enrolled plants and, which is even more remarkable, it revealed 113 mines and quarries at which no lost- time accidents occurred during the con- test year." The National Safety Competition provides a means whereby mines and quarries may engage in active competition to stimulate their safety programs. Companies in the contest can compare their records with those of similar plants operating elsewhere and thereby determine to what extent their safety programs are successful. The Joseph A. Holmes Safety Association gave over 150 awards for safety performance in the mineral industries in 1939 and a remarkable phase of these awards was the considerable number given to individual miners who had worked fifty or more years without sustaining a lost-time accident.

Jan 1, 1940

By Kapila Pathirage, Michael S. Schultz, Gregory Sanders, Ulf G. Gwildis

Adequate understanding of the subsurface conditions along the alignment of a planned tunnel is key for managing project risk. For achieving this understanding, geotechnical borings are conducted during design. Where their spacing cannot reduce the risk of encountering differing site conditions (DSC) in-between borings to an acceptable level, supplemental exploration methodologies or data evaluation approaches may be required to bridge the data gap. This paper compares the exploration design approaches of recent tunnel boring machine (TBM) and microtunnel boring machine (MTBM) projects in the quaternary deposits along the Eastern Seaboard, the glacial geology of the Pacific Northwest, the sedimentary rocks of the South, and metamorphic rocks in western Germany, describing their respective effectiveness of managing DSC risk.

Dec 1, 2022

By Dominic Fragomeni

"The mineral processing industry has had a long history of innovation that is recognized but not often celebrated. These include significant advances in mineral measurement, testing, comminution, mineral separation and process control technologies that have transformed mineral assemblages into ore.This presentation presents some of the major mineral processing innovations and the impact they have had on our industry. As we look to the future, it is critical that we innovate and change. We will explore some examples of the next developments and how they can be catalyzed in the face of risk management, lower metal price cycles, resource constraints, inertia and the challenge of short term value delivery."

Jan 1, 2017

By R. Schlüter

"The “Biohydrometallurgical Center for Strategic Elements (BHMZ)” is a cooperation of 13 departments of the Technical University Bergakademie Freiberg fostering interdisciplinary research along the whole (bio-) hydrometallurgical process chain to extract indium and germanium from sulphide ores. Research comprises methods to (i) bring the respective metal from the source material into aqueous solution and (ii) different approaches to extract pure metal or metal-containing materials from the solution. Within the BHMZ the Department of Underground Mining Methods deals with the design and implementation of an underground testing facility for bacterial in-situ stope leaching in its own “Research and Educational Mine”. The intention is to investigate innovative approaches for leaching technologies by crack initiation due to hydraulic fracturing or water pressure blasting under consideration of leaching kinetics and underground conditions. It is planned to set up two testing units comparing energy input and the metal output of conventional (blasting) as well as one of the innovative technologies. Aim of subproject is to establish an innovative and sustainable method ready for up-scaling. BACKGROUND Metals like copper and zinc mainly occur as sulphide ores in nature. Due to the insolubility of these sulphide minerals the respective metal is commonly extracted by pyrometallurgical processing methods. These methods require several steps of enrichment of concentrates such as flotation and roasting (Figure 1) under extensive energy utilization. Additionally, this arouses the emission of sulphur dioxide gas which can have a negative impact on the environment in form of acid rain, as long it is not caught by sulphuric acid facilities (Schippers et al. 2011). However, to treat the ore on the surface either open pit or underground mining operations are necessary. This implies operation steps from excavating, loading, and conveying/hauling, to dumping with the sub-processes crushing and stashing. Due to the tendency of increasing depth, more complex ores and decreasing ore grades of the mineable deposits as well as increasing energy and environmental costs these conventional mining and processing methods become in general more costly and difficult to apply. Hence, hydrometallurgical processes and especially the suitability of bioleaching as an alternative in-situ method for future mining projects should be examined. Leaching by means of microorganisms is a combination of mining and processing by converting the insoluble metal into an aqueous form. This technology is an economically beneficial and environmentally friendly alternative to pyrometallurgical processing methods especially for primary and secondary low grade ores. Mainly the extraction of copper but also of zinc and lead from sulphide ores is state-of-the-art in surface leaching operations like heap and dump leaching (Figure 1)."

Jan 1, 2015

By James D. Pile

Following a methane ignition in the active panel of a longwall coal mine, the affected panel was successfully isolated from the rest of the mine. This allowed for the remainder of the mine to return to regular operation, and the conventional practice of having to seal the portals for a defined period of time was avoided. After the affected panel had remained isolated for a regulatorily mandated period of time, it was reopened in preparation for longwall face recovery. As it was not possible to move the shields from their existing positions to facilitate the installation of recovery mesh prior to shield recovery, alternative methods had to be considered to stabilise the gob and minimise flushing, thereby improving operator safety. The objective of the paper is to show how stabilisation of the gob was achieved during shield recovery, thereby minimising flushing, and improving operator safety. Phenolic foam was chosen and injected from between the shields into the gob behind them. This is a technique that has been used to great effect in Germany, to a lesser extent in Australia, but not knowingly to date in the United States. To ensure nothing was left to chance and thereby guarantee the project?s success, the procedure used in Germany was employed, down to the application of equivalent hardware, which was sourced through the North American supplier.

Jan 1, 2013

By R. Clark Lantz, Charles Stanley, David E. Hinton

Morphometric examination of lung alterations following exposure to toxic and pathogenic substances is invaluable in detecting subtle changes which might otherwise be overlooked. Results, from evaluation of initial structural alterations, support and guide subsequent nonmorphological techniques and, when coupled appropriately, can lead to a better understanding of the pathogenesis of a disease. Morphometry is a technique which can be used to determine, quantitatively, the site, extent, development, and progression of a disease state. Determination of the extent of tissue and cellular involvement in the response to inhalation of silica has been performed in order to gain a better understanding of the development of fibrosis following inhalation of this toxicant. In addition, since silica has been postulated as one of the important pathogenic minerals in coal mine dust' it is important to understand the lung tissue response to silica prior to evaluating the effects of inhaled coal mine dusts. Male Syrian golden hamsters were placed in Hazelton 1000 inhalation chambers and were exposed to either filtered air (controls, n = 24) or filtered air plus 30 mg!m3 silica (Min-U-Si110,95%ofparticles < 5 um,n =24)for16hours per day, five days per week, for two weeks. Animals were returned to the animal quarters prior to subsequent tissue processing at 1, 4, and 12 weeks following exposure. This schedule was designed to allow time for the development of fibrosis. Lungs were fixed by intratracheal perfusion of ½ strength Karnovsky's fixative at a pressure of 20 cm H20 and tissues were taken for embedment and analysis at the light level. Determination of site, extent, and development of alterations was performed using a multitiered approach. Changes in large structures (airways, blood vessels) was determined prior to evaluation of changes at the septal tissue level. Data will be presented outlining the progression of changes. Results indicate the usefulness of morphometric analysis of lungs following inhalation of toxic substances in quantitatively defining the structural alterations.

Mar 1, 1989