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By Fernanda Borba Simões

Na produção de biocombustíveis a partir de óleos vegetais produzidos via craqueamento térmico-catalítico, é realizada a desacidificação do produto final para sua viabilidade, podendo ser efetuada pela adsorção. Os adsorventes são diversificados e vão desde zeólitas até o uso de resíduos industriais. Este trabalho buscou testar a lama vermelha previamente ativada quimicamente e termicamente como adsorvente de ácidos graxos livres presentes no gasóleo leve produzido a partir do craqueamento do óleo de palma com índice de acidez inicial de 55,1257 mg de KOH/g. A lama vermelha foi utilizada em cinco condições: seca sem tratamento, ativada quimicamente (pré-tratada a 400°C/2h) por solução de HCl a 37%, de H2O2 a 4%, de HCl a 1,5 M e de KOH a 1,5 M. Na cinética de adsorção, a lama vermelha ativada por solução de HCl a 1,5 M mostrou-se mais eficiente que os demais adsorventes, pois reduziu o índice de acidez do biocombustível de 10,7574 mg de KOH/g para 9,1752 mg de KOH/g no tempo de 50 minutos. Quanto à eficiência dos adsorventes restantes, no que tange a desacidificação, apenas a lama vermelha seca e a ativada quimicamente por KOH a 1,5 M apresentaram remoção dos ácidos graxos livres perceptíveis.

Aug 16, 2017

Sampling protocols and metallurgical flow sheets should be designed to suit the style of mineralisation in question. In support, the a priori need for evaluation programs is the characterisation of the mineralisation type(s) and domain definition. The proportion and size of gold particles has a direct impact on the effectiveness of sampling protocols and metallurgical processes employed. Within the coarse- to-fi ne gold spectrum, the samplability of a deposit ranges from relatively simple for fine-grained disseminated particles, through to difficult for coarse gold mineralisation. Conversely, metallurgical processing may be relatively simple for coarse gold ore and more difficult for very fi ne gold ores. Most deposits contain a proportion of both particle size types. The nature of mineralisation, mineralogy and associated gold particle sizing can only be determined by preliminary sampling to facilitate testing. Mineralogical studies, focussing on ore mineralogy and gold particle deportment, size and distribution are required as part of wider paragenetic and geometallurgical investigations. This paper discusses key issues and presents a methodology for the determination of gold particle size in coarse gravity-gold ores to support sampling optimisation and which also contributes to metallurgical characterisation.

Aug 1, 2010

By H. R. Babitzke

To develop alloys suitable for use at elevated temperatures, columbium and tantalum were combined with tungsten, hafnium, vanadium, zirconium, and titanium, and the resulting alloys were evaluated with respect to fabricability, hardness, Electrical resistivity, strength at elevated temperatures, oxidation resistance, and bend transition. Of the 23 compositions tested, Cb-2OHf-5W-10Ti exhibited superior high-temperature properties. A recrystallized sample of this alloy was fabricable at room temperature, had a strength of 44,000 psi at 1,200° C, and had an oxidation rate of only 7.7 mg/cm2/hr at 1,000° C.

Jan 1, 1966

By Dennis V. D’Andrea, Peter G. Chamberlain, James J. Olson, William C. Larson

Blasts designed for in situ copper leaching must produce adequate fragmentation and permeability for successful leaching. Copper recovery depends to a large extent on the particle size distribution created by the blast, the permeability in the blast- fractured zone, and the ability to maintain solution flow with a minimum amount of channeling. This paper presents the results of Bureau of Mines experiments where core drilling was used before and after blasting to establish the degree of fragmentation. Data are presented from tests at the Sierrita mine of Duval Corp., and also from tests at the Emerald Isle mine of El Paso Mining and Milling Co. Copper recovery is predicted from fragment size distribution data using a computer model. Data from several blasts are used to show how predicted copper recovery is related to powder factor.

Jan 1, 1977

From a distance, the 0.75-km (0.5-mile) rail line that sits in the shadows of Vale-Inco?s Stobie Mine outside of Sudbury, Ontario could be mistaken for a standard conveyor belt hauling ore from the nearby mine. But with its large, yellow-painted loop and interconnected green rail cars that invert themselves on the loop before correcting with a smooth rollover further down the track, one might assume that this is some sort of test track for a new roller coaster. The fact of the matter is that it is the proving ground for Rail-Veyor technology, a technology that the company hopes will one day change the face of ore transportation in surface and underground mines around the world. With a line of linked, low-profile rail cars that are capable of carrying up to 1 t (1.1 st) per car of ore by way of simple, above ground, lightweight rail track, the technology is not groundbreaking. In fact, it was developed in the 1960s for the French State Railroad. A demonstration plant for the Florida Institute of Phosphate Research was installed in 2000 and the first commercial under-ground installation was in 2007 in South Africa at Harmony Gold?s Phakisa Mine. There, a 4.7-km- (2.9-mile-) long tram between two shafts operates three Rail-Veyor trains on a shared track. The difference is that the application that is being tested day-and-night in Sudbury is getting closer to wide production, thanks to the use of computer controlled automation that has helped turn an old idea into a cost-effective modern solution.

Jan 1, 2010

By J. Pereyra, M. DeMarco

"INTRODUCTION It can be vital that bolted joints holding subassemblies together remain secure. Bolts should resist the loosening effects of vibrations and dynamic loads yet need to be easily removable during maintenance. When a threaded fastener is subjected to vibration, the rapid movement causes a lowering of friction against the threads and a subsequent loss of preload. The loss of preload allows the fastener to vibrate loose and possibly fall out. As the diameter of fasteners increase desired preload becomes increasingly more difficult to achieve. Input torque requirements for achieving proper bolt preload is exponentially related to any given fasteners diameter. This means that specialized tooling or bolting practices are usually required to attempt the tightening of fasteners to reach their required preload. Traditional methods can cause problems with joint integrity and do not provide consistent bolt load across the bolted surface. BOLTED CONNECTIONS A failed critical bolted joint can lead to high maintenance costs, machine downtime, and risk to worker safety. Control of the clamp load in a bolted joint is vital. However, when faced with a problem joint, it is not surprising that the design engineer will not have an answer if asked about the clamp load. Torque calculations must always be based on the existing conditions that often are vague. Unless all parameters are correct, the calculation will be unreliable. Examples of parameters are: • Thread condition of the fasteners • Hardness of contact surface • Material (steel, aluminium, copper, etc.) • Extra friction from a locking fastener • Extra friction from an adhesive • Lubricant on the thread • Type of bolt head (flanged, regular or serrated) • Surface coating of the bolt • New or reused fastener During tightening, bolts are subjected to both tensile and torsional stress. The total stress in a bolt can be calculated using the formula: Total stress = vsx2 + 3txy2 In order to maximize the desired tensile stress (sx) it is vital to minimize the torsional stress (txy). Tensile stress (clamp load) is achieved when the bolt is axially elongated. Unwanted torsional stress (twisting) in bolts arises during tightening due to thread friction. High thread friction increases torsional stress and causes yielding at lower clamp load levels than normal. A lubricant is necessary to minimize the malign torsional stress. However, many commonly used bolt-locking systems are based on increased thread friction (deformed nuts, adhesives, etc). To minimize thread friction and concurrently safely secure the joint has often incorrectly been considered impossible. The use of locking systems that increase thread friction is the single most common reason why the full capacity of bolted joints is not utilized. The following example illustrates the problem."

Jan 1, 2015

By Miguel Angel Ibarra

This paper describes the results of a digital computer simulation study in which the impact of the proposed truck dispatching on the overall mine productivity was investigated for an operating open pit mine. In the study, the existing operation was first simulated for a one-month period, using both the actual time study data and the computed cycle times. By adjusting certain input parameters to the simulation program, the actual one month production was first duplicated through simulation. Afterwards, the operation was again simulated in a dispatch mode. Comparison of simulation results under the dispatch mode, with the initial base case simulation results, showed a definite improvement in overall productivity with dispatching; i.e., approximately 10% gain for the operation. As expected, the results also showed that the extent of possible improvement did vary with the particular pit configuration being investigated.

Jan 1, 1980

By Ruckmick J. C.

Elemental sulphur occurrences are widely distributed in two geological environments: -1-Basins containing hydrocarbons and zones of Cenozoic vulcanism. However, very few of these constitute deposits large enough to be of commercial importance. Almost all of the elemental sulphur mined in the world comes from bioepigenetic deposits in petroliferous basins. These deposits occur in two general structural styles: diapiric (salt domes) and stratiform. Examples of diapiric deposits occur in the Gulf Coast basins of Texas, Louisiana, and southern Mexico. Examples of stratiform deposits occur in the Fergana and Amudarya depressions of Central Asia, the Mesopotamian Depression in Iraq, the Cis-Carpathian Trough in Poland and Russia, and the Permian Basin in Texas. Economic bioepigenetic sulphur deposits range in size from approximately 1 million tons of sulphur in the smaller salt dome deposits to more than ZOO million tons of sulphur at the Mishraq stratiform deposit in Iraq. Total world production from bioepigenetic deposits amounts to approximately 16 million tons of sulphur per year, one-half of the world's present annual consumption of elemental sulphur. Most of the balance of the annual consumption is recovered from sour gas and petroleum. All bioepigenetic sulphur deposits share remarkably similar origins and characteristics. They are formed by anaerobic bacterial replacement of gypsum or anhydrite in tilted basins where evaporite beds are underlain by petroleum. Figure 1 illustrates a generalized cross-section of a salt dome sulphur deposit. Figures Z, 3, and 4 are cross-sections of three types of stratiform sulphur deposits. In terms of sulphur genesis, the only significant difference between the salt dome and stratiform deposits is that the positioning of the anhydrites above the petroleum in the salt domes is caused by diapiric rather than sedimentary processes. In the salt domes, the residual anhydrites of the cap-rocks are accumulated by solution and removal of halite by artesian ground waters.

Jan 1, 1978

By J Zhang, L Klemettinen, A Jokilaakso, J Biswas, J Partinen, H O’Brien, A Klemettinen

Waste lithium-ion batteries (LIBs) are important secondary sources of many valuable materials, including Critical Raw Materials (CRMs) defined by the European Union (EU): lithium, cobalt, manganese, and graphite. Additionally, LIBs typically contain nickel and copper, which are classified as Strategic Raw Materials for EU since 2023. In recent years, great effort has been made to develop efficient recycling processes for waste LIBs. Pyrometallurgical processes have been essential in industrial production of metals for many decades. These technologies are relatively mature, with high adaptability for different raw materials. Pyrometallurgical treatment in LIB recycling typically involves the use of smelting processes, in which waste batteries are heated above their melting points and metals are separated through a reduction reaction in the liquid phase. Through this recycling route, cobalt, copper, and nickel can be efficiently recovered in the form of a metal alloy, whereas lithium and manganese are lost in the slag phase. The goal of this work was to increase the recoveries of valuable battery metals through a combination of hydro- and pyrometallurgical unit operations. First, industrial Li-ion battery scrap underwent a selective sulfation roasting stage, where the aim was to transform LiCoO2 and Mn-oxides into Li, Co and Mn sulfates. After roasting, the battery scrap was leached in distilled water with a solid to liquid ratio of 100 g/L at 60°C and recovered 95 per cent of Li, 61 per cent of Mn and 35 per cent of Co. After leaching, the solid leach residue was mixed with industrial Ni-slag and biochar, followed by reduction at 1350°C in argon atmosphere. The high-temperature smelting experiments were conducted as a function of time (5–60 mins) to investigate the reduction behaviour of battery metals. The results show that Co and Ni from the slag and leach residue can be efficiently recovered in the slag cleaning stage.

Jun 19, 2024

By Bart Blanpain, Muxing Guo, Bin Yang, Fei Wang

An experimental investigation of the precipitation behavior of the Dy2O3 containing slag during cooling was carried out in this work. The slag with composition 45 wt% SiO2—49 wt% CaO—6 wt% Dy2O3 was equilibrated at 1673, 1773 and 1873 K for 24 h in an argon atmosphere, and then quenched in water to determine the phase relations. The composition and microstructure of the equilibrated phases of the systems were determined by EPMA/WDS. The precipitation behavior of the REEs containing phases during cooling was studied by using an in-situ confocal scanning laser microscope (CLSM) observation technique combined with an infrared imaging furnace heating (IIF). Data resulting from this work aims to support further investigation on separation of rare earths from metallurgical slags.

Mar 1, 2018

By I. Gombköto

Mining and mineral processing operations are usually generating huge amount of tailings. These tailings often gives lots of maintenance work in order to protect environmental resources from heavy metals slowly leaching out of tailing are due to Acid Rock Drainage (ARD) process. Handling leakage could be active or passive such as using of Permeable Reactive Barriers (PRB). PRB?s are used worldwide treating underground contaminations, using different type of matrix materials. All generally used matrix material has its advantages and disadvantages such as selectivity, sensitivity of precipitation generation or not satisfying hydraulic conductivity. Nowadays cheap and effective matrix material which is ignorant to pore plugging caused by precipitation within the PRB could be one solution to the demands of the industry. The authors have been carried out an investigation at University of Miskolc on lignite as high humid acid containing material for determining the ability of heavy metal adsorption and pore plugging resistance. Moreover, using hydraulic and chemical simulation methods, complete PRB dimensioning protocol based on new lignite matrix had been introduced. Within the frame of this paper the results are going to be discussed.

Sep 1, 2012

By D. M. Muir

Thiosulfate offers a non-toxic alternative to cyanide for processing gold ores. The mechanism of leaching gold using ammoniacal thiosulfate solution is driven by the Cu(II)-Cu(I) redox couple and is complicated by competing ligands such as NH3 and S2O32-. It is shown that an understanding of the copper speciation and sulfur speciation is required to optimise this system. This paper presents Eh-pH and speciation diagrams for varying concentrations of Cu(II), S2O32- and NH3 and discusses the conditions under which various copper and sulfur species are stable.

Jan 1, 2001

By William H. Baer, George M. Carlton, Blake M. Loring

IT is a well known fact that age-hardening alloys remain in a supersaturated, or partially supersaturated, condition only for limited periods of time at temperatures below the solvus. In order to develop optimum properties by subjecting the quenched alloy to precipitation or age-hardening treatment at a specified temperature, it is necessary that the cooling rate be sufficiently high to maintain the required degree of supersaturation of the solid solution. In practical applications the size and shape of the specimens obviously have considerable influence on the rate of cooling and there is need for more information on the effects of various rates of cooling. Cooling rates of quenched aluminum alloys generally have been established by the type of quenching medium, the temperature of the medium and the dimensions of the specimen.1,2,3 Except for the work of Roth3 little quantitative information is available on the measurement of cooling rates of aluminum alloys and the significance of the influence of various cooling rates upon the mechanical properties. The purpose of the present investigation was to study the use of the Jominy test for aluminum alloys (Table I). EXPERIMENTAL PROCEDURE The material for this investigation consisted of extruded rods 1 ¼ to 1 ½ in. in diam. The chemical compositions were as follows: [ ] The modified L-type Jominy specimen with dimensions shown in Fig I was selected as the most convenient means for obtaining a wide range of cooling rates. The standard Jominy specimen was not satisfactory because its cooling rate was not sufficiently high. The four flat surfaces machined at right angles along the length of the L-type specimen to a depth of 0-015 in. facilitated the hardness measurements. The specimens were machined from the extruded stock with no intermediate forging. New specimens were used for each aging experiment. The specimens were given solution treatments of 2 hr duration at recommended temperatures in a Hoskins furnace (Table 2). The temperature of the furnace was maintained constant to ±3°C. No protective atmosphere was necessary because the thin film of oxide that formed on the surface of the specimens had no effect on the hardness measurements.

Jan 1, 1948

By C. A. Lavery

A DISCUSSION is presented of natural gas production and field processing equipment as now utilized in the gas producing areas of the United States, with reference to use of such equipment in Canadian gas areas. The scope of the paper is confined to a general description of various types and methods of using surface production equipment. The discussion is divided under two general groups: well-head production equipment, and field processing. The first will be concerned primarily with indirect heaters, separators, knockouts, and special versions of this equipment. The second major group includes the field processing equipment for handling natural gas. A delineation should be made here as to the meaning of field processing as used in this discussion. We will limit our term to mean such processing equipment as may be used in producing fields to process gas or its by products in a manner that does not require conventional plant practices either in operation or supervision. This covers such equipment as is necessary to complete preparation of gas for sale to pipeline and/ or is necessary to recover valuable components. Under this heading we will discuss glycol dehydration, solid desiccant dehydration, low-temperature separation, mechanical refrigeration, and desorbtion-stabilization. These are all processes involved in preparing gas for final sale or disposal. They do not include the more conventional and large-scale plant process systems.

Jan 1, 1956

By J. B. Mawdsley

A LITILE north of the geographic centre of the Province of Saskatchewan, 150 miles north of the city of Prince Albert, is a narrow green-stone and sedimentary belt of pronounced structural characteristics. This belt, generally known as the Sulphide Lake belt, is about two and a half miles wide. During the past three years prospecting has uncovered numerous gold-bearing showings occurring chiefly along the centre of the belt for a distance of at least nine miles. The number of these showings, the nature of some of them, and their relationship to strong structural features, make it altogether likely that intensive work will eventually locate ore-bodies that will be of economic importance. The discovery of gold in the fall of 1938 on the south shore of Mackay lake, about five miles northwest of the Sulphide Lake gold-bearing belt, indicates that there are neighbouring zones of interest. This paper, an attempt to outline the present status of the interesting mineralized belt, is based largely on the information gained on a five-day tour of this district, made in August, 1939, on behalf of the Department of Natural Resources of the Province of Saskatchewan. The Sulphide Lake belt is named after a small lake centrally located in it. This lake and others are just north and within short portage distances of some of the long bays along the north shore of Lac La-Ronge, an irregular, island-studded lake, about twenty miles in diameter, in relatively rocky Precambrian country, just north of the Palaeozoic contact. The fur-trading post and settlement of Lac La-Ronge is on the west shore of this lake and a road, now under construction, will shortly link this community with the city of Prince Albert. In the past, the most direct route was an indifferent canoe route, in part following Montreal lake and river; more recently, the aeroplane has made this section easily accessible.

Jan 1, 1940

By John V. Beall

The Mining Engineering Handbook is written primarily for persons interested in the economic extraction of minerals. Not everyone referring to this book will be knowledgeable about mining and, therefore, this section is intended to explain to interested persons the scope of mining as well as fulfilling the title of "Mining's Place and Contribution" among the industries of society. 1.1-MINERALS, ROCKS AND ORE In the year 1971, the number of known elements amounted to 104. Fifteen of these have been made only in the laboratory, others may have persisted from the primitive atmosphere, but, by and large, elements originated from magmas or igneous rocks of the outer rocky shell of the earth. Only eight elements constitute 98% by weight of the earth's crust. These are oxygen, 47%; silicon. 28%; aluminum, 8%; iron, 5%; and sodium, magnesium, potassium and calcium, less than 4% each. These common elements and the other less common ones are the building blocks of minerals, of which there are over 2,000 varieties. According to Webster: "A mineral is an inorganic substance occul.ring natura!ly in the earth and having a consistent and distinctive set of physical properties and a composition that can be expressed by a chemical formula. The term is sometimes applied to organic substances, such as coal." Thus, minerals are precise combinations of elements. Rocks, as distinct from minerals, are composed of assemblages of minerals. When minerals are found in sufficient concentration to warrant extraction by mining, the mineralized area is considered an ore deposit. The definition of ore is mineral that can be extracted from the ground at a profit. The economic connotation is implicit in the word ore. Since most of the useful elements compose such a small percentage of the earth's crust, the occurrence of ore deposits as we know them would not have transpired had not geologic processes concentrated the elements (see Sec. 4). 1.2-DEFINITIONS OF MINING TERMS Extensive coverage of the many descriptive terms used in mining may be found in a good mining glossary, such as is available from the Superintendent of Documents (see Sec. 35), but for convenience a number of the more common definitions are given here. Mining may be defined, as by A. B. Cummins, as the act, process or work of extracting minerals or coal from their natural environment and transporting them to the point of processing or use. Mining techniques are applied to extracting metallic minerals, such as ores of gold, copper, lead or zinc; to fuels, such as coal, anthracite, lignite and tar sands; and to nonmetallic minerals, such as lime-

Jan 1, 1973

By F. W. Bond

Predictive ground-water modeling is currently being applied to a wide range of engineering applications. In recent years models have been used to evaluate the effect of large ground-water withdrawals on regional water supplies; subsidence associated with overpumping; siting and design studies for chemical dumps; siting and safety aspects of nuclear waste storage; and heavy metal migration from disposal sites. Similar modeling techniques could be used to analyze water-related problems in the minerals industry such as mine dewatering (both open pit and underground), environmental and pollution control, and process water supply and disposal The objective of this discussion is to describe how ground-water models are being used to assist in the solution of water-related problems outside the industry and to extrapolate that use to mining problems.

Jan 1, 1980

By Lana Alagha, Fardis Nakhaei, Jose L. Corchado-Albelo

Tellurium (Te), a critical mineral for solar energy technologies, faces supply risk challenges that drive the development of diversified and robust production routes. This research focused on improving Te enrichment from copper tailings (CT) produced from copper porphyry (CP) ores processing, addressing the loss of ~90% of Te minerals to tailings in the flotation process of CP ores. Gravity separation and froth flotation processes were used as possible enrichment routes of Te-bearing minerals (i.e., pyrite) in CT. In the froth flotation process, synergistic combinations of reagents were tested to achieve an acceptable enrichment ratio of Te minerals. Comprehensive characterization analyses showed significant Te enrichment in the flotation concentrates. Tellurium was recovered at 90%, while the grade of Te in the concentrates was 1.4 ppm using a xanthate collector and glycol frother compared to <0.5 ppm in the flotation feed. Findings showed that Te-minerals’ enrichment was also feasible in CT using the proposed combined concentrations routes (i.e., gravity separation followed by froth flotation) by looking at Fe, Cu, and S enrichment. This study also highlighted the importance of understanding the deportment of Te minerals in different process streams to develop and optimize efficient enrichment practices.

Feb 1, 2024

By D. R. Mathews

Electrorefined vanadium was evaluated with respect to tensile properties and the effects of interstitial contaminants in the temperature range of 77° to 273° K. The yield strength of 18,500 psi and hardness of 63 diamond pyra-mid hardness (DPH) of electrorefined vanadium are approximately equal to that of iodide crystal bar vanadium. The ductile-brittle transition temperature was found to be below 77° K, but with 0.175 weight-percent oxygen or 0.10 weight-percent nitrogen, it increased to between 123° and 190° K. With carbon content up to 0.11 weight-percent, the transition temperature remained below 77° K. The yield strength of the interstitial-containing alloys can be expressed by: au = 7.5 + 480 (pct N) + 290 (pct 0) + 280 (pct C), where au is the upper yield stress in 1,000 psi at 273° K. Profuse deformation twinning occurred in the alloys tested at 77° K. However, twinning could be suppressed by dissolved oxygen or nitrogen in excess of 0.15 and 0.086 weight-percent, respectively. Carbon, even though present in excess of the solubility limit, did not affect twinning.

Jan 1, 1965

By D. M. Lewis, J. K. H. Ma, Y. Rojanasakul, J. Y. C. Ma, J. H. Kang, V. Castronova

"Tetrandrine is a bisbenzylisoquinoline alkaloid which has been shown to exhibit antifibrotic activity against silicosis. Tetrandrine is characterized by its strong binding to alveolar macrophages and inhibition of particle-induced respiratory burst activity in these phagocytes. In contrast, tubocurine and tubocurarine are structurally similar to tetrandrine but exhibit little effect on fibrosis or activation of alveolar macrophages. The objective of the present study was to test the effect of tetrandrine on macrophage production of monokines in response to occupational dusts, and to determine tetrandrine's effect on monokine-medicated cell growth using a mouse thymocyte proliferation assay and lipopolysaccharide (LPS) as a positive control. Stimulation of alveolar macrophages by respirable silica dust resulted in a release of monokines which caused a fourfold increase in thymocyte proliferation. Coal dust, on the other hand, had no effect on macrophage production of this cytokine. Tetrandrine was found to exhibit a dose-dependent inhibition of monokine release from both silica and LPS-stimulated alveolar macrophages. In experiments where thymocytes were directly treated with tetrandrine, a dose-dependent inhibition of thymocyte proliferation was noted with both interleukin-1- (IL-1) specific and nonspecific mitogenic (concanavalin A) actions. In contrast to the inhibitory potency of tetrandrine, tubocurarine was found to have no effect on either the production of monokines by LPS-stimulated alveolar macrophages or IL-I-mediated thymocyte proliferation. These results provide a correlation between the ant:fibrotic effect of tetrandrine and inhibition of macrophage activation. INTRODUCTIONThe pathogenesis of chronic pulmonary fibrosis caused by inhalation of occupational dusts has been associated with abnormal activation of alveolar macrophages such as the release of various cytokines capable of inducing fibroblast proliferation and collagen synthesis. These macrophage-derived cytokines include interleukin-1 (IL-1), tumor necrosis factor (TNF), platelet-derived growth factor (PDGF), transforming growth factor-B (TGF-(B), macrophage derived growth factor (MDGF), and interferon [1, 2].Interleukin-1 is a major macrophage-derived cytokine that has been shown to exhibit multiple biological effects on a variety of target cells. It is known to cause leukocyte [3, 4] and endothelial cell activation [5, 6], and to affect the synthesis and maintenance of the extracellular matrix by stimulation of fibroblast proliferation [7-9], synthesis of collagens [10] and gluco-saminoglycans [11], and prostaglandin E2 production [12]. In addition, IL-1 plays an important role in the initiation of an immune response through its direct activation of lymphocytes and stimulation of the production of other cytokines, such as interferons and hemopoietic colony-stimulating factors, needed for the expression of an immune response [13]. As a major cytokine in the immune-inflammatory sequela, IL-1 is also produced by epidermal, epithelial, lymphoid, and vascular tissues after infection, injury, or antigenic challenge [14]. Agents such as lipopolysaccharide (LPS), phorbol myristate acetate (PMA), immune complexes, and particulates are known to activate the synthesis and release of IL-1 by monocytes and macrophages [15]. These substances also trigger intracellular signals leading to altered arachidonic acid metabolism. Although the mechanism is still not clear, prostaglandins have been shown to suppress IL-1 translation via the induction of cyclic adenosine-monophosphate (CAMP), whereas leukotrienes produce a positive signal for IL-1 production [13]."

Mar 1, 1992