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By Richard H. Olson

Talc is currently mined in the U.S. in six major districts. The size and depth of the ore bodies and their mineralogy dictate the types of products manufactured and the mining and processing methods which must be employed. The geology of the major deposits is well known and will be but briefly discussed The major emphasis will be placed upon the past history of the districts, the size and depth and configurations of the ore bodies, the ore mineralogy, and how all of these factors govern the types of mining and processing operations which may be employed in each of the districts.

Jan 1, 1984

Hard rock TBMs are very often open machine layouts, with just a part roof shield over the front of the machine. The whole system is designed for fast face advance and the economy of the project often depends entirely on the rate of advance. Typically, hard rock conditions will demonstrate stable and good ground for a major part of the tunnel. However, short sections of crushed shear zones with clay and gouge material may cause serious time delays. Spiling rock bolting has been proven to be very efficient under such circumstances, provided the fully grouted rebar bolts can be placed in a controlled and practical manner.Environmental restrictions are becoming more and more a part of tunnel excavation projects. Even hard rock TBM tunnelling may require a strict ground water control, because of consequences on the ground surface from lowering the ground water level. Such consequences may be surface settlement, negative influence on ground water resources or damage to vegetation.Pressure injection ahead of the advancing tunnel face (in this paper named pre-injection), using microfine cement and chemical grouts, is today a proven technology. As examples can be mentioned (Garshol, 1997) about 100 km of pre-injected tunnels below Oslo City and about the same length of subsea tunnelling elsewhere in Norway. Examples from other parts of the world are also available, like below Stockholm, Sweden, the Inland Feeder project and Hollywood Metro both in Southern California.To take advantage of spiling rockbolts and pre-injection, it is an obvious prerequisite to be able to drill the necessary boreholes in the right positions and at the correct angle. In drill and blast excavation this is simple, but in TBM projects it has repeatedly turned out to be difficult. More than once owners have accepted bids containing reassurance from the contractor that the drilling method will be sorted out later. Experience shows that if ælaterÆ means after start of the TBM operation, it is often too late.

Jan 1, 1999

The modern resource extraction enterprise is a complex capital intensive business operating in a world of constantly evolving social, environmental and economic scrutiny. Investors, government, media and special interest groups expect to see business environmental and social performance respond and deliver increasing corporate responsibility and sustainability.   Thorough interrogation of business performance using a multi-disciplinary due diligence approach presents a more sophisticated review and benefits beyond the traditional compliance/conformance 'audit' style assessment.   Using a due diligence approach allows assessment through a comprehensive lens which examines potential short- and long-term risks including sometimes less tangible environmental and social liabilities, and informs management, investors and regulators of broader business performance. This approach provides information in a form that business can measure performance in a repeatable and enterprise wide sense.   This paper provides an outline of the due diligence process applied in this way, drawing from lessons learnt and industry based experiences in the due diligence process and the benefits and tools that can  be applied in an environmental and social due diligence business performance assessment

Jun 1, 2010

By Saverio Agresti, Giuseppe Lunardi, Donato Basta, Roberto Trapasso

"At a distance of 10 years from the first application of the Nazzano Method, the widening under traffic of a tube of an existing motorway tunnel was realized near Ancona, along the A14 Motorway in Italy. This paper describes the works for the enlargement with conventional method of the second tube, very close to that already widened under traffic.This enlargement was realized very fast, taking into account the advantages of some interesting technological improvements of the Final Design proved in the first tube.INTRODUCTION TO THE WIDENING OF EXISTING MOTORWAY TUNNELSThe widening of a twin-bore motorway tunnel usually considers the double option of creating a third bore as an alternative or closure to traffic of one of the two bores with the resulting reduction in the level of service for users.On the contrary, the extension in situ of a road, motorway, railway or underground tunnel in the presence of traffic, made possible by an inspired idea of Prof. Pietro Lunardi, enables the level of service of the infrastructure to be maintained without the need to resort to alternative routes to create new permanent or temporary bores, not always feasible because of the lack of the necessary space.This construction technique, known as the ‘Nazzano Method’, is part of the technologies refined and offered by the ADECO-RS approach to tunnel design and construction (Lunardi P., 2008) which is increasingly used in the world, leading to the industrialisation of tunnelling (meaning respect for the times and costs set out during detailed design) both in conventional and mechanised (through TBM) excavations.The first true experimentation of the ‘Nazzano Method’ was carried out between 2004 and 2007 to enlarge the two-bore ‘Nazzano’ tunnel (Italy, Milan-Rome A1 motorway) in the presence of traffic, widening it to house from two to four lanes in each direction (Lunardi P. et al., 2007). Following the success achieved in this first application, the Nazzano Method was strengthened considering all the possible suggestions arising from the previous experience and then taken up to enlarge the north bore of the ‘Montedomini’ two-bore tunnel (Italy, Bologna-Taranto A14 motorway), in situ and the presence of traffic."

Jan 1, 2016

By R C. A Minnitt

The two methods for calibrating the parameters K and (alpha) for use in Gy’s equation for the fundamental sampling error (FSE), the duplicate sampling analysis (DSA) and the segregation fractionalised analysis (SFA) are described in detail. A case study using identical broken reef material from a Witwatersrand-type orebody is calibrated using the DSA and SFA methods and the results are compared. Classically, the form of Gy’s equation for the FSE raises the nominal size of fragments given by dN to a power of 3. Gy’s formula is a theoretical formula applicable in the case when fragments are randomly collected one by one, which is obviously never the case. This is because the fragment shape factor (f) and the granulometric factor (g) were introduced to take care of this anomaly. More recent formulae, such as those suggested by François-Bongarçon and Lyman, are empirically based formula. A later modification of Gy’s formula raises dN to the power ? (alpha), the latter term being calibrated with the coefficient K in the DSA and SFA methods. The preferred value of ? (alpha) for low-grade gold ores used by sampling practitioners in the mining industry is 1.5. A review of calibration experiments for low-grade gold ores using the DSA and SFA methods has produced values of K that vary between 70 and 170 and values of alpha in the range 0.97 to 1.30. The average value for alpha is found to be 1, rather than 3 as originally proposed in the classic form of Gy’s equation or the industry preference for 1.5. It is suggested that for low-grade gold bearing ores, the equation for the FSE should raise dN to a power of 1. Such an equation for the variance of the combined FSE plus the grouping and segregation error, now referred to as the short-term component of the quality fluctuation error (QFE1), greatly simplifies the characterisation of gold ores, which now only requires the calibration of K for a given mass and established fragment size. The implications for the heterogeneity test from the generalised equation are that provided the fragments have been screened to within a narrow size range, any particular size will return a value for K that is acceptable for use in the sampling nomogram.CITATION:Minnitt, R C A, 2017. A generalised form of Gy’s equation for gold ores – empirical evidence, in Proceedings Eighth World Conference on Sampling and Blending , pp 331–350 (The Australasian Institute of Mining and Metallurgy: Melbourne).

May 9, 2017

Minerals processing operations use a significant quantity of fossil carbon to provide energy and as reductant. Greenhouse gas emissions from the use of this fossil carbon contribute to the global increase in anthropogenic CO2 emissions to the atmosphere. In the spirit of fostering thinking about a step change in this situation, this paper explores opportunities for the use of sustainable carbon from biomass sources in a range of mineral processing operations. The exploration shows that many common processes are contenders for fossil carbon replacement and that feasible scientific research by minerals processing technologists would add to deeper understanding of the potential for a sustainable bio-carbon based industry. It is also shown that there are many dilemmas on the social, environmental and economic fronts to be solved before a biomass based industry could become a reality.

Jan 1, 2004

By V. F. Parry, W. S. Landers, John B. Goodman

"INTRODUCTION The object of this investigation was to demonstrate a satisfactory method of storing slack subbituminous coal in open pits in a manner,that would minimize the cause of the physical deterioration and would have a practical application.The storage of coal by industrial plants is to their advantage, since an adequate operating supplying of fuel is available at all times as insurance against transportation delays, shortages, and strikes. Furthermore, it is possible to participate in low seasonal freight rates and mine costs by permitting the railroads to utilize idle equipment and by taking advantage of the off-peak production at the mines. For a number of years, one of the larger beet-sugar companies operating in the Rocky Mountain region has taken advantage of the lower prices and seasonal production of subbituminous slack coal during the summer months and purchased a large proportion of its requirements for the annual winter campaign. This company, operating sugar-refining plants in the 1943 campaign, used 256,613 tons of subbituminous coal. Of this quantity, 166,636 tons was purchased during the off-peak season and stored for use during the winter. It is the practice of this concern to place coal purchased through the months of January to October in underwater storage for use in the beet-sugar campaign, which lasts from October to as late as, January. The beet-sugar refining ""campaign"" period starts immediately after the beginning of the beet harvest and lasts 60 to 70 days."

Aug 1, 1946

By J. S. Hansen

The U.S. Bureau of Mines developed a system for casting unique, slotted steel armor by modifying the conventional expendable pattern casting (EPC) process that is normally used for making aluminum castings. Three innovations were added to the EPC process to make the successful adaptation: (1) Vacuum was applied to sand molds, (2) continuous narrow-necked feeding systems were used to permit the casting of thin walls, and (3) fixtures were designed to prevent pattern damage and to hold critical casting tolerances, Potential problems and defects are described.

Jan 1, 2010

By Waddah Akili

At an offshore site along the Red Sea coast of Saudi Arabia, marine structures were supported on tubular steel piles driven into coral and coral contaminated sands and silts. Surprises and disappointments faced during the installation of the piled foundation were, to a large measure, due to inappropriate design methodology and absence of proper soil information. The paper describes the design evolution process, highlights the static pile test program conducted to verify design parameters, and amplifies the need to prepare for worst possible scenario when coral deposits are encountered. Despite corrections made to the design, based on site-specific insitu parameters (skin friction, end bearing) perceived from load tests conducted on site; the final design adopted overestimated capacities in over 50 percent of total piles driven. The paper describes the changes introduced to the design during the execution of the project, highlights the pile test program conducted to verify the design, and compares pile design penetration with actual penetration depth. The unpredictable and erratic pile behavior observed, ascertains the need for more appropriate pile design and installation guidelines for driven piles in coral and coral contaminated formations.

By J. P. Sairrlon, K. G. Wheeland, K. J. Mintz, B. J. Kiener

Iwenty-one ore dusts of varying mineralogy, sulphur content and reputed in-mine explosibility were selected from eight mines. After chemical and mineralogical analysis and sieving into two size fractions (+45/ -63 microns and -45 microns), these sarrples and seven pure minerals were tested for explosibility in oxygen in a Harbnann chamber. '!he maximum explosion pressures and maximum rates of pressure do not correlate with sulphur content alone; the types of minerals are also .important. Residues were analyzed to check the combustion reactions. Further comparisons between laboratory and mine results are planned to improve predictability.

May 11, 1988

By Michelia Alba, Ronaldo S. Sampaio, Davi S. Braga, Mathieu Dubé

Climate change is pressuring industries and governments for decarbonization commitments, research, testing, and use of best practices to achieve the target of global warming below 1.5/2 °C. As it accounts for as much as 7% of all global CO2 emissions and 7% of energy consumption, the steel sector needs to address this issue with extended efforts. This paper provides information on the key potential of renewable biochar as an alternative fuel for pellet production. It also summarizes the successful application of biochar in a pioneering case study as the main fuel for a Grate-kiln pellet plant in Brazil, as well as the study of its use to replace coke and anthracite as an additive for iron ore pellets and other possible applications in the steel industry in COREM's precompetitive research & innovation program. The final discussion reveals the large quantity of biochar required by the Brazilian and Quebec scenarios for reducing CO2 emissions of iron ore pelletizing plants.

Jan 1, 2023

By S Smith

Several styles of copper (Cu) mineralisation are present at Sepon. Large tonnage, low grade skarn and carbonate replacement massive sulfide mineralisation occur within the metamorphic aureole of Permian-aged rhyodacite porphyry intrusions (RDPs). During exhumation and supergene weathering, this primary mineralisation has been upgraded to form high-grade chalcocite enriched zones up to 50 m thick, which comprises the bulk of Cu resources currently being mined at Sepon. Groundwaters remobilise Cu to form exotic accumulations of malachite that are locally hosted in irregular karsts in carbonate rocks, found up to 1000 m from source mineralisation. Khanong is the largest Cu deposit and recent discoveries have been made at Thengkham South, Thengkham North and Phabing. All deposits have formed by similar processes of mineralisation. However, all differ due to local variations in host rock lithology, structural setting, and hydrological conditions. An EXTENDED ABSTRACT is available for download. A full-length paper was not prepared for this presentation.

Jan 1, 2008

By Daniel R. Shawe

Ore deposits of the western U.S. are divisible broadly into two genetic groups, a smaller one that fits the plate tectonic model of subduction and a larger one that appears unrelated to subduction. Some of the middle Paleozoic and lower-middle Mesozoic ore deposits in the western U.S. are associated with eugeosynclinal rocks and lie a few hundred kilometers west of reconstructed continent margins. These deposits probably formed as a result of subduction beneath oceanic or thin continental crust that was analogous to subduction predicated for the Kuroko massive sulfide deposits of Japan. Some middle Mesozoic porphyry copper deposits may have formed east of the continental margin when subduction-generated magmas were emplaced high in continental crust in a manner analogous to subduction-generated magmas that formed the Andean porphyry copper deposits. Most Cretaceous-Cenozoic ore deposits lie in a broad region extending many hundreds of kilometers east of the continent margin and characterized by conjugate tectonic zones, high terrestial heat flow, and low seismic velocity in the upper mantle. The deposits likely were formed in relation to magmas generated along the conjugate tectonic zones during differential northwestward drift and internal wrenching of the continental plate.

Jan 1, 1978

By C. A. Heiland

IN the third year of war, geophysical oil exploration broke all records to keep pace with the demand for increased reserves. Geophysical prospecting for strategic and other minerals also grew in scope. The trend of geophysical oil exploration throughout the war is indicated in Fig. 1. This figure resembles the one presented in the last annual review issue of M&M (February 1944, p. 62), corrected for data on-operations in the last months of 1943 and extended into 1944. The average number of geophysical oil prospecting crews in the field in 1944 was 451, whereas the total in 1943 was 340. An upward trend in the use of all geophysical methods is clearly evident throughout the year. Seismic operations were 67 per cent, gravimeter surveys 28 per cent, and other methods 5 per cent of the total. Seismic reflection and refraction crews increased 181/2 per cent over the 1943 average, gravimeter operations increased 73 per cent, and other methods gained 92 per cent. The increase in seismic and gravimeter operations, particularly the latter, is probably due to an increased production of equipment and the organization of new service companies. Miscellaneous methods gained largely through a revival of magnetometer work, and an increase in the use of torsion balances and electrical equipment. In comparison with the prewar average of 1941, it is noteworthy that seismic operations increased 58 per cent, gravimeter operations 88 per cent, and miscellaneous other methods gained as much as 283 per cent. Unfortunately the expansion in the number of geophysical crews does not indicate a proportionate increase in efficiency or in areal coverage, as will be brought out later.

Jan 1, 1945

By Donald A. Bruce

"Abstract The Deep Mixing Methods (DMM), in their current forms, have been employed in the United States since 1986, although an earlier version had seen service from 1954. The earlier developments were strongly influenced by practices in the Nordic countries and Japan, while by the late 1980’s several DMM systems had been developed in the U.S. itself. Since then, DMM has continued its evolution, principally via the challenges of a series of large, landmark projects, but also via distinct, significant technological advances. This paper highlights the key points in the history of DMM in the U.S., and provides an overview of the different methods currently in use.In the BeginningIt is a common misconception that the history of applications of the Deep Mixing Methods (DMM) in the United States dates from 1986 when SMW Seiko Inc. — a subsidiary of Japan’s Seiko Kogyo Company — was established in the Bay Area. However, the author believes that Intrusion Prepakt Co.’s patented MIP (Mixed in Place) system had been used, albeit sporadically (about 30 projects are recorded), since 1954 (FHWA 2000, 2001). Ironically, by 1961 this single auger method had been extensively used under license in Japan for excavation support and groundwater control — by the Seiko Kogyo Company. By 1972, the original MIP technique had been succeeded by more advanced Japanese methods, involving multiple augers. Intrusion Prepakt have long since become defunct.The first systematic studies of contemporary Deep Mixing Methods in Japan began in 1967 when the Port and Harbor Research Institute of the Ministry of Transportation began laboratory testing using granular and powdered lime for treating soft marine soils. Fundamental studies continued through the early 1970’s, by which time the development of industrial scale equipment was well advanced, having its first application on a marine trial near Haneda Airport. Coincidentally, laboratory and field research also began in 1967 in Sweden (“Swedish Lime Column Method”) for treating soft clays using unslaked lime. Reportedly the progenitor was a Norwegian, Kjeld Paus, who had made observations on fluid lime columns in the U.S. It would seem that developments in Japan and the Nordic countries proceeded independently until 1975 when the technology leaders from each group (Broms and Boman; and Okumura and Terashi, respectively) presented their — very similar — findings at a conference in Bangalore, India. Limited technical exchanges ensued thereafter.Whereas the Nordic developments continued to focus on the use of dry reagents (cement and lime) and relatively light equipment compatible with operating on and in very soft clays and organics, the Japanese progressed into the use of fluid reagents (cement-based grouts) and heavier equipment for both marine and land-based projects. Thus, by 1986, there were a large number of proprietary (wet and dry) DMM systems in Japan, and a rapidly growing market already by then accounting for over 12,000,000 m3 of ground treatment."

Jan 1, 2014

By A. V. Tarasov, V. M. Paretsky

"The design is based on the thermal processing of the wastes in· the intensively bubbled melt in the Vanyukov furnace at the relatively high temperatures (1350- 1450 °C), In this case: -the secondary wastes are not formed; - the especially toxic substances at the outlet from the furnace are absent. The technology was tested on a large scale (on semicommersial bases). Technical and economical basis show profitability of recovery complex for processing of hard garbage waste (HGW) using this technology: the period of capital, investments refunding for the, recovery, complex construction with process annual capacity of 240 thousands tons of wastes is 1,5-2,5 years,"

Jan 1, 2000

By J. T. McCartney

The Bureau of Mines has developed an automated reflectance scanning microscope system, primarily for determination of volume proportions, size distribution, and mode of association of the physical (petrographic) components of coals. The process, which is potentially more rapid and objective and less tedious than a visual microscopic procedure, involves magnetic tape recording of several millions of reflectance readings on micro-meter sized areas of polished coal surface and computer analysis and interpretation of some characteristics of the coal components. The system was tested in a study of pyrite distribution in steam coals. The application was essentially successful, but defects in polished pyrite surface characteristics and problems in adequate sampling prevented completely satisfactory results. Pyrite con-tent and coal-pyrite particle association could be determined nearly as well as by visual microscopy, but size distribution data were less acceptable.

Jan 1, 1969

By Tony Amis, Marco Barla, Alice Di Donna

"Energy geostructures are becoming an increasingly popular solution around the world for Developers looking to reduce CO2 and system running costs. Energy geostructures are geotechnical structures that provide both the important role of structural stability while also acting as a heat exchanger with the ground, enabling the supported buildings and or infrastructure to be heated and cooled using the principle of low enthalpy geothermal systems. The main advantage of this innovative technology with respect to standard geothermal plant is the reduction of the initial installation costs and construction schedule benefits, compared to installing conventional geothermal solutions, largely due to the additional use of structures which would be constructed in any case. However, it is important with respect to energy geostructures that additional aspects need careful consideration. For this very reason, several research studies have been carried out over the last decade on this subject and a number of real case studies have been monitored and analysed. The key difference with respect to conventional shallow geothermal systems are mainly related to the geometry, which is imposed by the geotechnical project, and the need to ensure that the primary structural role is always guaranteed. Special boundary conditions, the reduced depth, the influence of atmospheric external temperature can also play an important role for energy geostructures. They can affect, both energy efficiency and, the geotechnical behaviour because of the possible thermal induced mechanical effects. This paper presents a picture of the current situation regarding energy geostructures and their peculiar features, and collects available data to provide a reference framework. Data has been collected from literature and personal communications and then processed to provide easy-to-read charts useful for practical consultation at a glance. This paper provides, an indication of the distribution of such systems worldwide, their spread in time, and a global view of their actual efficiency from the structural, energy, economic and environmental point of view.1. IntroductionEnergy geostructures are becoming an increasingly popular consideration around the world. Energy geostructures are geotechnical structures with a dual role of providing structural stability and the ability to exchange heat with the ground, to provide low carbon heat and coolth to supporting and or adjacent buildings and infrastructure, using the principle of low enthalpy geothermal systems (Barla and Di Donna, 2016; Laloui and Di Donna, 2013). A closed circuit of high density polyethylene (HDPE) pipes is embedded in the concrete, and a heat carrier fluid circulates through them exchanging heat with the ground. The HDPE pipework circuit inside the geostructure is linked to one of the above buildings or infrastructure through a heat pump, which adapts the temperature of the circulating fluid to the heating (winter mode) and cooling (summer mode) needs. In this way, heat can be injected into the ground during summer and extracted from it during winter. In principle, all structures in contact with the ground can be used as energy geostructures. The first examples of energy geostructures date back to the eighties in Austria and were mainly piles and shallow foundations. A decade later, Henderson et al. (1999) reported on what would appear to be the first successful use of geothermal energy piles in the US, with loops incorporated into the foundation for a hotel in Geneva, New York. As was their use in this New York case history, the typical geothermal energy pile application is used in conjunction with additional closed loop boreholes to provide the required energy capacity for a structure. Interestingly the report concludes that the geothermal energy piles had a better heat transfer performance than the borehole field. The first energy walls appeared slightly later, while still today only a few experimental cas"

Jan 1, 2017

By D. An, J. Withers

A nano-scale investigation has been carried out by applying an AFM (atomic force microscope) to study in situ the adsorption of various collectors, i.e., oleic acid, octanohydroxamic acid (HA), and salicylhydroxamic acid (SHA), on bastnaesite in aqueous solutions. The obtained AFM images show that the surface morphology of bastnaesite changes greatly after it contacts the solutions of the collectors, suggesting that all these collectors can effectively adsorb on bastnaesite. Increasing temperature can help increase the adsorption of oleic acid on bastnaesite. FTIR (Fourier transform infrared) results also show that all these collectors adsorb strongly on bastnaesite with a strong absorbance spectra being detected, which confirms with the results obtained with AFM imaging analysis. In general, hydroxamic acid collector (HA and SHA) adsorbs on bastnaesite mainly in the form of insoluble metal hydroxamate. This specific adsorption mechanism explains that a high selectivity with a moderate collectivity will be achieved with a hydroxamic acid collector for the flotation of bastnaesite. INTRODUCTION Rare earth metals, which are very important to modern industry, are generally extracted from numerous rare earth minerals. In practice, however, the actual extraction of rare earth is mainly from bastnaesite, monazite and xenotime. The Mountain Pass mine is one of the largest rare earth mine in the world, at which the main rare earth mineral is bastnaesite. In the past years, froth flotation has been applied to the beneficiation of Mountain Pass ore. In practice, the rare earth ore is usually crushed, milled and further separated from calcite, barite and other gangue minerals by froth flotation, in which the rare earth oxide-bearing minerals stick to aerated bubbles in the pulp and float to the surface, leaving the gangue at the bottom of the flotation cell and disposed of as tailings.(Bulatovic, 2010) In spite of the fact that froth flotation has been applied to treat the bastnaesite ore at the Mountain Pass mine, the rare earth oxide (REO) recovery is still low,(Anderson, 2015) especially compared to the one obtained with sulfide flotation. For example, the typical recovery obtained at the Mountain Pass mine was only about 70%. This may be due to the low selectivity of the collector (oleic acid). In addition, to enhance the flotation selectivity, the pulp in the mine circuit has to be heated up to 70 to 90°C and it involves a lot of energy consumption. Last but not the least, a lot of depressants have to be added to improve the selectivity of flotation process. Therefore, it is critical to re-examine the existing flotation process at the Mountain Pass mine and seek any chance of improvement. (Anderson, 2015)

Jan 1, 2019

By William E. Wallace, S. J. Page, B. L. Razzaboni, C. A. Hill, Pamela Mike, P. Bolsaitis, M. J. Keane, Val Vallyathan

"Respirable quartz cytotoxicity, as measured by erythrocyte hemolysis and pulmonary macrophage release of lactate dehydrogenase in vitro, is neutralized by boiling in water in glass test tubes for 10 to 40 minutes. The cytotoxicity is reduced to near zero by boiling l to IO mg quartz per milliliter water. For greater concentrations of quartz in water the hemolytic potential after 40 minutes of boiling approaches that of native quartz. Replacing the medium with fresh water midway through boiling results in full detoxification through 20 mg quartz per milliliter water. Pre-boiling the medium with silica reduces the detoxification effect. Detoxification persists after mild drying at l 10°C for 8 hours, and persists after three days of resuspension in water at room temperature.INTRODCJCTIONResearch underway to determine interactions of quartz and other mineral dust surfaces with pulmonary fluids and alveolar macrophages in culture led to the observation that when dusts were autoclaved in aqueous suspension, their cytotoxic effects on macrophages were suppressed, in some cases fully and even after several days incubation with the cells. This finding was in direct contradiction to earlier results from both short term macrophage lysosmal enzyme release assays, as well as longer term cytotoxicity assays from macrophages in culture; in those studies, dusts were steam autoclaved at 121°C with no liquid water but with steam present. 1.2 However detoxification under boiling conditions has been reported in other research. 3 It was decided to use the hemolysis assay to further investigate these findings, because of its sensitivity simplicity and cost.RESCULTS AND DISCCISSIONRespirable quartz dust used in this study was taken from a stock of crystalline silica, Min-U-Sil; obtained from Pennsylvania Sand Glass Corporation, fractionated in air with a particle classifier. The small size fraction retained for use was 80% less than S micrometer particle diameter, with an area equivalent median diameter of 1.24 micrometers as estimated by automated image analysis. The silica was at least 98.S mass percent silica as determined by X-ray energy spectrometric analysis; and the crystalline form was alpha-quartz as determined by X-ray diffraction. It's specific surface area was 3.97 square meters per gram as determined by nitrogen adsorption isotherm methods. I"

Jan 1, 1990