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By P. R. Miles, J. K. H. Ma, J. Y. C. Ma, L. Bowman

"The bisbenzylisoquinoline alkaloids are compounds which can be isolated from plants and which exhibit a broad range of pharmacological activities. Perhaps the best known alkaloid of this group is tetrandrine (TT), a compound isolated from the root of a traditional Chinese medicinal herb, Stephania tetrandra. It has been tested for its effects on the cardiovascular system, tumors, and the lungs. For example, tetrandrine has been shown to act as a calcium entry blocker in cardiac sarcolemmal vesicles (King et a/., 1988) and has been used in China as a treatment for angina and hypertension. Its possible effects as a tumor-inhibitory substance have also been investigated (Kupchan and Atland, 1973). In addition, there are several lines of evidence to suggest that it is a possible therapeutic agent for the treatment of silicosis. Yu et a/. (1983) have shown that TT inhibits the development of experimental silicosis in rats when it is administered orally after intratracheal instillation of quartz. Other studies have shown that the alkaloid inhibits the synthesis of collagen by fibroblasts and the formation of silicotic nodules in rats exposed to silica (Huang et al., 1981; Liu et al., 1983). In fact, tetrandrine has been used clinically in China as an antifibrotic agent and has been shown to improve both the appearance of chest radiographs and the measurements of diffusing capacity in patients with silicosis (Li et al., 1981).Since tetrandrine may have a potential use as a therapeutic agent for fibrotic lung diseases, its effects on various pulmonary cells and tissues should be studied. Alveolar type II cells are located in the alveolar regions of the lungs and are important because they are responsible for the synthesis and secretion of pulmonary surfactant (Dobbs et al., 1982; King, 1984), regeneration of the alveolar epithelium after lung injury (Kauffman et al., 1974), and metabolism of foreign compounds (Bend et al., 1985). Furthermore, in silicosis, for which TT has been suggested as a treatment, there are increased amounts of pulmonary surfactant produced (Dethloff et al., 1986a,b) as a result of increased rates of surfactant synthesis by type II cells (Dethloff et a/., 1989; Miller et al., 1988). Because type II cells play a critical role in maintaining normal lung function and because type II cells are affected in silicosis, for which 'TT has been used as a treatment, we studied the effects of tetrandrine on energy metabolism in these cells in vitro. Energy metabolism was chosen because it is a basic cellular function which is neces-sary for other cellular processes to occur. Since type II cells depend on mitochondrial metabolism for energy production (Fisher et al., 1980), we examined the effects of tetrandrine on cellular and mitochondrial ATP production and oxygen consumption. Additional experiments were performed in an effort to determine if intracellular calcium levels may be involved in the TT-induced effects. A preliminary report of those results has appeared previously (Ma et al., 1991)."

Nov 1, 1995

By C. B. Carelse, M. Manuel, D. Chetty

Automated mineralogical analysis of platinum group minerals (PGM), using the mineral liberation analyser, provides information used to understand flotation efficiency, primarily from a PGM liberation and association standpoint. To date, however, there is no consistent understanding regarding PGM speciation and its impact on floatability. Previous studies of PGM from UG2 ores concluded that a larger dataset is needed from which the various parameters can be modelled. Parameters on telluride, arsenide, sulfurarsenide and alloy species need to be integrated to fully understand the impact of PGM speciation on flotation, and for this, ores other than PGE-sulfide-rich UG2 must be assessed. Flotation rougher rate tests were performed on feed samples from two Platreef ores to determine the flotation response of individual liberated PGM species. This was achieved through automated mineralogical analysis of feed, rougher concentrates and tails. Based on 1529 liberated PGM grains assessed over the circuit for two Platreef ores, preliminary results show that PGM speciation, species grain size and competition from gangue appear to influence floatability in an ‘optimised’ laboratory environment. Keywords: PGM, PGM species, flotation, liberation

Jan 1, 2020

By A Flatten, F Reusch

Recent advances in the disciplines involved in simulating large mining operations provide increasingly precise and accurate methods for the study of cave mechanics; however, in large regional-scale models, hydrological aspects are often neglected or studied independently from the mechanical problem. There exists a great demand for a unified approach to study and simulate both the mechanical and hydrological phenomena that allows for a more detailed understanding of the effects of groundwater flow, dewatering and the impact on block cave mining operations.This paper presents a numerical framework that combines three-dimensional regional-scale hydrological simulation techniques for groundwater flow, together with non-linear continuum–discontinuum rock mechanics models, provides such a unified modelling approach. The underlying simulation technique is based on a coupled parallel solution formulation adopting single-phase fluid flow formulations into a discontinuous, strain softening and dilatant finite element model. This approach is adopted for the presented case study of a realistic block caving example in a simplified unidirectional coupling formulation, to investigate the effects of the mechanical analysis on the hydrological response. Here, particular emphasis is on the non-linear coupling of the deformable and strain-softening solid skeleton and fluid phase; eg the change of hydraulic properties with evolution of damage in the rock mass and large-to-intermediate scale structures due to ongoing caving operations. The importance of discontinuum structures is discussed, as mining-induced fault reactivation significantly influences the hydrological response.CITATION:Flatten, A, Reusch, F and Beck, D, 2016. The application of hydromechanical mine-scale modelling for large block caving operations, in Proceedings Seventh International Conference and Exhibition on Mass Mining (MassMin 2016), pp 341–348 (The Australasian Institute of Mining and Metallurgy: Melbourne).

May 9, 2016

By G. X. Du

Reaction kinetics of serpentine and hydrochloric acid is theoretical basis for optimizing reaction process conditions of serpentine and hydrochloric acid. Kinetics of serpentine and hydrochloric acid was studied in this paper. The results indicated that apparent reaction order to hydrochloric acid was two and reaction kinetic equation could be expressed as: 2HClHCl,ddtckct-=·. The diffusion rates of hydrogen ions in liquid film on surface of serpentine particle and in amorphous silica layer generated in the reaction and chemical reaction velocity during the reaction had important effects on to-tal reaction velocity. And chemical reaction velocity had the most significant influence. The relation of conversion rate of magnesia xMgO with reaction time could be expressed as: 1(1)xkt--=·.

Jan 1, 2014

By William K. Brown

Are the results of an exploration program worth the cost? This is a question I suspect many of you are familiar with and, theoretically at least, it is an easy question to answer. The answer, of course, lies in comparing the future earnings stream the program is expected to generate, to the present value of the cost of carrying it out. While historical costs can be determined without much difficulty, estimating the value of a future earnings stream involves all sorts of assumptions regarding future costs, metal prices, inflation rates and an appropriate discount factor; and in the context in which the question arises, requires additional assumptions about mineral deposits which have yet to be discovered. As a practical matter, this kind of approach isn't likely to produce a very convincing answer; certainly not one convincing enough to satisfy a skeptical audience; nor one likely to temper the illusions of recent converts to mineral exploration, who are convinced that if enough money is spent, profitable discoveries will inevitably follow. Within broad limits, however, I believe it is possible to analyze the costs and results of gold exploration in the U.S.A. over the past 20 odd years in a useful manner. And while such an analysis is imperfect, it will provide some insight into this fascinating subject.

Jan 1, 1983

By R. A. Wyman

A comparison of the amount of minus-28-mesh product produced by a standard grinding test procedure is provided for 45 non-metallic materials. The percentage of product, the weight of product per unit of energy used and the weight of product per mill revolution are shown. The results exhibited excellent reproducibility and demonstrated an accurate comparison of grindability for non-metallic materials.

Jan 1, 1977

By J. A. Herdlick

"INTRODUCTION The Bureau of Mines began a broad program of exploration of various proportion in the Pine Creek area of the Coeur d'Alene mining region in the fall of 1943. As a part of this project, exploring was done at theLittle Pittsburg property in 1945. The work included driving a 500-foot crosscut from the No, 6 level and drilling four diamond core drill holes to test the behavior of the Little Pittsburg vein at depth. This report presents the data obtained by the Bureau.ACKNOWLEDGMENTSIn its program of exploration of mineral deposits, the Bureau of Mines has as its primary objective the more effective utilization of our mineral resources, to the end that they make the greatest possible contribution to national security and economy. It is the policy of the Bureau to publish the facts developed by each exploratory project as soon as practicable after its conclusion. The Mining Branch, Lowell B. Moon, chief, conducts preliminary examinations, performs the actual exploratory work, and prepares the final report. The Metallurgical Branch, R. G. Knickerbocker, chief, analyses samples and performs beneficiation tests.The Bureau's exploration of the Little Pittsburg vein was one of the activities of the Albany Division of the Mining Branch, S. H. Lorain, chief. The project was started by R. M. Gammell, mining engineer, and was continued by the author and J. R. Reynolds, assistant mining engineer.The chemical analyses included in this report were made at Reno, Nov., under the direction of A.C, Rice, acting engineer in charge, Rare and Precious Metals Experiment Station, Bureau of Mines.The cooperation and assistance of the management of the Denver Development Co. is gratefully acknowledged, in particular that of C. E. Nugent, who made available much of the operational data included in this report."

Jan 1, 1947

By J. M. Keane

Critical to successful dump and heap leaching for copper is an adequate testing program for evaluation of the applicable parameters. This paper deals with testing methods to establish best conditions for dump and heap leaching of copper so that commercial operations can proceed on a rational basis. Discussion is also offered of ore occurrences suitable for dump and heap leaching.

Jan 1, 1985

By Brianna M. Eiter, Jennica L. Bellanca

Mineworkers face a challenging and dynamic work environment every workday. To maintain a safe workplace, mineworkers must be able to recognize worksite hazards while they perform their jobs. Though hazard recognition is a critical skill, recent research from the National Institute for Occupational Safety and Health (NIOSH) indicates that mineworkers fail to identify a significant number of hazards. To further the understanding of mineworkers’ hazard recognition ability and to begin to address hazard recognition performance, NIOSH researchers analyzed data collected during a laboratory research study to determine the effect of individual mineworker factors including risk attitude, work experience, and safety training on hazard recognition accuracy. The results of this study show that mineworker risk attitude and safety-specific work experience affect hazard recognition performance while hazard-specific safety training does not. These results suggest that some of these individual factors can be overcome through experience and training. Potential strategies that can be used to address these factors are also discussed.

Aug 31, 2020

By Larsson Lars-Erik, Rani Isa, Martin Jönsson, Håkan Bredenberg, Mats Larsson

"IntroductionSteel Core Piles are used extensively in Scandinavian countries, where hard rock is found within reasonable depths. A steel core is cast into a drilled steel tube casing and a rock hole is extended below the casing. This pile type is considered a very reliable type of pile, and for urban environment it has several advantages compared to other types of piles. One critical phase of the installation is the drilling of the casing. Usually a DTH (Down The Hole) hammer is used. Drilling in fine grained soils, e g silt, below the ground water level, may give rise to an excessive volume of soil material flushed up from the point of the casing, resulting in unacceptable settlements around the pile installation area.Using a new method for drilling of the casings, the ELEMEX-method has proven to significantly reduce the risk for such problems. In the paper a case record from a ground improvement project in central Stockholm is described. Ground settlements around the drilling area were carefully monitored over a longer period. Both the new drilling method and the conventional DTH casing drilling method where used, so that the corresponding ground settlements could be compared. Settlement records and comments are included in the paper.The paper also gives a description of the project. The installation of new piles and foundation constructions cover a whole city block in Stockholm downtown. The reason for the replacement of the old, damaged wooden piles were due to their destruction caused by a long time lowering of the ground water table. The paper gives a description of the new drilling method as well as an overview of usual urban foundation issues and their solution in Sweden, Finland and Norway.Drilled Foundation MethodDrilled Foundation, using drilling methods originally developed for drilling of large diameter rock holes, is today a standard method for the installation of piles, tiebacks, drilled pile walls and other foundation components, especially in urban built up areas where other techniques as drop hammers, augers, vibratory hammers and other equipment fail to meet the requirement, se ref(1). Drilled foundation is for example used for"

Jan 1, 2014

By Martin Grenon

This paper presents two case studies where fracture set orientation was quantified using three methods: a simple fracture pole grouping, a Fisher distribution and a Kent distribution. The three fracture orientation representations were then used as inputs for kinematic slope stability analysis. Differences showed up in the probability of sliding for all instability modes considered.

Aug 1, 2013

By W. E. Wallace, J. A. Warren, D. Josell, D. Wheeler

"We present the results of experiments and modeling of flip-chip geometry solder joint shapes under shear loading. Modeling, using Surface Evolver, included development of techniques that use an applied vector force (normal and shear loading) as input to determine a vector displacement of the pads connected by the solder joint (standoff height and misalignment). Previous solutions solved the converse problem: fixed displacements used to determine required applied force. Such solutions were inconvenient for applications, where the applied force (chip weight) is known. Also, for geometric and materials studies of solder joint shapes involving multiple parameters, determining the equilibrium displacement from applied force by bracketing solutions could become computationally expensive. Measurements of solder joint standoff height and misalignment as functions of the applied force (normal and shear), solder volume and pad diameter are presented. Experiments were carried out for solder ball diameters from 0.38 mm (0.029 mm3 volume) to 0.15 mm (0.0019 mm3 volume) on pads of diameter 0.64 mm and 0.35 mm. Fitting of simulation to experimental results gave optimized values for the contact angle and surface tension of the solder which were consistent with measured and literature values. IntroductionIn packaging technology flip-chip has become an important method for attaching semiconductor devices to substrates. Generally, the chip and substrate are bumped with solder and then the chip is flipped onto the substrate and the solder reflowed to form conductive interconnects. An epoxy underfill is normally flowed between the substrate and chip to reduce the thermal fatigue on the solder joints. A flip-chip assembly is illustrated in Figure 1.In flip-chip applications, the use of an integrated underfill/solder bump system [1, 2) removes an extra process step, namely infiltration of the underfill. However, the presence of an underfill will retard the self-alignment of the flip-chip. A first step in understanding and predicting this retardation is to develop a model to describe normal and lateral force-displacements curves when underfill material is not present. At this stage it is unclear whether static surface tension theory is sufficient to describe a complete model for flip-chip realignment even without underfill."

Jan 1, 2001

By Joseph J. Wallace

The 1952 Annual Report of the West Virginia Department of Mines lists seven beds that are being mined in Mingo County, of which the Cedar Grove is the most important. The Cedar Grove, Alma, and Coalburg contain the largest remaining known reserves. 2. Known measured and indicated reserves in all beds, based on a minimum thickness of 14 inches and 1,800 tons per acre-foot of coal in place, are estimated at 3,007 million short tons as of January 1, 1953. Of this total, 2,396 million short tons is in beds 28 inches and more thick. Areas in each bed were omitted from the estimate because available data relative to the bed characteristics are too meager for making an estimate that conforms with the definitions of measured and indicated coal adopted for this study. Should future drilling or development prove reserves in these areas, such reserves should be added to the total estimated reserves.

Jan 1, 1954

In classical drill and blast underground mining methods, especially narrow vein operations economic quantities of broken ore can be left behind following normal mucking operations on the stope floors. The ore left behind can have significant economic value and if not collected can be lost forever. This paper reviews techniques for cleaning this material from stopes that have been used in the past and reviews possible modern techniques that can be applied to ensure this valuable material is removed from the stopes.

Aug 1, 2010

By G. Vogt

Water is one of the most important ressources of our planet. Unlike many other natural resources, water cannot be substituted by anything and must therefore be handled with the utmost care. Depending on the region and the possible shortage of water, the importance of water increases even further. Water consumption is not the only factor. In the construction industry, water pollution from auxiliary and operating materials and processes as well as other contaminants and their resulting load on wastewater play an important role. The sources for wastewater on tunneling construction sites are various: Washing water, seepage water accumulating in construction pits, tunnel water, water used in the slurry circuit in fluid-assisted tunneling methods or water from concrete work and stone cutting all these waters are contaminated with a range of pollutants like solids, hydrocarbons, heavy metals, etc. These contaminants can be removed or treated/reduced with the help of specifically designed wastewater treatment plants (WTPs). After the treatment the cleaned water can be either, in best case, reused on the construction site itself or discharged into water utilities like the available sewer or river pin respecting their discharge requirements. Due to dwindling water resources globally, the continuously rising discharge limits and the ever more important aspect of sustainability the use of WTPs on tunneling construction site will be indispensable. In this paper, it will be presented how these systems are designed and work, what advantages they offer environmentally as well as financially and what to look out for when planning and implementing such a system onto jobsite.

Jun 23, 2024

By W. E. Wallace, B. L. Razzaboni, P. Bolsaitis, M. J. Keane

"Therma1 and chemical treatment of respirable size silica dusts samples is shown to induce marked changes in their hemolytic activity. The cytotoxicity of crystalline a-quartz (Min-U-Sil), and fumed silica (Cab-0- Sil) particles, as measured by a hemolytic activity protocol, is decreased by calcination and can be related to the dehydroxylation of the surface. The hemolytic activity of P-cristobalite particles of respirable dust si7.e was also determined and found to be lower than that of a-quartz. The change in the surface structure resulting from thermal treatment is detectable by photo-acoustic infrared spectroscopy and zeta-potential measurements. The absorption band in the 3200-4000 cm-1 frequency region of both Cab-0-Sil and MinU- Sil disappears upon heat treatment while a sharp band, identified with single silanol groups, at 3750 cm-1 increases in intensity. The zeta potential-pH profile, in the pH range of 4.0-7 .0, of the calcined, siloxane surfaced particles is more negative than that of material with a silanol surface.The cytotoxicity of the crystalline and fumed silica dusts was also found to be strongly dependent on particle size. Fumed silica of large surface area (small particle size) exhibits an initial increase in hemolytic activity upon calcination. This result confirms other experimental observations pointing to a particle size of maximum toxicity. INTRODOCTIONThe toxicity of silica and other mineral particles, as manifested by their role in inducing pneumoconiosis, fibrosis, silicosis and other pulmonary disorders is largely traceable to the characteristics of particle surfaces and to particle morphology. The great wealth of data on the physical and chemical properties of silica is still insufficient for a comprehensive understanding of the specific parameters to be associated with fibrogenic activity and, correspondingly, with the optimum means for characterizing and quantifying the toxicity of dusts, and the design of possible preventive or therapeutic methods.The great diversity of parameters that have been proposed and tested for correlation with cytotoxicity suggest that more than one mechanism may be involved in the fibrotic activity of silica particles. The crystalline structure of the material (more active tridymite versus less active crisobalite and passive stishovite), freshly formed surfaces and free radicals associated therewith, silicic acid adsorbed onto silica surfaces, the concentration of hydroxyl groups at silica surfaces, particle size and morphology, among other properties, have been investigated and found to conelate in tests of cytotoxicity."

Jan 1, 1990

By AIME AIME

THE 130th Meeting of the Institute was held in Birmingham on Oct. 13 to 15, with visits to other mines and districts before and after. The last visit of the Institute to Birmingham was made in 1888, thirty-six years ago, and vast development has been made in' the district since then. With proverbial southern hospitality compounding over this period of years the welcome given to the Institute was such that .it is difficult to express properly the gratification and appreciation of the visiting members and the officers of the Institute. The Birmingham News in an editorial said: Birmingham is duly appreciative of the presence of these gentlemen, not because they are all distinguished in their great services in the mining and metallurgical world, but for the further reason that our interests are very largely wrapped up in their deliberations. Birmingham is one of the great industrial centers of America. Their discussions are of vital concern to all of us.

Jan 1, 1924

By G. B. Harris, C. W. White

Cyanide has been used for the recovery of gold since the mid 1800s, but several jurisdictions have already banned its use, and environmental pressures are increasing to finding an alternative. Gold also forms chloride complexes similar to those of cyanide, but the use of chloride has never achieved widespread acceptance. This paper describes a chloride-based flowsheet, wherein the key unit process is the recovery and recycle of chloride ion. It is shown that the chloride-based flowsheet is competitive economically with the conventional cyanide-based flowsheets, and that it has a number of other advantages, particularly environmentally.

Jan 1, 2011

By C. C. Popoff

The development of glass-making industries in the Pacific Northwest as well as other industries that use pure silica has been retarded by lack of local supplies of low-cost raw material. Several quartz deposits along the Skagit River constitute the only known source of relatively pure silica within the range of cheap transportation to the Seattle industrial area. Although some silica has been mined from these deposits, very little information regarding their size, grade, and other physical characteristics has been available to the general public. As a part of its program of investigation of the mineral resources of the Pacific Northwest, the Bureau of Mines assigned the writer to examine the Skagit River silica deposits in October 1946. This report presents the factual data obtained from an examination of the so-called Stoner, Bacon Creek, and Pressentin deposits. These deposits are the largest and most easily accessible known to exist in the area. The deposits are near Marblemount, which is on State Highway 17A. They are within 1 mile to 1-1/2 miles of the Skagit. River Railway, which provides transportation to Seattle, a distance of 130 miles. None of the deposits has been developed thoroughly. The Stoner deposit, however, has been developed by a quarry about, 5,0 feet square and has been exposed by hydraulic removal of the overburden throughout a distance of 180 feet along the hanging wall of the vein

Jan 1, 1949

By Lee R. Kump, Sarma V. Pisupati, Peter L. Rozelle, Alan R. Larson, Timothy S. White, Nicholas A. Crescenzo, Maureen D. Feineman

The Mercer Clay bed in central Pennsylvania has produced feedstocks for the refractory industry in the USA and has also been investigated as a source of alumina and lithium. Developments in global markets for these commodities, as well as rare earth elements, have led to their classification as critical minerals in the USA, in turn renewing production opportunities for the Mercer Clay resource. The work reported here includes a review of the clay types and minerals involved, as well as past mineral processing and extractive metallurgy test work, and reports new research results from renewed investigation of the deposit as a polymetallic resource. This renewed work has found lithium contents that exceed 1,000 ppm, lying directly below the overlying Mercer coal, where the alumina content ranged from 32 to 34 wt%. Total rare earth concentrations were somewhat lower than have been found elsewhere in the region, and the highest contents were also found to be stratigraphically close to the coal. Further work is required to establish the mineral hosts for lithium and rare earths and to define the extent of enriched alumina, lithium, and rare earth concentrations.

Jul 22, 2021