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By Masaji Kato, Yuusaku Tominaga

To maintain good condition of ventilation for both safety and economy, many regulators are installed in a network. In case the open state of a regulator is different from the set point, identification of a broken regulator and a countermeasure to recover airflow distribution in a network must be initiated as soon as possible. An experienced mining engineer can sense a deviation from ordinary airflow quantity. In this paper, a new system to monitor all the regulators in a network is introduced. The basic concept of the system is utilization of both human sensing of airflow rate and computer simulation to understand the macroscopic characteristics of a ventilation network. A fuzzy pattern distinction method is used to process human determination of airflow rate that may be ambiguous. The applicability of the system is demonstrated using the ventilation network of the Horonai coal mine, Japan. In particular, it is shown that the system can identify the regulator to be repaired from information supplied by workers relating to air- flow in a few sensor branches.

Jan 1, 1997

By C. Brown, N. Rayyan, T. H. Dubaniewicz

Lithium-Ion batteries (LIBs) have the potential to go into thermal runaway which introduces a new ignition source in hazardous environments such as gassy underground mines that may contain methane in the surrounding air. Researchers from the National Institute for Occupational Safety and Health (NIOSH) used an accelerating rate calorimeter (ARC) to induce thermal runaway in individual lithium-titanium-oxide (LTO) and lithium-nickel-cobalt-aluminum-oxide (NCA) LIB cells within a sealed enclosure with either no methane, a lean, a stoichiometric, or a rich methane-air mixture in the surrounding canister to determine if these LIB types would ignite the methane, causing an additive effect on overpressures. Canister pressures and maximum temperatures reached by the cells, surrounding air, and exhausted gases were measured in this study and remained consistent with varying methane concentrations.

Feb 1, 2023

By C. RAMADINI, F. NURJAMAN, A. SHOFI, B. SUHARNO

Nickel demand is increasing along with the rising need for stainless steel and other alloy steel/iron. The small addition of nickel in such materials can improve impact strength, ductility and corrosion resistance. Nickel is generally obtained from nickel sulfide ores (nickel associated with sulfur) and nickel laterite ores (nickel associated with iron and magnesium silicate). Almost 60 percent of nickel is now produced from sulfide ores, despite its existence in sulfide ores being less than in laterite ores. However, the depletion of sulfide ore reserves makes the mastery of nickel laterite ore processing of important and immediate concern. Selective reduction followed by magnetic separation has been in development in lateritic nickel ore processing to overcome the issues of high energy consumption and pollution associated with conventional pyrometallurgy methods such as blast furnace and rotary kiln electric arc furnace (RKEF).

By Dan Martz, Stuart Lipofsky, Dean Workman

"The Indianapolis Deep Rock Tunnel Connector (DRTC)—first in a vast network of storm water storage tunnels below Indiana, USA—was a wildly successful endeavor. Crews for the Shea/Kiewit JV drove a 6.2 m Robbins Main Beam TBM to world record rates. The machine achieved 124.9 m/day, 515.1 m/week, and 1,754 m/month in limestone and dolomite rock. The advance rates can be attributed to many factors including ground conditions and knowledgeable crew, but continuous conveyors are also of key importance. The novel conveyor system, manufactured by The Robbins Company, enabled continuous tunneling in a difficult layout that included two 90-degree curves and two S-curves. Spanning 11,777 m in its longest iteration, the system included nine booster drives plus a main drive. A vertical belt moved muck up the 76 m deep shaft to a radial stacker for temporary storage. The system, one of the most complex in North America and the first to operate in 90-degree curves, made swift tunneling possible. This paper will examine the world-class tunneling done at the Indianapolis DRTC and the role of continuous conveyance in reaching high advance rates. The logistics of the system will also be examined as it could apply to future tunneling projects with similarly complex layouts. INTRODUCTION The Indianapolis Deep Rock Tunnel Connector (DRTC) is the first phase of a nearly 28-mile long network of deep rock tunnels being built 76 m beneath the City of Indianapolis, Indiana by Citizens Energy Group. The Deep Rock Tunnel Connector (DRTC) Project is a 12.2 km, 5.5 m diameter tunnel constructed by S-K JV, a joint venture between J.F. Shea Construction and Kiewit Infrastructure Co. The tunnel is a $179 million project and is the first segment and southernmost portion of a deep, large diameter conveyance and storage tunnel system to provide overflow relief during wet weather events. The project is estimated to be completed in 2017 and will initially deliver 204,000 cubic meters of the planned 1 million cubic meters of CSO storage for treatment, as well as provide future connections to other tunnels in the overall system (see Figure 1)."

Jan 1, 2016

By Ruipeng Qian, Pengfei Wang, Guorui Feng, XianJie Du, Jun Guo, Yuxia Guo, Tingye Qi, JinWen Bai

"A numerical modeling was conducted to describe the behavior of overlying strata on the longwall top coal caving face for exploitation of a 16.8 m thick coal seam. Three typical structural models, including the Cantilever Structure (CS), Lower Cantilever and Upper Hinged Arch Structure (LC&UHA), and Lower Arch and Upper Voussoir Beam (LA&UVB), were developed. Based on mechanical analysis of the different structures of the key strata, and considering the behaviors of the broken igneous rock strata, a method was proposed and applied to estimate the structures of the overburden strata. The results had been verified by a field micro-seismic monitoring test. The paper provides a foundational method to determine the shield loadings for the top coal caving longwall face.INTRODUCTIONLongwall top coal caving (LTCC) is a highly productive underground mining technology which has been widely applied to the exploitation of the thick coal seams in China and other countries due to its high efficiency (Ju and Xu, 2013; Ju, Xu, and Wang, 2011; Liu et al., 2009). In recent years, a large amount of research on mining pressure forecast, strata control, and mechanical equipment improvement of the LTCC technology has been carried out, which greatly advances the field application of the technology (Liu et al., 2009; Yu, 2016; Dou et al., 2014; Feng et al., 2011; Chen and Li, 2011; Yin, Yan, and An, 2008). In 2006, the LTCC technology was first applied to the exploitation in a 20 m thick coal seam at the Tashan Coal Mine in China (Yan et al., 2011). Ten years of mining at the Tashan Coal Mine has highlighted the importance of the support management in controlling the roof strata on the extra-thick LTCC face. The mining pressure is closely related to the structural features of the overlying strata and its movement laws (Yu, 2016; Dou et al., 2014; Feng et al., 2011). However, the distributions of three zones—caving zone, fracture zone, and deformation zone—on the fully mechanized caving longwalls changed significantly with the increase in thickness of the coal seam (Chen and Li, 2011). The behavior changes of the roof strata led to abnormal pressure in the mining face and resulted in the difficulty of surrounding rock control (Yin, Yan, and An, 2008; Liu et al., 2009; Yan et al., 2011; Gong and Jin, 2008). Therefore, the theoretical research focused on the behavior of overlying strata to reveal the laws of mining pressure has important theoretical significance and practical value.Many classical studies (Qian and Shi, 2003; Feng, 2010; Yu, 2015; Yu, Yan, and Liu, 2012) had been done to describe the behavior of overlying strata in the mining process. It has also been reported that magma intrusion causes an important effect on the surrounding rock, coal, and methane (Wang et al., 2005; Liu et al., 2007). On the one hand, the property and structure of the coal seam was obviously changed by the magma intrusion and resulted in a potential danger of a gas outburst during the mining process (Chen et al., 2012; Wang et al., 2014). On the other hand, the hard igneous strata and the joints occurred with the magma cooled, causing an abnormal behavior of overlying strata and resulting in a series of dynamic disasters during mining (Xuan, Xu, and Lu, 2014; Lu et al., 2016). In fact, many coal fields in China are intruded by igneous sill, including the Datong, Shuozhou, Huainan, and Xuzhou coal fields (Chen et al., 2014; Wu, 2011). The 3–5 coal seam at Tashan Coal Mine in Datong coal field is very thick and is intruded by a large area of layered lamprophyre rock. Face falls and shield failures occurred frequently during the face retreat."

Jan 1, 2019

By R. P. Proulx

The Meikle Mine is a high grade, underground goldmine utilizing primary-secondary longhole open stoping with delayed backfill to produce 2700 tpd(3000 stpd) of ore. Hot and reactive ground conditions were encountered early on in the mine life. Ground temperatures up to 166°C (330°F) were measured. In the early stages of mining, the mine experienced premature detonations using different explosive products. The learning curve to safely mine this high-grade gold deposit in hot and severely reactive ground was indeed very steep. Currently, the Meikle Mine uses a special buffered bulk emulsion in all blasts to address hot and reactive ground concerns. In addition, exacting procedures are also followed to ensure safe work with explosives. The combination of new explosives technology and strict loading procedures permits high mine productivity with the highest degree of safety.

Jan 1, 2000

By Ihsan Berk Tulu, Mark Alexander Van Dyke, Deniz Tuncay, Ted M. Klemetti

Bleeder entries are critically important to longwall mining for the moving of supplies, personnel, and the dilution of mine air contaminants. By design, these entries must stay open for many years for ventilation. Standing supports in moderate cover bleeder entries were observed, numerically modeled, and instrumented by researchers at the National Institute for Occupational Safety and Health (NIOSH). The measurements of the installed borehole pressure cells (BPCs), standing support load cells and convergence meters, and roof extensometers are presented in this paper in addition to the numerical modeling results and visual observations made by the NIOSH researchers in the bleeder entries. The results include the effects of multiple panels being extracted in close proximity to the instrumented site as well as over one and a half years of aging. As expected, standing supports closer to the longwall gob showed the greatest load and convergence. The roof sag appeared generally independent of the proximity to the longwall gob. The BPC readings were driven by both the proximity to the gob and the depth into the pillar. The results of this study demonstrated that the entry roof can respond independently of the pillar and standing support loading. In addition, the rear abutment stress experienced by this bleeder entry design was minimal. The closer the mine development, pillar, or supports are to the gob, the greater the applied load due to rear abutment stress.

Jan 7, 2021

By Reynold Q. Shotts

One often sees in the papers, in these days of ecological consciousness, estimates of the quantity of land that has been "devasted," "ruined," or "destroyed," by surface or strip mining, especially for coal. One feels sure that coal miners must have been the first to discover the art of excavation and that the public didn't know of its existance until five or 10 years ago! Estimates of the acreage vary widely with most of them sounding somewhat unreal. One estimate of 175,000 acres in Alabama appeared in one newspaper article and the implication was that all of this was mining for coal. The question was raised anew last summer when the author began working on a land use estimate utilizing aerial photographs, a preliminary project to the Alabama Earth Resources Technology Satellite (ERTS) contract presently being fulfilled. One land use category was barren or waste land and aside from some sand beaches in the two coastal counties in Alabama, recently strip mined land constituted most of that category. It quickly became apparent that old stripping was very hard to detect so that estimates from aerial photographs are not accurate. With regard to relatively new stripping, a thin veneer of reflective dirt washed over the countryside may result in a considerable overestimate of the excavated area. Actually, there is a way to estimate the area excavated by strip mining using published Bureau of Mines figures. At least three sets of data are needed: (1) Coal production figures, (2) average thickness of coalbeds mined, and (3) an accurate recovery figure.

Jan 1, 1973

By Xuehui Li, Xinshuai Shi, Jun Wang, Jianguo Ning, Shang Yang, Zhaohui Zhang

Pressure relief is an important step in preventing and controlling rock burst disasters. Hydraulic slotting has emerged as a strategy for pressure relief and energy release in roadway surrounding rock. There is no qualitative description for the response relationship between hydraulic slotting parameters and the degree of pressure and energy release in a roadway, which is a scientific problem. In this paper, theoretical analysis, numerical simulation, and on-site industrial practice were comprehensively used. First, a structural model for the pressure relief and energy release of coal by hydraulic slotting in a deep roadway was established, and the pressure relief and energy release principle by hydraulic slotting was revealed. The principles and methods for determining hydraulic slotting parameters in the roadway were proposed. Three evaluation indices for the pressure relief and energy release effect of coal after hydraulic slotting were proposed, namely, the stress ratio of coal, elastic energy density ratio of coal, and displacement rate of the roadway rib. According to the evaluation indices, the degree of pressure relief and energy release was divided into three levels: reverse pressurization, full pressure relief, and transitional pressure relief. Then, a FLAC3D numerical model was constructed, the levels of pressure relief and energy release under different hydraulic slotting parameters were analyzed, and the optimal slotting parameters were determined. Finally, on-site industrial practices were carried out in Panel 7312 of the Xinhe Coal Mine. An effect test showed that the effect of pressure relief and energy release was remarkable after hydraulic slotting was adopted on the roadway surrounding rock, which can effectively reduce the risk of rock bursts. These research results can further improve hydraulic slotting technology systems and provide a theoretical basis and technical reference for the stability control of deep roadway surrounding rock.

Sep 20, 2023

By James J. Broderick

In the production of Pig Iron - Limestone, Coke and Iron Ore pellets are changed to the blast furnace and reacted at approximately 2,800 degrees F. The resultant products are molten iron and a molten slag - not unlike lava. The molten slag stream is channeled into open pits, cooled with water, crushed and sized for various industrial applications. The production of steel from pig iron in open hearth, B0P, BOF and electric furnaces results in somewhat similar slags: but since free lime is normally the flux, the resultant slags are not satisfactory for use in cement pastes. When exposed to water, the lime slakes, expands by 250% and ruptures the concrete. Thus, the slag discussed first is Blast Furnace Slag composed of 30 to 40% Silica (SiO2) Alumina (AL202) 7 to 16% Lime (CaO) 32 to 45% and Magnesia (MgO) 5 to 15%. The oxides do not exist as free oxides but rather as silicates and alumino silicates which are chemicall inert. Since transportation costs limit the area of use, blast furnace slag can only be found in concrete products produced within 60 to 100 miles of a blast furnace operation. Even within these areas where slag is in heavy supply, quite often the use of slag is minimal for concrete aggregate and the major outlet is road base.

Jan 1, 1985

By SAHENDRA SINGH, SANJIT KUMAR PAL, DHARMITA HORO

This study was carried out in Ichadih to map the sulfide/gold mineralization using combined electrical resistivity tomography (ERT) and self-potential (SP) methods. No geophysical analysis has been carried out to delineate such ore deposits in the area. Thus, the study provides a different approach for approximate location and extension of the quartz reef associated with sulfide/gold mineralization. It also provides the elementary idea for further detailed subsurface investigation in terms of geological and geophysical approach. 

By A. D. Davis

This project took a watershed approach in the evaluation of water-quality impacts from past mining activities and current restoration projects in the Bear Butte Creek basin, a small and well defined drainage in a heavily mineralized area of the northern Black Hills. The basin contains numerous inactive and abandoned mines as well as a currently active heap-leach surface gold mine. Bear Butte Creek normally loses all of its discharge to sinkholes in the Madison Limestone aquifer and thus can affect the water quality of this regionally important water resource. Water-quality data were analyzed, stream surveys were conducted, and two abandoned mine restoration projects were monitored to evaluate the effectiveness of the watershed approach and to identify practical remediation techniques that could be applied to other watersheds. A geographic information system (GIS) was developed to organize information on stream quality, abandoned mine locations, and other geologic and hydrologic data. The watershed approach toward assessing and reclaiming abandoned mines appears to be effective when compared to a point-source approach that might improve water quality at specific sites but not result in significant overall improvement to the watershed because of adjacent sources.

Jan 1, 1997

By William P. Diamond

Production trends have been analyzed for 82 gob gas ventholes on 7 longwall panels in the Lower Kittanning Coalbed, Pennsylvania. Cumulative production from individual holes was found to vary considerably, ranging from 0.03 x 106 m' to 10.1 x 106 m3. Peak production rates were generally about 0.03 to 0.06 x 106 &/d, but rates over 0.10 x 106 m3/d were observed. The variability of gas production from individual holes can be attributed to several factors including: completion practices and problems, the extent of fracture development in the strata above the extracted panel, water production, and location on the panel. Of particular significance, is hole location. Holes on the ends of the panels, where overburden strata are in tension due to the support of the surrounding pillars, were generally the highest and longest producers. This observation led to the experimental placement of gob gas ventholes in the zone of tension along the margin of a panel, instead of in the traditional centerline location which is in compression. Analysis of gob gas production data indicates that the experimental near-margin holes produced 77 pct more gas than did centerline holes on the same panel.

Jan 1, 1995

By J. S. Walker

Public Law 95-87 enacted by Congress in 1977 and subsequent regulations require coal mine operators to predict the effects of mining on the environment prior to the start of mining. Prediction of the effects of mining on the local groundwater system is a difficult task due to its complex nature and the lack of detailed published information. An investigation of water level fluctuations in five we1 1s positioned over three consecutively mined longwall panels was initiated in conjunction with an intensive subsidence monitoring program. The purpose of this work was to provide detailed information which could be used to predict certain hydrologic effects of longwall mining in the Northern Appalachian Coal Region. The results of this case study indicate that water level fluct- uations in the local ground-water system above longwall panels is associated with subsidence and that the static water level will generally re- establish at or near the pre-mining elevation after mining is completed.

Jan 1, 1986

By Thomas M. Tharp, Mark A. Travers

A new method is presented for precracking three-point bending specimens for fracture toughness testing. A notched specimen of rectangular cross section is placed on a flat loading platen, with paper between specimen and platen. The specimen is loaded from above through a roller placed directly over the crack. The thin, high compliance joint between specimen and platen causes a distributed load on the bottom of the specimen. This results in bending at the cracked section and crack initiation at the notch tip. Since the joint is thin, its stiffness increases rapidly with deflection and crack propagation in the specimen generally remains stable and controllable. Fracture toughness KIC in a sandstone directly overlying the No. V coal was measured to be 0.27 MPa m 1/2. Even for cracks 1 cm long this value of KIC results in substantially lower effective tensile strength (modulus of rupture) in roof beams than is expected from intact rock strength.

Jan 1, 1986

The management of risks associated with slope instability is an essential process in the safe and economic operation of open cut mines. The ?slope stability radar? (SSR) has been developed to better manage those risks. The SSR remotely scans rock slopes to continuously measure any surface movement and can be used to detect and alert users of wall movements with sub-millimeter precision. The high level of movement precision and broad area coverage of the rock face can allow for a better understanding of the geomechanics of slope deformation, including magnitude of potential failures and additional warning time of impending instability. Additionally, radar waves adequately penetrate through rain, dust and smoke to give reliable measurements, 24 hours a day. SSR systems have been deployed in many metalliferous and coal mines throughout the world. Over 80 systems are currently being used with current operations in 17 countries. Greater than 200 rock slope collapses and waste dump failures (from several to millions of tones) have been monitored, with ?warning? precursor movements recorded by the SSR. This technology enables a radical change in the management of risks in open cut mining. This paper will present recent case studies of the SSR operation in coal and metalliferous mines. Slope Stability Hazards and Rock Slope Monitoring in Open Pit Mines Surface mining often creates excavation boundaries which are steeper than those would be created under natural processes in the same rock type. They are also undertake quite rapid stress changes during mining and are influenced by significant external forces such as blast vibrations and changes in groundwater. These conditions are likely to allow some degree of instability to develop in the pit slopes. The hazards associated with this instability of pit slopes can be extremely variable in character; ranging from small cobble sized rocks dislodging and falling from mine benches to complete collapse of entire pit walls. It is usually the position of mine geotechnical or geological staff to assess these hazards for mine operations. The assessment of hazards due to unstable slopes can be done by visual observation of precursor signs such as fracturing or rilling of loose material. A more reliable indicator of instability involves the quantitative measurement of outward movement and acceleration of material as an instability mechanism develops. There is strong evidence that small precursor movements of a rock wall occur for an extended period prior to rock slope collapse (Hoek and Bray, 1981). Development of a monitoring system, adopting acceptable slope deformation criteria coupled with warning systems and design of stabilization or risk reduction measures if appropriate has become a standard method of dealing with slope instability. Framework for Slope Hazard Management using the SSR A framework for the management of slope hazards is shown in Figure 1 (discussed in detail in Harries, 2007). Although this framework is specifically for use with the Slope Stability Radar, a similar framework could be developed for other monitoring technologies for monitoring slope deformation. An important point to consider is the sequential nature of the hazard management framework from selecting the context ? identifying hazards ? analysing hazards ? evaluating hazards ? treating hazards. [ ] Once the context of the system has been developed (for example ? to monitor for rapid bench scale collapse), the identification of hazards is the next stage in hazard management. Identification of slope hazards can be relatively straightforward due to the visual nature of the information that the SSR system produces. The areas of excessive wall deformation are highlighted in color maps of the mine slope with a co-aligned photographic image to review the actual site of interest. The responsible personnel must then analyses this data, usually reviewing the deformation style and rate, as well as the size of area that appears to be failing. This information can then be evaluated against organisation protocols (for example it may be only a small sub-bench failure that will be ?caught? by existing benches and hence can be categorized as a lower risk). Once these hazards are evaluated they can then be treated if required. Two major options are available to reduce the risk during this treatment option. We can reduce the likelihood of failure ? for example by buttressing the failure or de-pressurising of water pressures in a slope. However, the most likely plan of action is to reduce the consequence of the failure. One of the most successful opportunities to reduce the consequence of a slope failure is to ensure that no personnel or mining equipment is present at the location of a slope failure when collapse finally occurs. This has been the major benefit of the SSR system to the different mining operations around the world. SLOPE STABILITY RADAR TECHNOLOGY OUTLINE Slope Stability Radar system specifications and capabilities: ? Measurement precision +/- 0.1mm (std.) ? Perforated dish and other features enable it to operate in high wind conditions ? Measurement range is 1700 metres ? Scans 270 degrees horizontally and 120 degrees vertically ? 1 ? 30 minute repeat rate for area scans (varies according to area being scanned ? RF exposure (<0.05mW/cm2) is a factor of 200 below the acceptable limit for the general population (1 mW/cm2) ? Tolerant to vibration and mining equipment ? The system weighs approximately 1500 Kg ? Remote area power supply enabling unmanned, continuous 24/7 monitoring ? Real time monitoring

Jan 1, 2009

Anhydrite-based dam constructions, which have been implemented successfully in other geological formations, were investigated with regard to their suitability in salt mines. The laboratory investigations show that anhydrite-based building materials with suitable additives bind safely in spite of the high temperatures in salt mines which normally pre-vent hydration. The dependence of the compressive strength, swelling behavior, porosity and permeability upon the choice and ratio of binding material components and additives was determined. Based on the results of these investigations, a pilot-scale experiment was carried out at the GSF Research Mine Asse (Germany) using a mixture suitable for the prevailing conditions

Jan 1, 2004

By Weijie Wei, Jinwang Zhang, Shengli Yang

Due to the unbalanced top coal drawing process, the recovery ratio is low, and the equipment stability is poor in the longwall top coal caving mining (LTCC) with an inclined seam. Aimed at these problems, this paper proposes the dynamic group caving method (DGCM). The basic procedure is that when the drawn volume of top coal from a support reaches about half, the next support begins drawing top coal, and the drawing process between the two supports is half done. Taking the panel no. 8103 in Beixinyao mine as the research object, the characteristics of drawing body shape, particle movement trace, and variation of recovery ratio are investigated by using Particle Flow Code. Furthermore, the effect of mining-caving ratio on the top coal drawing law under DGCM is revealed by the simulation results, and compared with the single-opening sequence caving method (SSCM) and the doubleopenings sequence caving method, advantages of DGCM are determined in inclined seams. The results show that the drawing body can be divided into the left and the right under DGCM. Specifically, the drawn top coal particles in the left are from the upper part of this support, that in the right are from the lower part of next support, which verifies the correctness of the theoretical analysis. The characteristics of the drawing body shape are more significant when the mining-caving ratio is relatively small. In addition, with increasing mining-caving ratio, the recovery ratio of the panel both increases gradually underDGCMand SSCM.When the miningcaving ratio is less than 1:1, the recovery ratio of DGCM is obviously higher than that of SSCM, indicating that DGCM can greatly improve the recovery ratio. While when the mining-caving ratio is larger than 1:1, the recovery ratio of two caving methods is basically equal; however, the advancing time is significantly shortened under DGCM. This study are of great significance to realize high efficiency and precise caving in LTCC with an inclined seam.

Jul 7, 2020

By Ora H. Rostad

Some gold production was obtained from placer deposits in Puerto Rico during the period of Spanish colonial rule, but most of the gold was produced prior to 1536. There had been no significant hard rock mining, other than in quarries for road metal or construction purposes or for raw materials to make cement, prior to 1954 when the government of the Commonwealth of Puerto Rico recognized that changes in the mining code were necessary to stimulate exploration for metalliferous ore deposits. The Puerto Rican Legislature passed an act (No. 6), which was approved on Oct. 6, 1954, that reiterated that the title to all "commercial minerals" is vested in the Commonwealth of Puerto Rico. The act provided for the establishment of a Mining Commission, stipulated the power% with which the Mining Commission was vested, and provided that no one may dispose of "commercial minerals" in Puerto Rico without a Commonwealth grant issued on its behalf by the Mining Commission. Act No. 6 also provided for prospecting permits, mining leases, and grants. The Mining Commission, by authority granted to it by Act No. 6, adopted regulations effective Nov. 21, 1957, relating to prospecting, leasing, and producing commercial minerals in Puerto Rico. Royalty rates were also specified for various types of deposits at different annual tonnage production levels.

Jan 1, 1991

By Vincent Castronova, Jane Y. C. Ma, Joseph K. H. Ma, Chang-geng Mo, Carl J. Malanga

A group of bisbenzylisoquinoline (BBIQ) alkaloids has been shown to exhibit various degrees of effectiveness in preventing silicainduced fibrosis in animal models (1, 2). The capability of these drugs to interact with phosphatidycholine vesicles and rat alveolar macrophages was studied using fluorometric and equilibrium dialysis methods. The lipid binding affinity of these alkaloids was found to depend upon several structural factors including hydrophobic substitutions, the chiral configurations, and the double oxygen bridge-restricted conformation of the benzylisoquinoline moieties. Tetrandrine, which is highly effective in preventing fibrosis, showed strong binding to both lipid vesicles and alveolar macrophages. In contrast, curine and tubocurine, which have little or no effect on silicosis, exhibited only weak binding to lipid vesicles and almost no binding to cells. The moderate binding affinity of fangchinoline to vesicles and cells corresponded to a moderate effectiveness of the compound as an antifibrogenic agent. Methoxyadiantifoline, an alkaloid of unknown antifibrogenic potential, also exhibited high binding affinities for lipid and cells. In summary, this study indicates that alveolar macrophages exhibit large binding capacities for certain members of the BBIQ alkaloids. A positive correlation was observed between binding affinity to alveolar macrophages and the reported antifibrotic potency of these compounds, suggesting that the ability of these drugs to interact with alveolar macrophages may be a key step in inhibition of the progression of silica-induced pulmonary disease.

Jan 1, 1991